Literature DB >> 12127775

X-chromosome inactivation: closing in on proteins that bind Xist RNA.

Neil Brockdorff1.   

Abstract

X inactivation is the developmentally regulated silencing of a single X chromosome in XX female mammals. In recent years, the Xist gene has been revealed as the master regulatory switch controlling this process. Parental imprinting and/or counting mechanisms ensure that Xist is expressed only on the inactive X chromosome. Chromosome silencing then results from the accumulation of the Xist RNA silencing signal, in cis, over the entire length of the X chromosome. A key issue has been to identify the factors that interact with Xist RNA to initiate heritable gene silencing. This review discusses recent progress that has put this goal in sight.

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Year:  2002        PMID： 12127775     DOI： 10.1016/s0168-9525(02)02717-8

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  30 in total

1.  Comparative analysis of the primate X-inactivation center region and reconstruction of the ancestral primate XIST locus.

Authors:  Julie E Horvath; Christina B Sheedy; Stephanie L Merrett; Abdoulaye Banire Diallo; David L Swofford; Eric D Green; Huntington F Willard
Journal:  Genome Res       Date:  2011-04-25       Impact factor: 9.043

2.  Expression of T cell receptor beta locus in central nervous system neurons.

Authors:  Josh Syken; Carla J Shatz
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-20       Impact factor: 11.205

3.  Transcriptional activation of a constitutive heterochromatic domain of the human genome in response to heat shock.

Authors:  Nicoletta Rizzi; Marco Denegri; Ilaria Chiodi; Margherita Corioni; Rut Valgardsdottir; Fabio Cobianchi; Silvano Riva; Giuseppe Biamonti
Journal:  Mol Biol Cell       Date:  2003-11-14       Impact factor: 4.138

Review 4.  Long non-coding RNAs in corticogenesis: deciphering the non-coding code of the brain.

Authors:  Julieta Aprea; Federico Calegari
Journal:  EMBO J       Date:  2015-10-29       Impact factor: 11.598

5.  Differentiation-induced replication-timing changes are restricted to AT-rich/long interspersed nuclear element (LINE)-rich isochores.

Authors:  Ichiro Hiratani; Amanda Leskovar; David M Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  2004-11-19       Impact factor: 11.205

6.  An expectation-maximization algorithm for the analysis of allelic expression imbalance.

Authors:  M D Teare; J Heighway; M F Santibáñez Koref
Journal:  Am J Hum Genet       Date:  2006-06-30       Impact factor: 11.025

7.  Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation.

Authors:  Fabio Savarese; Katja Flahndorfer; Rudolf Jaenisch; Meinrad Busslinger; Anton Wutz
Journal:  Mol Cell Biol       Date:  2006-10       Impact factor: 4.272

8.  Difference between random and imprinted X inactivation in common voles.

Authors:  Elena V Dementyeva; Alexander I Shevchenko; Olga V Anopriyenko; Nina A Mazurok; Eugeny A Elisaphenko; Tatyana B Nesterova; Neil Brockdorff; Suren M Zakian
Journal:  Chromosoma       Date:  2010-05-15       Impact factor: 4.316

Review 9.  Epigenetics, aging, and autoimmunity.

Authors:  Raymond L Yung; Annabelle Julius
Journal:  Autoimmunity       Date:  2008-05       Impact factor: 2.815

10.  2-D structure of the A region of Xist RNA and its implication for PRC2 association.

Authors:  Sylvain Maenner; Magali Blaud; Laetitia Fouillen; Anne Savoye; Virginie Marchand; Agnès Dubois; Sarah Sanglier-Cianférani; Alain Van Dorsselaer; Philippe Clerc; Philip Avner; Athanase Visvikis; Christiane Branlant
Journal:  PLoS Biol       Date:  2010-01-05       Impact factor: 8.029
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