Literature DB >> 12198182

Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase.

Petra Adam1, Stefan Hecht, Wolfgang Eisenreich, Johannes Kaiser, Tobias Grawert, Duilio Arigoni, Adelbert Bacher, Felix Rohdich.   

Abstract

Earlier in vivo studies showed the involvement of IspH protein in the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). We have demonstrated now that cell extract of an Escherichia coli strain engineered for hyperexpression of the ispH (lytB) gene catalyzes the in vitro conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into IPP and DMAPP. The reaction requires NADH, FAD, divalent cations (preferably Co2+), and probably one or more as-yet-unidentified proteins. The low intrinsic catalytic activities of wild-type E. coli cell extract and isolated chromoplasts of red pepper (Capsicum annuum) are enhanced by the addition of purified recombinant IspH protein.

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Year:  2002        PMID： 12198182      PMCID： PMC129406          DOI： 10.1073/pnas.182412599

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

1.  Studies on the nonmevalonate pathway of terpene biosynthesis. The role of 2C-methyl-D-erythritol 2,4-cyclodiphosphate in plants.

Authors:  M Fellermeier; M Raschke; S Sagner; J Wungsintaweekul; C A Schuhr; S Hecht; K Kis; T Radykewicz; P Adam; F Rohdich; W Eisenreich; A Bacher; D Arigoni; M H Zenk
Journal:  Eur J Biochem       Date:  2001-12

2.  Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

Authors:  J E Dunford; K Thompson; F P Coxon; S P Luckman; F M Hahn; C D Poulter; F H Ebetino; M J Rogers
Journal:  J Pharmacol Exp Ther       Date:  2001-02       Impact factor: 4.030

3.  Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

Authors:  H Lüttgen; F Rohdich; S Herz; J Wungsintaweekul; S Hecht; C A Schuhr; M Fellermeier; S Sagner; M H Zenk; A Bacher; W Eisenreich
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-01       Impact factor: 11.205

4.  Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein.

Authors:  S Hecht; W Eisenreich; P Adam; S Amslinger; K Kis; A Bacher; D Arigoni; F Rohdich
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-18       Impact factor: 11.205

5.  LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli.

Authors:  B Altincicek; A Kollas; M Eberl; J Wiesner; S Sanderbrand; M Hintz; E Beck; H Jomaa
Journal:  FEBS Lett       Date:  2001-06-15       Impact factor: 4.124

6.  Enzyme-assisted preparation of isotope-labeled 1-deoxy-d-xylulose 5-phosphate.

Authors:  S Hecht; K Kis; W Eisenreich; S Amslinger; J Wungsintaweekul; S Herz; F Rohdich; A Bacher
Journal:  J Org Chem       Date:  2001-06-01       Impact factor: 4.354

Review 7.  The non-mevalonate pathway of isoprenoids: genes, enzymes and intermediates.

Authors:  F Rohdich; K Kis; A Bacher; W Eisenreich
Journal:  Curr Opin Chem Biol       Date:  2001-10       Impact factor: 8.822

8.  Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein.

Authors:  Felix Rohdich; Stefan Hecht; Katrin Gärtner; Petra Adam; Cornelia Krieger; Sabine Amslinger; Duilio Arigoni; Adelbert Bacher; Wolfgang Eisenreich
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-29       Impact factor: 11.205

9.  Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol.

Authors:  F Rohdich; J Wungsintaweekul; M Fellermeier; S Sagner; S Herz; K Kis; W Eisenreich; A Bacher; M H Zenk
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-12       Impact factor: 11.205

10.  Biosynthesis of terpenes. Preparation of (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate, an intermediate of the deoxyxylulose phosphate pathway.

Authors:  Sabine Amslinger; Klaus Kis; Stefan Hecht; Petra Adam; Felix Rohdich; Duilio Arigoni; Adelbert Bacher; Wolfgang Eisenreich
Journal:  J Org Chem       Date:  2002-06-28       Impact factor: 4.354
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  48 in total

1.  Type II isopentenyl diphosphate isomerase from Synechocystis sp. strain PCC 6803.

Authors:  Sam J Barkley; Shrivallabh B Desai; C Dale Poulter
Journal:  J Bacteriol       Date:  2004-12       Impact factor: 3.490

2.  A closer look at the spectroscopic properties of possible reaction intermediates in wild-type and mutant (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase.

Authors:  Weiya Xu; Nicholas S Lees; Dominique Hall; Dhanushi Welideniya; Brian M Hoffman; Evert C Duin
Journal:  Biochemistry       Date:  2012-06-07       Impact factor: 3.162

3.  The amino-terminal conserved domain of 4-hydroxy-3-methylbut-2-enyl diphosphate reductase is critical for its function in oxygen-evolving photosynthetic organisms.

Authors:  Wei-Yu Hsieh; Ming-Hsiun Hsieh
Journal:  Plant Signal Behav       Date:  2015

4.  1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin.

Authors:  Rakesh K Dhiman; Merrill L Schaeffer; Ann Marie Bailey; Charles A Testa; Hataichanok Scherman; Dean C Crick
Journal:  J Bacteriol       Date:  2005-12       Impact factor: 3.490

Review 5.  The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target.

Authors:  Hyungjin Eoh; Patrick J Brennan; Dean C Crick
Journal:  Tuberculosis (Edinb)       Date:  2008-09-14       Impact factor: 3.131

Review 6.  An overview of the non-mevalonate pathway for terpenoid biosynthesis in plants.

Authors:  Vinod Shanker Dubey; Ritu Bhalla; Rajesh Luthra
Journal:  J Biosci       Date:  2003-09       Impact factor: 1.826

7.  The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: studies on the mechanisms of the reactions catalyzed by IspG and IspH protein.

Authors:  Felix Rohdich; Ferdinand Zepeck; Petra Adam; Stefan Hecht; Johannes Kaiser; Ralf Laupitz; Tobias Gräwert; Sabine Amslinger; Wolfgang Eisenreich; Adelbert Bacher; Duilio Arigoni
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-05       Impact factor: 11.205

8.  Feedback inhibition of deoxy-D-xylulose-5-phosphate synthase regulates the methylerythritol 4-phosphate pathway.

Authors:  Aparajita Banerjee; Yan Wu; Rahul Banerjee; Yue Li; Honggao Yan; Thomas D Sharkey
Journal:  J Biol Chem       Date:  2013-04-23       Impact factor: 5.157

9.  Bioinformatic and molecular analysis of hydroxymethylbutenyl diphosphate synthase (GCPE) gene expression during carotenoid accumulation in ripening tomato fruit.

Authors:  Manuel Rodríguez-Concepción; Jordi Querol; Luisa María Lois; Santiago Imperial; Albert Boronat
Journal:  Planta       Date:  2003-04-30       Impact factor: 4.116

10.  Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase).

Authors:  Safdar Jawaid; Heather Seidle; Weidong Zhou; Hafsa Abdirahman; Maher Abadeer; Joseph H Hix; Monique L van Hoek; Robin D Couch
Journal:  PLoS One       Date:  2009-12-14       Impact factor: 3.240
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