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Literature DB >> 15328143

The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli.

Renaud Chollet¹, Jacqueline Chevalier, André Bryskier, Jean-Marie Pagès.

Abstract

The role of the AcrAB-TolC pump in macrolide and ketolide susceptibility in Escherichia coli and Enterobacter aerogenes was studied. Efflux pump inhibitor restored erythromycin, clarithromycin, and telithromycin susceptibilities to multidrug-resistant isolates. No modification of telithromycin accumulation was detected in E. aerogenes acrAB or tolC derivatives compared to that in the parental strain. Two independent efflux pumps, inhibited by phenylalanine arginine beta-naphthylamide, expel macrolides and telithromycin in E. aerogenes.

Entities: Chemical Gene Species

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Year: 2004 PMID： 15328143 PMCID： PMC514773 DOI： 10.1128/AAC.48.9.3621-3624.2004

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

23 in total

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Journal: Antimicrob Agents Chemother Date: 1999-12 Impact factor: 5.191

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Journal: J Appl Microbiol Date: 2002 Impact factor: 3.772

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Authors: Elizabeth Pradel; Jean-Marie Pagès
Journal: Antimicrob Agents Chemother Date: 2002-08 Impact factor: 5.191

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Journal: Microbiology (Reading) Date: 1998-03 Impact factor: 2.777

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Authors: Roland Leclercq
Journal: Clin Infect Dis Date: 2002-01-11 Impact factor: 9.079

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Journal: Int J Antimicrob Agents Date: 2001 Impact factor: 5.283

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Authors: N Kobayashi; K Nishino; A Yamaguchi
Journal: J Bacteriol Date: 2001-10 Impact factor: 3.490

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Authors: L Sánchez; W Pan; M Viñas; H Nikaido
Journal: J Bacteriol Date: 1997-11 Impact factor: 3.490

9. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy.

Authors: O Lomovskaya; M S Warren; A Lee; J Galazzo; R Fronko; M Lee; J Blais; D Cho; S Chamberland; T Renau; R Leger; S Hecker; W Watkins; K Hoshino; H Ishida; V J Lee
Journal: Antimicrob Agents Chemother Date: 2001-01 Impact factor: 5.191

Review 10. Ketolides-telithromycin, an example of a new class of antibacterial agents.

Authors: A Bryskier
Journal: Clin Microbiol Infect Date: 2000-12 Impact factor: 8.067

35 in total

1. Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.

Authors: Victor Kuete; Bathélémy Ngameni; Jean G Tangmouo; Jean-Michel Bolla; Sandrine Alibert-Franco; Bonaventure T Ngadjui; Jean-Marie Pagès
Journal: Antimicrob Agents Chemother Date: 2010-02-16 Impact factor: 5.191

Review 2. Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria.

Authors: Laura J V Piddock
Journal: Clin Microbiol Rev Date: 2006-04 Impact factor: 26.132

3. A fluorescent microplate assay quantifies bacterial efflux and demonstrates two distinct compound binding sites in AcrB.

Authors: Ramkumar Iyer; Annette Ferrari; R Rijnbrand; Alice L Erwin
Journal: Antimicrob Agents Chemother Date: 2015-02-02 Impact factor: 5.191

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Authors: Xian-Zhi Li; Hiroshi Nikaido
Journal: Drugs Date: 2009-08-20 Impact factor: 9.546

Review 5. Xenobiotic efflux in bacteria and fungi: a genomics update.

Authors: Ravi D Barabote; Jose Thekkiniath; Richard E Strauss; Govindsamy Vediyappan; Joe A Fralick; Michael J San Francisco
Journal: Adv Enzymol Relat Areas Mol Biol Date: 2011

6. Structure-activity relationships of potentiators of the antibiotic activity of clarithromycin against Escherichia coli.

Authors: Gifty Blankson; Ajit K Parhi; Malvika Kaul; Daniel S Pilch; Edmond J LaVoie
Journal: Eur J Med Chem Date: 2019-05-29 Impact factor: 6.514

Review 7. The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Authors: Xian-Zhi Li; Patrick Plésiat; Hiroshi Nikaido
Journal: Clin Microbiol Rev Date: 2015-04 Impact factor: 26.132

8. Azithromycin effectiveness against intracellular infections of Francisella.

Authors: Saira Ahmad; Lyman Hunter; Aiping Qin; Barbara J Mann; Monique L van Hoek
Journal: BMC Microbiol Date: 2010-04-23 Impact factor: 3.605

9. Genetic exchange of multidrug efflux pumps among two enterobacterial species with distinctive ecological Niches.

Authors: Nehaya Al-Karablieh; Helge Weingart; Matthias S Ullrich
Journal: Int J Mol Sci Date: 2009-02-19 Impact factor: 6.208

10. New antibiotic molecules: bypassing the membrane barrier of gram negative bacteria increases the activity of peptide deformylase inhibitors.

Authors: Laurent Mamelli; Sylvain Petit; Jacqueline Chevalier; Carmela Giglione; Aurélie Lieutaud; Thierry Meinnel; Isabelle Artaud; Jean-Marie Pagès
Journal: PLoS One Date: 2009-07-30 Impact factor: 3.240