Literature DB >> 12182570

Azaspirene: a novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by the fungus Neosartorya sp.

Yukihiro Asami1, Hideaki Kakeya, Rie Onose, Arika Yoshida, Hiroshi Matsuzaki, Hiroyuki Osada.   

Abstract

[structure: see text] Azaspirene isolated from the fungus Neosartorya sp. is a novel angiogenesis inhibitor with a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton. Azaspirene inhibits the endothelial migration induced by vascular endothelial growth factor (ED100 = 27.1 microM).

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Year:  2002        PMID： 12182570     DOI： 10.1021/ol020104+

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  16 in total

1.  RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis.

Authors:  Hideaki Kakeya; Daisuke Kaida; Hiromi Sekiya; Koji Nagai; Minoru Yoshida; Hiroyuki Osada
Journal:  J Antibiot (Tokyo)       Date:  2015-09-09       Impact factor: 2.649

Review 2.  Strategies for mining fungal natural products.

Authors:  Philipp Wiemann; Nancy P Keller
Journal:  J Ind Microbiol Biotechnol       Date:  2013-10-22       Impact factor: 3.346

3.  Prototype of an intertwined secondary-metabolite supercluster.

Authors:  Philipp Wiemann; Chun-Jun Guo; Jonathan M Palmer; Relebohile Sekonyela; Clay C C Wang; Nancy P Keller
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-30       Impact factor: 11.205

4.  Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F058.

Authors:  Toshihiko Nogawa; Naoki Kato; Takeshi Shimizu; Akiko Okano; Yushi Futamura; Shunji Takahashi; Hiroyuki Osada
Journal:  J Antibiot (Tokyo)       Date:  2017-09-13       Impact factor: 2.649

5.  Elucidation of pseurotin biosynthetic pathway points to trans-acting C-methyltransferase: generation of chemical diversity.

Authors:  Yuta Tsunematsu; Manami Fukutomi; Takayoshi Saruwatari; Hiroshi Noguchi; Kinya Hotta; Yi Tang; Kenji Watanabe
Journal:  Angew Chem Int Ed Engl       Date:  2014-06-18       Impact factor: 15.336

6.  Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation.

Authors:  Yukihiro Asami; Hideaki Kakeya; Yusuke Komi; Soichi Kojima; Kiyohiro Nishikawa; Kristin Beebe; Len Neckers; Hiroyuki Osada
Journal:  Cancer Sci       Date:  2008-07-10       Impact factor: 6.716

7.  A photoisomerization-coupled asymmetric Stetter reaction: application to the total synthesis of three diastereomers of (-)-cephalimysin A.

Authors:  Stephen P Lathrop; Tomislav Rovis
Journal:  Chem Sci       Date:  2013-04       Impact factor: 9.825

8.  Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis.

Authors:  Tsuyoshi Yamamoto; Yuta Tsunematsu; Kodai Hara; Tomohiro Suzuki; Shinji Kishimoto; Hirokazu Kawagishi; Hiroshi Noguchi; Hiroshi Hashimoto; Yi Tang; Kinya Hotta; Kenji Watanabe
Journal:  Angew Chem Int Ed Engl       Date:  2016-04-13       Impact factor: 15.336

9.  Exploring the chemodiversity and biological activities of the secondary metabolites from the marine fungus Neosartorya pseudofischeri.

Authors:  Wan-Ling Liang; Xiu Le; Hou-Jin Li; Xiang-Ling Yang; Jun-Xiong Chen; Jun Xu; Huan-Liang Liu; Lai-You Wang; Kun-Teng Wang; Kun-Chao Hu; De-Po Yang; Wen-Jian Lan
Journal:  Mar Drugs       Date:  2014-11-24       Impact factor: 5.118

10.  Methylation-dependent acyl transfer between polyketide synthase and nonribosomal peptide synthetase modules in fungal natural product biosynthesis.

Authors:  Yi Zou; Wei Xu; Yuta Tsunematsu; Mancheng Tang; Kenji Watanabe; Yi Tang
Journal:  Org Lett       Date:  2014-12-10       Impact factor: 6.005
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