Literature DB >> 12356741

Differential accessibility at the kappa chain locus plays a role in allelic exclusion.

Maya Goldmit1, Mark Schlissel, Howard Cedar, Yehudit Bergman.   

Abstract

Gene rearrangement in the immune system is always preceded by DNA demethylation and increased chromatin accessibility. Using a model system in which rearrangement of the endogenous immunoglobulin kappa locus is prevented, we demonstrate that these epigenetic and chromatin changes actually occur on one allele with a higher probability than the other. It may be this process that, together with feedback inhibition, serves as the basis for allelic exclusion.

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Year:  2002        PMID： 12356741      PMCID： PMC129040          DOI： 10.1093/emboj/cdf518

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  47 in total

Review 1.  Clonal selection and learning in the antibody system.

Authors:  K Rajewsky
Journal:  Nature       Date:  1996-06-27       Impact factor: 49.962

Review 2.  Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements.

Authors:  B P Sleckman; J R Gorman; F W Alt
Journal:  Annu Rev Immunol       Date:  1996       Impact factor: 28.527

Review 3.  Accessibility and the developmental regulation of V(D)J recombination.

Authors:  M S Schlissel; P Stanhope-Baker
Journal:  Semin Immunol       Date:  1997-06       Impact factor: 11.130

Review 4.  A new view of V(D)J recombination.

Authors:  M Gellert
Journal:  Genes Cells       Date:  1996-03       Impact factor: 1.891

5.  Initiation of V(D)J recombination in a cell-free system.

Authors:  D C van Gent; J F McBlane; D A Ramsden; M J Sadofsky; J E Hesse; M Gellert
Journal:  Cell       Date:  1995-06-16       Impact factor: 41.582

6.  Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region.

Authors:  A G Betz; C Milstein; A González-Fernández; R Pannell; T Larson; M S Neuberger
Journal:  Cell       Date:  1994-04-22       Impact factor: 41.582

7.  Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice.

Authors:  E Spanopoulou; C A Roman; L M Corcoran; M S Schlissel; D P Silver; D Nemazee; M C Nussenzweig; S A Shinton; R R Hardy; D Baltimore
Journal:  Genes Dev       Date:  1994-05-01       Impact factor: 11.361

8.  Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro.

Authors:  P Stanhope-Baker; K M Hudson; A L Shaffer; A Constantinescu; M S Schlissel
Journal:  Cell       Date:  1996-06-14       Impact factor: 41.582

9.  The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein.

Authors:  H Ge; R G Roeder
Journal:  J Biol Chem       Date:  1994-06-24       Impact factor: 5.157

10.  Light chain replacement: a new model for antibody gene rearrangement.

Authors:  E L Prak; M Weigert
Journal:  J Exp Med       Date:  1995-08-01       Impact factor: 14.307
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  11 in total

Review 1.  Allelic exclusion of immunoglobulin genes: models and mechanisms.

Authors:  Christian Vettermann; Mark S Schlissel
Journal:  Immunol Rev       Date:  2010-09       Impact factor: 12.988

2.  Immunoglobulin kappa enhancers are differentially regulated at the level of chromatin structure.

Authors:  Barbara S Nikolajczyk; Sylvia H Sardi; Joseph R Tumang; Lisa M Ganley-Leal
Journal:  Mol Immunol       Date:  2007-03-26       Impact factor: 4.407

3.  Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion.

Authors:  Jingquan Jia; Motonari Kondo; Yuan Zhuang
Journal:  EMBO J       Date:  2007-04-05       Impact factor: 11.598

4.  Biallelic, ubiquitous transcription from the distal germline Ig{kappa} locus promoter during B cell development.

Authors:  Rupesh H Amin; Dragana Cado; Hector Nolla; Dan Huang; Susan A Shinton; Yan Zhou; Richard R Hardy; Mark S Schlissel
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-30       Impact factor: 11.205

Review 5.  Epigenetics of haematopoietic cell development.

Authors:  Howard Cedar; Yehudit Bergman
Journal:  Nat Rev Immunol       Date:  2011-06-10       Impact factor: 53.106

6.  Light chain inclusion permits terminal B cell differentiation and does not necessarily result in autoreactivity.

Authors:  C Sirac; C Carrion; S Duchez; I Comte; M Cogné
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-08       Impact factor: 11.205

Review 7.  Epigenetic control of recombination in the immune system.

Authors:  Yehudit Bergman; Howard Cedar
Journal:  Semin Immunol       Date:  2010-09-15       Impact factor: 11.130

8.  Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci.

Authors:  Matthew A Inlay; Tongxiang Lin; Heather H Gao; Yang Xu
Journal:  J Exp Med       Date:  2006-06-19       Impact factor: 14.307

9.  A novel pax5-binding regulatory element in the igκ locus.

Authors:  Rena Levin-Klein; Andrei Kirillov; Chaggai Rosenbluh; Howard Cedar; Yehudit Bergman
Journal:  Front Immunol       Date:  2014-05-23       Impact factor: 7.561

Review 10.  Epigenetic regulation of monoallelic rearrangement (allelic exclusion) of antigen receptor genes.

Authors:  Rena Levin-Klein; Yehudit Bergman
Journal:  Front Immunol       Date:  2014-12-05       Impact factor: 7.561
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