Literature DB >> 12137510

Reactions of methane monooxygenase intermediate Q with derivatized methanes.

Edna A Ambundo1, Richard A Friesner, Stephen J Lippard.   

Abstract

The reactivity of intermediate Q of soluble methane monooxygenase from Methylococcus capsulatus (Bath) with a series of derivatized methanes of general formula CH3-R, where R = CN, NO2, and OH, and their deuterated analogues is described. Despite relatively slow reactions, significant kinetic isotope effects, KIEs, are observed in reactions with acetonitrile and nitromethane; however, none is obtained with methanol. In addition, evidence of a substrate-binding step that occurs prior to substrate oxidation is observed.

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Year:  2002        PMID： 12137510     DOI： 10.1021/ja0265759

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  17 in total

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4.  Oxidation reactions performed by soluble methane monooxygenase hydroxylase intermediates H(peroxo) and Q proceed by distinct mechanisms.

Authors:  Christine E Tinberg; Stephen J Lippard
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5.  Molecular-Level Insight into the Differential Oxidase and Oxygenase Reactivities of de Novo Due Ferri Proteins.

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6.  Revisiting the mechanism of dioxygen activation in soluble methane monooxygenase from M. capsulatus (Bath): evidence for a multi-step, proton-dependent reaction pathway.

Authors:  Christine E Tinberg; Stephen J Lippard
Journal:  Biochemistry       Date:  2009-12-29       Impact factor: 3.162

7.  Quantitative production of compound I from a cytochrome P450 enzyme at low temperatures. Kinetics, activation parameters, and kinetic isotope effects for oxidation of benzyl alcohol.

Authors:  Qin Wang; Xin Sheng; John H Horner; Martin Newcomb
Journal:  J Am Chem Soc       Date:  2009-08-05       Impact factor: 15.419

8.  Tunneling in C-H oxidation reactions by an oxoiron(IV) porphyrin radical cation: direct measurements of very large H/D kinetic isotope effects.

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Journal:  J Am Chem Soc       Date:  2008-05-31       Impact factor: 15.419

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10.  Aqueous phase C-H bond oxidation reaction of arylalkanes catalyzed by a water-soluble cationic Ru(III) complex [(pymox-Me2)2RuCl2]+BF4-.

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Journal:  Org Lett       Date:  2009-04-02       Impact factor: 6.005
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