Literature DB >> 11879637

Conserved organization of centromeric chromatin in flies and humans.

Michael D Blower1, Beth A Sullivan, Gary H Karpen.   

Abstract

Recent studies have highlighted the importance of centromere-specific histone H3-like (CENP-A) proteins in centromere function. We show that Drosophila CID and human CENP-A appear at metaphase as a three-dimensional structure that lacks histone H3. However, blocks of CID/CENP-A and H3 nucleosomes are linearly interspersed on extended chromatin fibers, and CID is close to H3 nucleosomes in polynucleosomal preparations. When CID is depleted by RNAi, it is replaced by H3, demonstrating flexibility of centromeric chromatin organization. Finally, contrary to models proposing that H3 and CID/CENP-A nucleosomes are replicated at different times in S phase, we show that interspersed H3 and CID/CENP-A chromatin are replicated concurrently during S phase in humans and flies. We propose that the unique structural arrangement of CID/CENP-A and H3 nucleosomes presents centromeric chromatin to the poleward face of the condensing mitotic chromosome.

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Year:  2002        PMID： 11879637      PMCID： PMC3192492          DOI： 10.1016/s1534-5807(02)00135-1

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  56 in total

1.  CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate.

Authors:  H Saitoh; J Tomkiel; C A Cooke; H Ratrie; M Maurer; N F Rothfield; W C Earnshaw
Journal:  Cell       Date:  1992-07-10       Impact factor: 41.582

2.  Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone.

Authors:  D K Palmer; K O'Day; H L Trong; H Charbonneau; R L Margolis
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-01       Impact factor: 11.205

3.  Characterization of nucleosome core particles containing histone proteins made in bacteria.

Authors:  K Luger; T J Rechsteiner; A J Flaus; M M Waye; T J Richmond
Journal:  J Mol Biol       Date:  1997-09-26       Impact factor: 5.469

4.  A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA.

Authors:  D du Sart; M R Cancilla; E Earle; J I Mao; R Saffery; K M Tainton; P Kalitsis; J Martyn; A E Barry; K H Choo
Journal:  Nat Genet       Date:  1997-06       Impact factor: 38.330

5.  Formation of de novo centromeres and construction of first-generation human artificial microchromosomes.

Authors:  J J Harrington; G Van Bokkelen; R W Mays; K Gustashaw; H F Willard
Journal:  Nat Genet       Date:  1997-04       Impact factor: 38.330

6.  Structural analysis of alpha-satellite DNA and centromere proteins using extended chromatin and chromosomes.

Authors:  T Haaf; D C Ward
Journal:  Hum Mol Genet       Date:  1994-05       Impact factor: 6.150

7.  Identification of centromeric antigens in dicentric Robertsonian translocations: CENP-C and CENP-E are necessary components of functional centromeres.

Authors:  B A Sullivan; S Schwartz
Journal:  Hum Mol Genet       Date:  1995-12       Impact factor: 6.150

Review 8.  Unusual kinetochores and chromatin diminution in Parascaris.

Authors:  S Pimpinelli; C Goday
Journal:  Trends Genet       Date:  1989-09       Impact factor: 11.639

9.  The centromere-kinetochore complex: a repeat subunit model.

Authors:  R P Zinkowski; J Meyne; B R Brinkley
Journal:  J Cell Biol       Date:  1991-06       Impact factor: 10.539

10.  Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites.

Authors:  R D Shelby; O Vafa; K F Sullivan
Journal:  J Cell Biol       Date:  1997-02-10       Impact factor: 10.539
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  272 in total

1.  Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis.

Authors:  Ana Losada; Michiko Hirano; Tatsuya Hirano
Journal:  Genes Dev       Date:  2002-12-01       Impact factor: 11.361

2.  CaMtw1, a member of the evolutionarily conserved Mis12 kinetochore protein family, is required for efficient inner kinetochore assembly in the pathogenic yeast Candida albicans.

Authors:  Babhrubahan Roy; Laura S Burrack; Museer A Lone; Judith Berman; Kaustuv Sanyal
Journal:  Mol Microbiol       Date:  2011-02-10       Impact factor: 3.501

Review 3.  Breaking Symmetry - Asymmetric Histone Inheritance in Stem Cells.

Authors:  Jing Xie; Matthew Wooten; Vuong Tran; Xin Chen
Journal:  Trends Cell Biol       Date:  2017-03-06       Impact factor: 20.808

4.  Partitioning of the maize epigenome by the number of methyl groups on histone H3 lysines 9 and 27.

Authors:  Jinghua Shi; R Kelly Dawe
Journal:  Genetics       Date:  2006-04-19       Impact factor: 4.562

5.  Sequence analysis of a functional Drosophila centromere.

Authors:  Xiaoping Sun; Hiep D Le; Janice M Wahlstrom; Gary H Karpen
Journal:  Genome Res       Date:  2003-02       Impact factor: 9.043

6.  Co-localization of centromere activity, proteins and topoisomerase II within a subdomain of the major human X alpha-satellite array.

Authors:  Jennifer M Spence; Ricky Critcher; Thomas A Ebersole; Manuel M Valdivia; William C Earnshaw; Tatsuo Fukagawa; Christine J Farr
Journal:  EMBO J       Date:  2002-10-01       Impact factor: 11.598

Review 7.  Histone H3 variants specify modes of chromatin assembly.

Authors:  Kami Ahmad; Steven Henikoff
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-12       Impact factor: 11.205

8.  The small chromosomes of Trypanosoma brucei involved in antigenic variation are constructed around repetitive palindromes.

Authors:  Bill Wickstead; Klaus Ersfeld; Keith Gull
Journal:  Genome Res       Date:  2004-06       Impact factor: 9.043

9.  Localisation of centromeric proteins to a fraction of mouse minor satellite DNA on a mini-chromosome in human, mouse and chicken cells.

Authors:  Kang Zeng; Jose I de las Heras; Andrew Ross; Jian Yang; Howard Cooke; Ming Hong Shen
Journal:  Chromosoma       Date:  2004-07-28       Impact factor: 4.316

Review 10.  Centromeres, kinetochores and the segregation of chromosomes. Foreword.

Authors:  Christine J Farr
Journal:  Chromosome Res       Date:  2004       Impact factor: 5.239
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