Literature DB >> 12045256

Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity.

Yujin Shuto1, Tamotsu Shibasaki, Asuka Otagiri, Hideki Kuriyama, Hisayuki Ohata, Hideki Tamura, Jun Kamegai, Hitoshi Sugihara, Shinichi Oikawa, Ichiji Wakabayashi.   

Abstract

Growth hormone secretagogues (GHSs) stimulate GH secretion and food intake. GHS receptor (GHS-R) mRNA has been identified mainly in the arcuate nucleus (Arc) and ventromedial nucleus of the hypothalamus and in the pituitary. Ghrelin, an endogenous ligand for GHS-R, has recently been purified from rat stomach. Although ghrelin is also expressed in the hypothalamus, the physiological significance of the ghrelin/GHS-R system is still unknown. We have created transgenic (Tg) rats expressing an antisense GHS-R mRNA under the control of the promoter for tyrosine hydroxylase (TH), thus selectively attenuating GHS-R protein expression in the Arc. Tg rats had lower body weight and less adipose tissue than did control rats. Daily food intake was reduced, and the stimulatory effect of GHS treatment on feeding was abolished in Tg rats. GH secretion and plasma insulin-like growth factor-I levels were reduced in female Tg rats. These results suggest that GHS-R in the Arc is involved in the regulation of GH secretion, food intake, and adiposity.

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Year:  2002        PMID： 12045256      PMCID： PMC150991          DOI： 10.1172/JCI13300

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  36 in total

1.  Injection of anti-neuropeptide Y gamma-globulin into the hypothalamic paraventricular nucleus decreases food intake in rats.

Authors:  T Shibasaki; T Oda; T Imaki; N Ling; H Demura
Journal:  Brain Res       Date:  1993-01-22       Impact factor: 3.252

Review 2.  Peptidomimetic regulation of growth hormone secretion.

Authors:  R G Smith; L H Van der Ploeg; A D Howard; S D Feighner; K Cheng; G J Hickey; M J Wyvratt; M H Fisher; R P Nargund; A A Patchett
Journal:  Endocr Rev       Date:  1997-10       Impact factor: 19.871

3.  Intracerebroventricular administration of the growth hormone-releasing peptide KP-102 increases food intake in free-feeding rats.

Authors:  K Okada; S Ishii; S Minami; H Sugihara; T Shibasaki; I Wakabayashi
Journal:  Endocrinology       Date:  1996-11       Impact factor: 4.736

4.  Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues.

Authors:  X M Guan; H Yu; O C Palyha; K K McKee; S D Feighner; D J Sirinathsinghji; R G Smith; L H Van der Ploeg; A D Howard
Journal:  Brain Res Mol Brain Res       Date:  1997-08

5.  Induction of c-fos messenger ribonucleic acid in neuropeptide Y and growth hormone (GH)-releasing factor neurons in the rat arcuate nucleus following systemic injection of the GH secretagogue, GH-releasing peptide-6.

Authors:  S L Dickson; S M Luckman
Journal:  Endocrinology       Date:  1997-02       Impact factor: 4.736

6.  The growth hormone-releasing peptide KP-102 induces c-fos expression in the arcuate nucleus.

Authors:  J Kamegai; O Hasegawa; S Minami; H Sugihara; I Wakabayashi
Journal:  Brain Res Mol Brain Res       Date:  1996-07

7.  Downregulation of RAR alpha in mice by antisense transgene leads to a compensatory increase in RAR beta and RAR gamma and development of lymphoma.

Authors:  T Manshouri; Y Yang; H Lin; S A Stass; A B Glassman; M J Keating; M Albitar
Journal:  Blood       Date:  1997-04-01       Impact factor: 22.113

8.  DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype.

Authors:  S A Banerjee; S Roffler-Tarlov; M Szabo; L Frohman; D M Chikaraishi
Journal:  Brain Res Mol Brain Res       Date:  1994-07

9.  Induction of G alpha i2-specific antisense RNA in vivo inhibits neonatal growth.

Authors:  C M Moxham; Y Hod; C C Malbon
Journal:  Science       Date:  1993-05-14       Impact factor: 47.728

10.  A receptor in pituitary and hypothalamus that functions in growth hormone release.

Authors:  A D Howard; S D Feighner; D F Cully; J P Arena; P A Liberator; C I Rosenblum; M Hamelin; D L Hreniuk; O C Palyha; J Anderson; P S Paress; C Diaz; M Chou; K K Liu; K K McKee; S S Pong; L Y Chaung; A Elbrecht; M Dashkevicz; R Heavens; M Rigby; D J Sirinathsinghji; D C Dean; D G Melillo; A A Patchett; R Nargund; P R Griffin; J A DeMartino; S K Gupta; J M Schaeffer; R G Smith; L H Van der Ploeg
Journal:  Science       Date:  1996-08-16       Impact factor: 47.728
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  65 in total

Review 1.  Control of body weight: a physiologic and transgenic perspective.

Authors:  G Frühbeck; J Gómez-Ambrosi
Journal:  Diabetologia       Date:  2003-02-15       Impact factor: 10.122

Review 2.  Ghrelin: new molecular pathways modulating appetite and adiposity.

Authors:  Ruben Nogueiras; Lynda M Williams; Carlos Dieguez
Journal:  Obes Facts       Date:  2010-10-04       Impact factor: 3.942

Review 3.  Peripheral regulation of food intake: new insights.

Authors:  O Ukkola
Journal:  J Endocrinol Invest       Date:  2004-01       Impact factor: 4.256

Review 4.  Leptin and ghrelin: what is the impact on pituitary function?

Authors:  Felipe F Casanueva; Carlos Dieguez
Journal:  Rev Endocr Metab Disord       Date:  2005-01       Impact factor: 6.514

5.  In search of an effective obesity treatment: a shot in the dark or a shot in the arm?

Authors:  Jeffrey M Zigman; Joel K Elmquist
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-21       Impact factor: 11.205

6.  Determinants of dual secretagogue drive of burst-like growth hormone secretion in premenopausal women studied under a selective estradiol clamp.

Authors:  Dana Erickson; Daniel M Keenan; Leon Farhy; Kristi Mielke; Cyril Y Bowers; Johannes D Veldhuis
Journal:  J Clin Endocrinol Metab       Date:  2004-12-21       Impact factor: 5.958

7.  Mice lacking ghrelin receptors resist the development of diet-induced obesity.

Authors:  Jeffrey M Zigman; Yoshihide Nakano; Roberto Coppari; Nina Balthasar; Jacob N Marcus; Charlotte E Lee; Juli E Jones; Amy E Deysher; Amanda R Waxman; Ryan D White; Todd D Williams; Jennifer L Lachey; Randy J Seeley; Bradford B Lowell; Joel K Elmquist
Journal:  J Clin Invest       Date:  2005-12       Impact factor: 14.808

8.  Expression of ghrelin receptor mRNA in the rat and the mouse brain.

Authors:  Jeffrey M Zigman; Juli E Jones; Charlotte E Lee; Clifford B Saper; Joel K Elmquist
Journal:  J Comp Neurol       Date:  2006-01-20       Impact factor: 3.215

9.  Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention.

Authors:  Jeffrey S Davies; Pia Kotokorpi; Sinan R Eccles; Sarah K Barnes; Pawel F Tokarczuk; Sophie K Allen; Hilary S Whitworth; Irina A Guschina; Bronwen A J Evans; Agneta Mode; Jeffrey M Zigman; Timothy Wells
Journal:  Mol Endocrinol       Date:  2009-03-19

10.  Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer.

Authors:  Steffen Helmling; Christian Maasch; Dirk Eulberg; Klaus Buchner; Werner Schröder; Christian Lange; Stefan Vonhoff; Britta Wlotzka; Matthias H Tschöp; Stefan Rosewicz; Sven Klussmann
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-25       Impact factor: 11.205
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