Literature DB >> 11375019

Enzyme-assisted preparation of isotope-labeled 1-deoxy-d-xylulose 5-phosphate.

S Hecht1, K Kis, W Eisenreich, S Amslinger, J Wungsintaweekul, S Herz, F Rohdich, A Bacher.   

Abstract

Recombinant 1-deoxy-D-xylulose 5-phosphate synthase of Bacillus subtilis was used for the preparation of isotope-labeled 1-deoxy-D-xylulose 5-phosphate using isotope-labeled glucose and/or isotope-labeled pyruvate as starting materials. The simple one-pot methods described afford almost every conceivable isotopomer of 1-deoxy-D-xylulose 5-phosphate carrying (13)C or (14)C from commercially available precursors with an overall yield around 50%.

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Year:  2001        PMID： 11375019     DOI： 10.1021/jo0100300

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  7 in total

1.  Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein.

Authors:  S Hecht; W Eisenreich; P Adam; S Amslinger; K Kis; A Bacher; D Arigoni; F Rohdich
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-18       Impact factor: 11.205

Review 2.  Biochemistry of the non-mevalonate isoprenoid pathway.

Authors:  Tobias Gräwert; Michael Groll; Felix Rohdich; Adelbert Bacher; Wolfgang Eisenreich
Journal:  Cell Mol Life Sci       Date:  2011-07-09       Impact factor: 9.261

3.  Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein.

Authors:  Felix Rohdich; Stefan Hecht; Katrin Gärtner; Petra Adam; Cornelia Krieger; Sabine Amslinger; Duilio Arigoni; Adelbert Bacher; Wolfgang Eisenreich
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-29       Impact factor: 11.205

4.  Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase.

Authors:  Petra Adam; Stefan Hecht; Wolfgang Eisenreich; Johannes Kaiser; Tobias Grawert; Duilio Arigoni; Adelbert Bacher; Felix Rohdich
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-27       Impact factor: 11.205

5.  First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization.

Authors:  Robin M Gierse; Rick Oerlemans; Eswar R Reddem; Victor O Gawriljuk; Alaa Alhayek; Dominik Baitinger; Harald Jakobi; Bernd Laber; Gudrun Lange; Anna K H Hirsch; Matthew R Groves
Journal:  Sci Rep       Date:  2022-05-04       Impact factor: 4.996

6.  Functional analysis of genes involved in the biosynthesis of isoprene in Bacillus subtilis.

Authors:  Mattijs K Julsing; Michael Rijpkema; Herman J Woerdenbag; Wim J Quax; Oliver Kayser
Journal:  Appl Microbiol Biotechnol       Date:  2007-04-26       Impact factor: 4.813

7.  Synthetic Routes to Methylerythritol Phosphate Pathway Intermediates and Downstream Isoprenoids.

Authors:  Sarah K Jarchow-Choy; Andrew T Koppisch; David T Fox
Journal:  Curr Org Chem       Date:  2014-04       Impact factor: 2.180
  7 in total

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