Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis.

Literature DB >> 26350783

RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis.

Hideaki Kakeya^1,2, Daisuke Kaida^3,4, Hiromi Sekiya¹, Koji Nagai⁵, Minoru Yoshida³, Hiroyuki Osada¹.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2015 PMID： 26350783 DOI： 10.1038/ja.2015.94

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

× No keyword cloud information.

24 in total

1. Epoxyquinol B, a fungal metabolite with a potent antiangiogenic activity.

Authors: Hideaki Kakeya; Rie Onose; Arika Yoshida; Hiroyuki Koshino; Hiroyuki Osada
Journal: J Antibiot (Tokyo) Date: 2002-09 Impact factor: 2.649

2. Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product.

Authors: Makoto Hasegawa; Tatsuhiro Miura; Kouji Kuzuya; Ayu Inoue; Se Won Ki; Sueharu Horinouchi; Tetsuo Yoshida; Tatsuki Kunoh; Koichi Koseki; Koshiki Mino; Ryuzo Sasaki; Minoru Yoshida; Tamio Mizukami
Journal: ACS Chem Biol Date: 2011-01-13 Impact factor: 5.100

Review 3. Predicting benefit from anti-angiogenic agents in malignancy.

Authors: Adrian M Jubb; Adam J Oates; Scott Holden; Hartmut Koeppen
Journal: Nat Rev Cancer Date: 2006-07-13 Impact factor: 60.716

4. Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus.

Authors: Hideaki Kakeya; Rie Onose; Hiroyuki Koshino; Hiroyuki Osada
Journal: Chem Commun (Camb) Date: 2005-03-15 Impact factor: 6.222

5. Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites.

Authors: Hideaki Kakeya; Rie Onose; Hiroyuki Koshino; Arika Yoshida; Kimiko Kobayashi; Shun-Ichiro Kageyama; Hiroyuki Osada
Journal: J Am Chem Soc Date: 2002-04-10 Impact factor: 15.419

RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis.

1. Epoxyquinol B, a fungal metabolite with a potent antiangiogenic activity.

2. Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product.

Review 3. Predicting benefit from anti-angiogenic agents in malignancy.

4. Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus.

5. Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites.

6. Biosynthetic origins of the epoxyquinone skeleton in epoxyquinols A and B.

Review 7. Splicing in oncogenesis and tumor suppression.

8. Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1.

Review 9. The spliceosome as a target of novel antitumour drugs.

10. Splicing factor SF3b as a target of the antitumor natural product pladienolide.

Review 1. Modulating splicing with small molecular inhibitors of the spliceosome.

Review 2. Biology of the mRNA Splicing Machinery and Its Dysregulation in Cancer Providing Therapeutic Opportunities.

Review 3. Splicing modulators: on the way from nature to clinic.