Literature DB >> 1191262

The effect of some amine oxides and disulphide compounds on the activity of acetylcholinesterase.

R M Dawson.   

Abstract

Three amine oxides, two aliphatic and one aromatic, and 2,2'-dithiodipyridine were found to be weak reversible inhibitors of acetylcholinesterase. 5,5'-Dithiobis-(2-nitro-benzoic acid) had no effect on the enzyme under the conditions of the Ellman spectrophotometric assay.

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 1191262      PMCID： PMC1165617          DOI： 10.1042/bj1490293

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

1.  Affinity chromatography of triton-solubilized brain acetylcholinesterase.

Authors:  R M Dawson; H D Crone
Journal:  J Chromatogr       Date:  1974-05-22

2.  The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters.

Authors:  R Eisenthal; A Cornish-Bowden
Journal:  Biochem J       Date:  1974-06       Impact factor: 3.857

Review 3.  The pharmacology and biochemistry of N-oxides.

Authors:  M H Bickel
Journal:  Pharmacol Rev       Date:  1969-12       Impact factor: 25.468

4.  Studies of catalysis by acetylcholinesterase. Synergistic effects of inhibitors during the hydrolysis of acetic acid esters.

Authors:  T L Rosenberry; S A Bernhard
Journal:  Biochemistry       Date:  1972-11-07       Impact factor: 3.162

5.  An improved preparation of tertiary amine N-oxides.

Authors:  J Cymerman Craig; K K Purushothaman
Journal:  J Org Chem       Date:  1970-05       Impact factor: 4.354

6.  Amine oxide analogs of certain cholinergic agents.

Authors:  Joseph G Cannon; Robert V Smith; Glenn A Fischer; John P Long; Frederick W Benz
Journal:  J Med Chem       Date:  1971-01       Impact factor: 7.446

7.  The modification of cholinesterase activity by 5,5'-dithiobis-(2-nitrobenzoic acid) included in the coupled spectrophotometric assay. Evidence for a non-catalytic substrate-binding site.

Authors:  C Brownson; D C Watts
Journal:  Biochem J       Date:  1973-02       Impact factor: 3.857

8.  The effects of two disulphides on cholinesterase activity in the spectrophotometric assay.

Authors:  K B Augustinsson; H Eriksson
Journal:  Biochem J       Date:  1974-04       Impact factor: 3.857

9.  Kinetics of the reversible reaction of papain with 5,5'-dithiobis-(2-nitrobenzoate) dianion: evidence for nucleophilic reactivity in the un-ionized thiol group of cysteine-25 and for general acid catalysis by histidine-159 of the reaction of the 5-mercapto-2-nitrobenzoate dianion with the papain-5-mercapto-2-nitrobenzoate mixed disulphide.

Authors:  G Little; K Brocklehurst
Journal:  Biochem J       Date:  1972-06       Impact factor: 3.857

10.  Reactivities of the various protonic states in the reactions of papain and of L-cysteine with 2,2'- and with 4,4'- dipyridyl disulphide: evidence for nucleophilic reactivity in the un-ionized thiol group of the cysteine-25 residue of papain occasioned by its interaction with the histidine-159-asparagine-175 hydrogen-bonded system.

Authors:  K Brocklehurst; G Little
Journal:  Biochem J       Date:  1972-06       Impact factor: 3.857
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.