Literature DB >> 12227425

The cold origin of life: B. Implications based on pyrimidines and purines produced from frozen ammonium cyanide solutions.

Shin Miyakawa1, H James Cleaves, Stanley L Miller.   

Abstract

A wide variety of pyrimidines and purines were identified as products of a dilute frozen ammonium cyanide solution that had been held at -78 degrees C for 27 years. This demonstrates that both pyrimidines and purines could have been produced on the primitive earth in a short time by eutectic concentration of HCN, even though the concentration of HCN in the primitive ocean may have been low. We suggest that eutectic freezing is the most plausible demonstrated mechanism by which HCN polymerizations could have produced biologically important prebiotic compounds.

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Year:  2002        PMID: 12227425     DOI: 10.1023/a:1019514022822

Source DB:  PubMed          Journal:  Orig Life Evol Biosph        ISSN: 0169-6149            Impact factor:   1.950


  40 in total

1.  Production of guanine from NH(4)CN polymerizations.

Authors:  M Levy; S L Miller; J Oró
Journal:  J Mol Evol       Date:  1999-08       Impact factor: 2.395

2.  Submarine hot springs and the origin of life.

Authors:  S L Miller; J L Bada
Journal:  Nature       Date:  1988-08-18       Impact factor: 49.962

3.  The origin of life--did it occur at high temperatures?

Authors:  S L Miller; A Lazcano
Journal:  J Mol Evol       Date:  1995       Impact factor: 2.395

4.  Amino-acid synthesis from hydrogen cyanide under possible primitive earth conditions.

Authors:  J ORO; S S KAMAT
Journal:  Nature       Date:  1961-04-29       Impact factor: 49.962

Review 5.  Origin of life--facing up to the physical setting.

Authors:  N R Pace
Journal:  Cell       Date:  1991-05-17       Impact factor: 41.582

6.  Origin of the eukaryotic nucleus determined by rate-invariant analysis of rRNA sequences.

Authors:  J A Lake
Journal:  Nature       Date:  1988-01-14       Impact factor: 49.962

7.  Studies in prebiotic synthesis. II. Synthesis of purine precursors and amino acids from aqueous hydrogen cyanide.

Authors:  R A Sanchez; J P Ferris; L E Orgel
Journal:  J Mol Biol       Date:  1967-12-14       Impact factor: 5.469

8.  Hydrolytic stability of biomolecules at high temperatures and its implication for life at 250 degrees C.

Authors:  R H White
Journal:  Nature       Date:  1984 Aug 2-8       Impact factor: 49.962

9.  Peptide synthesis from hydrogen cyanide and water.

Authors:  C N Matthews; R E Moser
Journal:  Nature       Date:  1967-09-16       Impact factor: 49.962

10.  Uracil synthesis via HCN oligomerization.

Authors:  A B Voet; A W Schwartz
Journal:  Orig Life       Date:  1982-03
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  38 in total

1.  Ligation activity of fragmented ribozymes in frozen solution: implications for the RNA world.

Authors:  Alexander V Vlassov; Brian H Johnston; Laura F Landweber; Sergei A Kazakov
Journal:  Nucleic Acids Res       Date:  2004-05-25       Impact factor: 16.971

2.  Prebiotic adenine revisited: eutectics and photochemistry.

Authors:  Leslie E Orgel
Journal:  Orig Life Evol Biosph       Date:  2004-08       Impact factor: 1.950

3.  The TNA-family of nucleic acid systems: properties and prospects.

Authors:  Albert Eschenmoser
Journal:  Orig Life Evol Biosph       Date:  2004-06       Impact factor: 1.950

4.  Organic aerosols and the origin of life: an hypothesis.

Authors:  D J Donaldson; H Tervahattu; A F Tuck; V Vaida
Journal:  Orig Life Evol Biosph       Date:  2004-02       Impact factor: 1.950

5.  A suggested pioneer organism for the Wächtershäuser origin of life hypothesis.

Authors:  Frederick A Kundell
Journal:  Orig Life Evol Biosph       Date:  2010-06-18       Impact factor: 1.950

6.  Carbonaceous meteorites contain a wide range of extraterrestrial nucleobases.

Authors:  Michael P Callahan; Karen E Smith; H James Cleaves; Josef Ruzicka; Jennifer C Stern; Daniel P Glavin; Christopher H House; Jason P Dworkin
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-11       Impact factor: 11.205

Review 7.  The RNA world on ice: a new scenario for the emergence of RNA information.

Authors:  Alexander V Vlassov; Sergei A Kazakov; Brian H Johnston; Laura F Landweber
Journal:  J Mol Evol       Date:  2005-07-13       Impact factor: 2.395

8.  Prebiotic microreactors: a synthesis of purines and dihydroxy compounds in aqueous aerosol.

Authors:  M Ruiz-Bermejo; C Menor-Salván; S Osuna-Esteban; S Veintemillas-Verdaguer
Journal:  Orig Life Evol Biosph       Date:  2006-11-29       Impact factor: 1.950

9.  Formamide as the main building block in the origin of nucleic acids.

Authors:  Giovanna Costanzo; Raffaele Saladino; Claudia Crestini; Fabiana Ciciriello; Ernesto Di Mauro
Journal:  BMC Evol Biol       Date:  2007-08-16       Impact factor: 3.260

10.  Possible role of metal(II) octacyanomolybdate(IV) in chemical evolution: interaction with ribose nucleotides.

Authors:  Anand Kumar
Journal:  Orig Life Evol Biosph       Date:  2012-12-21       Impact factor: 1.950

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