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Literature DB >> 11302826

Absence of mutations in marRAB or soxRS in acrB-overexpressing fluoroquinolone-resistant clinical and veterinary isolates of Escherichia coli.

Abstract

The amount of acrB, marA, and soxS mRNA was determined in 36 fluoroquinolone-resistant E. coli from humans and animals, 27 of which displayed a multiple-resistance phenotype. acrB mRNA was elevated in 11 of 36 strains. A mutation at codon 45 (Arg-->Cys) in acrR was found in 6 of these 11 strains. Ten of the 36 isolates appeared to overexpress soxS, and five appeared to overexpress marA. A number of mutations were found in the marR and soxR repressor genes, correlating with greater amounts of marA and soxS mRNA, respectively.

Entities: Chemical Species

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Year: 2001 PMID： 11302826 PMCID： PMC90504 DOI： 10.1128/AAC.45.5.1550-1552.2001

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

21 in total

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Authors: R G Martin; W K Gillette; J L Rosner
Journal: Mol Microbiol Date: 2000-02 Impact factor: 3.501

2. Two efflux systems expressed simultaneously in multidrug-resistant Pseudomonas aeruginosa.

Authors: L Pumbwe; L J Piddock
Journal: Antimicrob Agents Chemother Date: 2000-10 Impact factor: 5.191

3. Molecular characterization of the soxRS genes of Escherichia coli: two genes control a superoxide stress regulon.

Authors: C F Amábile-Cuevas; B Demple
Journal: Nucleic Acids Res Date: 1991-08-25 Impact factor: 16.971

Review 4. Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon.

Authors: M N Alekshun; S B Levy
Journal: Antimicrob Agents Chemother Date: 1997-10 Impact factor: 5.191

5. Defining a rob regulon in Escherichia coli by using transposon mutagenesis.

Authors: M H Bennik; P J Pomposiello; D F Thorne; B Demple
Journal: J Bacteriol Date: 2000-07 Impact factor: 3.490

6. Differential expression of over 60 chromosomal genes in Escherichia coli by constitutive expression of MarA.

Authors: T M Barbosa; S B Levy
Journal: J Bacteriol Date: 2000-06 Impact factor: 3.490

7. Molecular cloning and characterization of acrA and acrE genes of Escherichia coli.

Authors: D Ma; D N Cook; M Alberti; N G Pon; H Nikaido; J E Hearst
Journal: J Bacteriol Date: 1993-10 Impact factor: 3.490

8. A novel binding protein of the origin of the Escherichia coli chromosome.

Authors: K Skarstad; B Thöny; D S Hwang; A Kornberg
Journal: J Biol Chem Date: 1993-03-15 Impact factor: 5.157

9. Overexpression of the marA or soxS regulatory gene in clinical topoisomerase mutants of Escherichia coli.

Authors: M Oethinger; I Podglajen; W V Kern; S B Levy
Journal: Antimicrob Agents Chemother Date: 1998-08 Impact factor: 5.191

10. Gene in the major cotransduction gap of the Escherichia coli K-12 linkage map required for the expression of chromosomal resistance to tetracycline and other antibiotics.

Authors: A M George; S B Levy
Journal: J Bacteriol Date: 1983-08 Impact factor: 3.490

43 in total

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Authors: Elizabeth Pradel; Jean-Marie Pagès
Journal: Antimicrob Agents Chemother Date: 2002-08 Impact factor: 5.191

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Journal: Antimicrob Agents Chemother Date: 2015-12-14 Impact factor: 5.191

3. Contribution of mutation at amino acid 45 of AcrR to acrB expression and ciprofloxacin resistance in clinical and veterinary Escherichia coli isolates.

Authors: Mark A Webber; Ashraf Talukder; Laura J V Piddock
Journal: Antimicrob Agents Chemother Date: 2005-10 Impact factor: 5.191

Review 4. Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria.

Authors: Laura J V Piddock
Journal: Clin Microbiol Rev Date: 2006-04 Impact factor: 26.132

5. Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications.

Authors: Hervé Nicoloff; Vincent Perreten; Stuart B Levy
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