Literature DB >> 11083655

High-level fluoroquinolone-resistant clinical isolates of Escherichia coli overproduce multidrug efflux protein AcrA.

A Mazzariol1, Y Tokue, T M Kanegawa, G Cornaglia, H Nikaido.   

Abstract

Immunoblotting with antibody against AcrA, an obligatory component of the AcrAB multidrug efflux system, showed that this protein was overexpressed by >/=170% in 9 of 10 clinical isolates of Esherichia coli with high-level ciprofloxacin resistance (MICs, >/=32 microg/ml) but not in any of the 15 isolates for which the MIC was </=1 microg/ml.

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Year:  2000        PMID： 11083655      PMCID： PMC90220          DOI： 10.1128/AAC.44.12.3441-3443.2000

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin.

Authors:  T E Renau; R Léger; E M Flamme; J Sangalang; M W She; R Yen; C L Gannon; D Griffith; S Chamberland; O Lomovskaya; S J Hecker; V J Lee; T Ohta; K Nakayama
Journal:  J Med Chem       Date:  1999-12-02       Impact factor: 7.446

Review 2.  Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon.

Authors:  M N Alekshun; S B Levy
Journal:  Antimicrob Agents Chemother       Date:  1997-10       Impact factor: 5.191

3.  Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.

Authors:  M J Everett; Y F Jin; V Ricci; L J Piddock
Journal:  Antimicrob Agents Chemother       Date:  1996-10       Impact factor: 5.191

4.  Association of organic solvent tolerance and fluoroquinolone resistance in clinical isolates of Escherichia coli.

Authors:  M Oethinger; W V Kern; J D Goldman; S B Levy
Journal:  J Antimicrob Chemother       Date:  1998-01       Impact factor: 5.790

5.  Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli.

Authors:  H I Zgurskaya; H Nikaido
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-22       Impact factor: 11.205

Review 6.  Bacterial topoisomerases, anti-topoisomerases, and anti-topoisomerase resistance.

Authors:  D C Hooper
Journal:  Clin Infect Dis       Date:  1998-08       Impact factor: 9.079

7.  Quinolone-resistant mutants of escherichia coli DNA topoisomerase IV parC gene.

Authors:  Y Kumagai; J I Kato; K Hoshino; T Akasaka; K Sato; H Ikeda
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

8.  Overexpression of the marA or soxS regulatory gene in clinical topoisomerase mutants of Escherichia coli.

Authors:  M Oethinger; I Podglajen; W V Kern; S B Levy
Journal:  Antimicrob Agents Chemother       Date:  1998-08       Impact factor: 5.191

9.  Topoisomerase IV is a target of quinolones in Escherichia coli.

Authors:  A B Khodursky; E L Zechiedrich; N R Cozzarelli
Journal:  Proc Natl Acad Sci U S A       Date:  1995-12-05       Impact factor: 11.205

10.  AcrA is a highly asymmetric protein capable of spanning the periplasm.

Authors:  H I Zgurskaya; H Nikaido
Journal:  J Mol Biol       Date:  1999-01-08       Impact factor: 5.469
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  42 in total

1.  The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes.

Authors:  Elizabeth Pradel; Jean-Marie Pagès
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

Review 2.  Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria.

Authors:  Laura J V Piddock
Journal:  Clin Microbiol Rev       Date:  2006-04       Impact factor: 26.132

3.  Growth phase-dependent expression of drug exporters in Escherichia coli and its contribution to drug tolerance.

Authors:  Asuka Kobayashi; Hidetada Hirakawa; Takahiro Hirata; Kunihiko Nishino; Akihito Yamaguchi
Journal:  J Bacteriol       Date:  2006-08       Impact factor: 3.490

4.  Overexpression of the multidrug efflux operon acrEF by insertional activation with IS1 or IS10 elements in Salmonella enterica serovar typhimurium DT204 acrB mutants selected with fluoroquinolones.

Authors:  Anne Olliver; Michel Vallé; Elisabeth Chaslus-Dancla; Axel Cloeckaert
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

5.  Correlation of overexpression of efflux pump genes with antibiotic resistance in Escherichia coli Strains clinically isolated from urinary tract infection patients.

Authors:  Tomihiko Yasufuku; Katsumi Shigemura; Toshiro Shirakawa; Minori Matsumoto; Yuzo Nakano; Kazushi Tanaka; Soichi Arakawa; Shouhiro Kinoshita; Masato Kawabata; Masato Fujisawa
Journal:  J Clin Microbiol       Date:  2010-11-03       Impact factor: 5.948

6.  Catabolism of aromatic β-glucosides by bacteria can lead to antibiotics resistance.

Authors:  Kartika Vashishtha; S Mahadevan
Journal:  Arch Microbiol       Date:  2020-03-04       Impact factor: 2.552

Review 7.  Emergence of antibiotic-resistant extremophiles (AREs).

Authors:  Prashant Gabani; Dhan Prakash; Om V Singh
Journal:  Extremophiles       Date:  2012-08-21       Impact factor: 2.395

Review 8.  Multidrug resistance in bacteria.

Authors:  Hiroshi Nikaido
Journal:  Annu Rev Biochem       Date:  2009       Impact factor: 23.643

9.  AcrAB-TolC directs efflux-mediated multidrug resistance in Salmonella enterica serovar typhimurium DT104.

Authors:  Sylvie Baucheron; Shaun Tyler; David Boyd; Michael R Mulvey; Elisabeth Chaslus-Dancla; Axel Cloeckaert
Journal:  Antimicrob Agents Chemother       Date:  2004-10       Impact factor: 5.191

10.  Plasmid-encoded multidrug efflux pump conferring resistance to olaquindox in Escherichia coli.

Authors:  Lars Hestbjerg Hansen; Elsebetta Johannesen; Mette Burmølle; Anders Hay Sørensen; Søren J Sørensen
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191
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