Literature DB >> 11888874

Analysis of nipple/areolar involvement with mastectomy: can the areola be preserved?

Rache M Simmons1, Meghan Brennan, Paul Christos, Valencia King, Michael Osborne.   

Abstract

BACKGROUND: Skin-sparing mastectomy (SSM), which involves the resection of the nipple/areolar complex with the breast parenchyma, improves the aesthetic outcome for breast cancer patients. Most patients undergoing SSM desire reconstruction of the nipple/areolar complex for symmetry. These data explore the possibility of preserving the areola in selected mastectomy patients.
METHODS: A retrospective analysis of 217 mastectomy patients was conducted to determine the frequency of malignant nipple and/or areola involvement. The association between nipple and/or areola involvement and prognostic factors, including tumor size, stage, nuclear grade, axillary nodal status, and tumor location, was evaluated.
RESULTS: The overall frequency of malignant nipple involvement was 23 of 217 (10.6%). In a subgroup of patients with tumors <2 cm, peripheral tumors, and with two positive nodes or less, the incidence of nipple involvement was 6.7%. When the nipple and areolar involvement were analyzed separately, only 2 of 217 patients had involvement of the areola (0.9%). All patients with areolar involvement had stage 3 breast cancer and were located centrally in the breast.
CONCLUSIONS: We conclude from these data that nipple preservation is not a reasonable option for mastectomy patients. However, preservation of the areola with mastectomy in selected patients warrants further study.

Entities:  

Mesh:

Year:  2002        PMID: 11888874     DOI: 10.1007/bf02557369

Source DB:  PubMed          Journal:  Ann Surg Oncol        ISSN: 1068-9265            Impact factor:   5.344


  44 in total

Review 1.  What is the evidence behind conservative mastectomies?

Authors:  Nicola Rocco; Giuseppe Catanuto; Maurizio Bruno Nava
Journal:  Gland Surg       Date:  2015-12

2.  Nipple-Sparing Mastectomy - Extended Indications and Limitations.

Authors:  Markus Niemeyera; Johannes Ettla; Birgit Plattnera; Rainer Schmida; Daniel Müllerb; Hans-Günther Machensb; Marion Kiechlea; Stefan Paepkea
Journal:  Breast Care (Basel)       Date:  2010-08-06       Impact factor: 2.860

Review 3.  Breast reconstruction: current and future options.

Authors:  Henry Paul; Tahira I Prendergast; Bryson Nicholson; Shenita White; Wayne Ai Frederick
Journal:  Breast Cancer (Dove Med Press)       Date:  2011-08-17

4.  Long-term follow-up of nipple-sparing mastectomy without radiotherapy: a single center study at a Japanese institution.

Authors:  Teruhisa Sakurai; Ning Zhang; Takaomi Suzuma; Teiji Umemura; Goro Yoshimura; Takeo Sakurai; Qifeng Yang
Journal:  Med Oncol       Date:  2013-02-02       Impact factor: 3.064

Review 5.  Immediate nipple-areola-sparing mastectomy reconstruction: An update on oncological and reconstruction techniques.

Authors:  Alexandre Mendonça Munhoz; Eduardo Montag; José Roberto Filassi; Rolf Gemperli
Journal:  World J Clin Oncol       Date:  2014-08-10

6.  The accuracy of intraoperative subareolar frozen section in nipple-sparing mastectomies.

Authors:  Daniel Luo; Jennifer Ha; Bruce Latham; David Ingram; Tony Connell; Diana Hastrich; Weng-Chan Yeow; Peter Willsher; Joseph Luo
Journal:  Ochsner J       Date:  2010

7.  Skin-sparing mastectomy with conservation of the nipple-areola complex and autologous reconstruction is an oncologically safe procedure.

Authors:  Bernd Gerber; Annette Krause; Toralf Reimer; Heiner Müller; Ingrid Küchenmeister; Joseph Makovitzky; Günther Kundt; Klaus Friese
Journal:  Ann Surg       Date:  2003-07       Impact factor: 12.969

8.  Feasibility of Nipple-Sparing Mastectomy with Immediate Breast Reconstruction in Breast Cancer Patients with Tumor-Nipple Distance Less Than 2.0 cm.

Authors:  Jai Min Ryu; Seok Jin Nam; Seok Won Kim; Se Kyung Lee; Soo Youn Bae; Ha Woo Yi; Sungmin Park; Hyun-June Paik; Jeong Eon Lee
Journal:  World J Surg       Date:  2016-08       Impact factor: 3.352

9.  Oncological outcome and patient satisfaction with skin-sparing mastectomy and immediate breast reconstruction: a prospective observational study.

Authors:  Sara Reefy; Neill Patani; Anne Anderson; Gwyne Burgoyne; Hisham Osman; Kefah Mokbel
Journal:  BMC Cancer       Date:  2010-04-29       Impact factor: 4.430

10.  Nipple Preservation in Breast Cancer Associated with Nipple Discharge.

Authors:  Rita Y K Chang; Polly S Y Cheung
Journal:  World J Surg       Date:  2017-01       Impact factor: 3.352

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