| Literature DB >> 9171825 |
D du Sart1, M R Cancilla, E Earle, J I Mao, R Saffery, K M Tainton, P Kalitsis, J Martyn, A E Barry, K H Choo.
Abstract
We recently described a human marker chromosome containing a functional neo-centromere that binds anti-centromere antibodies, but is devoid of centromeric alpha-satellite repeats and derived from a hitherto non-centromeric region of chromosome 10q25. Chromosome walking using cloned single-copy DNA from this region enabled us to identify the antibody-binding domain of this centromere. Extensive restriction mapping indicates that this domain has an identical genomic organization to the corresponding normal chromosomal region, suggesting a mechanism for the origin of this centromere through the activation of a latent centromere that exists within 10q25.Entities:
Mesh：
Substances：
Year: 1997 PMID： 9171825 DOI： 10.1038/ng0697-144
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330