Literature DB >> 12121946

The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes.

Elizabeth Pradel1, Jean-Marie Pagès.   

Abstract

We identified the genes encoding the AcrA-AcrB-TolC efflux pump in Enterobacter aerogenes and constructed acrAB and tolC mutants from a multidrug-resistant isolate. Both derivatives were more susceptible to antibiotics than the parental strain. Sequence analysis and complementation experiments revealed that the multidrug-resistant isolate is an acrR mutant.

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Year:  2002        PMID： 12121946      PMCID： PMC127391          DOI： 10.1128/AAC.46.8.2640-2643.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  National Nosocomial Infections Surveillance (NNIS) System Report, Data Summary from January 1990-May 1999, issued June 1999. A report from the NNIS System.

Authors: 
Journal:  Am J Infect Control       Date:  1999-12       Impact factor: 2.918

Review 2.  The mar regulon: multiple resistance to antibiotics and other toxic chemicals.

Authors:  M N Alekshun; S B Levy
Journal:  Trends Microbiol       Date:  1999-10       Impact factor: 17.079

3.  High-level fluoroquinolone-resistant clinical isolates of Escherichia coli overproduce multidrug efflux protein AcrA.

Authors:  A Mazzariol; Y Tokue; T M Kanegawa; G Cornaglia; H Nikaido
Journal:  Antimicrob Agents Chemother       Date:  2000-12       Impact factor: 5.191

4.  Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export.

Authors:  V Koronakis; A Sharff; E Koronakis; B Luisi; C Hughes
Journal:  Nature       Date:  2000-06-22       Impact factor: 49.962

5.  The TolC protein of Escherichia coli serves as a cell-surface receptor for the newly characterized TLS bacteriophage.

Authors:  G J German; R Misra
Journal:  J Mol Biol       Date:  2001-05-11       Impact factor: 5.469

Review 6.  Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria.

Authors:  K Poole
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

7.  Absence of mutations in marRAB or soxRS in acrB-overexpressing fluoroquinolone-resistant clinical and veterinary isolates of Escherichia coli.

Authors:  M A Webber; L J Piddock
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

8.  Genetic characterization of highly fluoroquinolone-resistant clinical Escherichia coli strains from China: role of acrR mutations.

Authors:  H Wang; J L Dzink-Fox; M Chen; S B Levy
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

9.  Porin alteration and active efflux: two in vivo drug resistance strategies used by Enterobacter aerogenes.

Authors:  Monique Mallea; Jacqueline Chevalier; Charleric Bornet; Annie Eyraud; Anne Davin-Regli; Claude Bollet; Jean-Marie Pages
Journal:  Microbiology (Reading)       Date:  1998-11       Impact factor: 2.777

10.  AcrA is a highly asymmetric protein capable of spanning the periplasm.

Authors:  H I Zgurskaya; H Nikaido
Journal:  J Mol Biol       Date:  1999-01-08       Impact factor: 5.469
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  63 in total

1.  Omp35, a new Enterobacter aerogenes porin involved in selective susceptibility to cephalosporins.

Authors:  Charléric Bornet; Nathalie Saint; Lilia Fetnaci; Myrielle Dupont; Anne Davin-Régli; Claude Bollet; Jean-Marie Pagès
Journal:  Antimicrob Agents Chemother       Date:  2004-06       Impact factor: 5.191

2.  Genetic and molecular characterization of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae with unusually high resistance to ampicillin.

Authors:  Frank S Kaczmarek; Thomas D Gootz; Fadia Dib-Hajj; Wenchi Shang; Shawn Hallowell; Melissa Cronan
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

3.  Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.

Authors:  Victor Kuete; Bathélémy Ngameni; Jean G Tangmouo; Jean-Michel Bolla; Sandrine Alibert-Franco; Bonaventure T Ngadjui; Jean-Marie Pagès
Journal:  Antimicrob Agents Chemother       Date:  2010-02-16       Impact factor: 5.191

Review 4.  Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria.

Authors:  Laura J V Piddock
Journal:  Clin Microbiol Rev       Date:  2006-04       Impact factor: 26.132

5.  Geraniol restores antibiotic activities against multidrug-resistant isolates from gram-negative species.

Authors:  Vannina Lorenzi; Alain Muselli; Antoine François Bernardini; Liliane Berti; Jean-Marie Pagès; Leonard Amaral; Jean-Michel Bolla
Journal:  Antimicrob Agents Chemother       Date:  2009-03-02       Impact factor: 5.191

Review 6.  The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Authors:  Xian-Zhi Li; Patrick Plésiat; Hiroshi Nikaido
Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

7.  Spectrofluorimetric quantification of antibiotic drug concentration in bacterial cells for the characterization of translocation across bacterial membranes.

Authors:  Julia Vergalli; Estelle Dumont; Jelena Pajović; Bertrand Cinquin; Laure Maigre; Muriel Masi; Matthieu Réfrégiers; Jean-Marie Pagés
Journal:  Nat Protoc       Date:  2018-05-17       Impact factor: 13.491

8.  Activities of selected medicinal plants against multi-drug resistant Gram-negative bacteria in Cameroon.

Authors:  Marthe E S Tchana; Aimé G Fankam; Armelle T Mbaveng; Ernestine T Nkwengoua; Jackson A Seukep; Francesco K Tchouani; Barthélémy Nyassé; Victor Kuete
Journal:  Afr Health Sci       Date:  2014-03       Impact factor: 0.927

9.  The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli.

Authors:  Renaud Chollet; Jacqueline Chevalier; André Bryskier; Jean-Marie Pagès
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191

10.  New antibiotic molecules: bypassing the membrane barrier of gram negative bacteria increases the activity of peptide deformylase inhibitors.

Authors:  Laurent Mamelli; Sylvain Petit; Jacqueline Chevalier; Carmela Giglione; Aurélie Lieutaud; Thierry Meinnel; Isabelle Artaud; Jean-Marie Pagès
Journal:  PLoS One       Date:  2009-07-30       Impact factor: 3.240
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