Literature DB >> 7679310

Injection of anti-neuropeptide Y gamma-globulin into the hypothalamic paraventricular nucleus decreases food intake in rats.

T Shibasaki1, T Oda, T Imaki, N Ling, H Demura.   

Abstract

The effect of immunoneutralization of hypothalamic neuropeptide Y (NPY) on food intake was examined to clarify the involvement of NPY in the control mechanism of feeding behavior. Injection of anti-NPY gamma-globulin into the bilateral hypothalamic paraventricular nuclei of 24-h food-deprived rats significantly inhibited food intake for 1 h after the injection compared with rats that received normal rabbit gamma-globulin. This result suggests that NPY in the paraventricular nucleus plays a role in stimulating feeding behavior.

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Year:  1993        PMID： 7679310     DOI： 10.1016/0006-8993(93)91727-a

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  10 in total

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Review 9.  Developmental programming of hypothalamic neuronal circuits: impact on energy balance control.

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  10 in total

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