| Literature DB >> 9133660 |
Abstract
The DNA rearrangement that assembles antibody and T cell receptor genes is beginning to be understood. New work shows that the first step is a site-specific cleavage which can be performed by purified RAG1 and RAG2 proteins. The later steps largely overlap with the repair of radiation-induced DNA double-strand breaks, as indicated by the identity of several newly cloned factors. These developments open the way for a thorough biochemical study of V(D)J recombination.Entities:
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Year: 1996 PMID： 9133660 DOI： 10.1046/j.1365-2443.1996.22023.x
Source DB: PubMed Journal: Genes Cells ISSN： 1356-9597 Impact factor: 1.891