Literature DB >> 1184689

Automated high-resolution gas chromatographic system for recording and evaluation of metabolic profiles.

M L McConnell, M Novotný.   

Abstract

A fully automated high-resolution gas chromatographic system is described that incorporates repetitive sampling of volatile biological samples onto a glass capillary column, and a simultaneous flame ionization and nitrogen-sensitive detection prior to data acquisition and computer handling. Reliable headspace sampling procedure and reproducible column characteristics that are essential to automation have been studied. The application of this system to the reproducible chromatographic recording of human urinary volatile constituents is shown.

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Year:  1975        PMID: 1184689     DOI: 10.1016/s0021-9673(00)99985-0

Source DB:  PubMed          Journal:  J Chromatogr


  3 in total

1.  High Resolution Separations and Improved Ion Production and Transmission in Metabolomics.

Authors:  Thomas O Metz; Jason S Page; Erin S Baker; Keqi Tang; Jie Ding; Yufeng Shen; Richard D Smith
Journal:  Trends Analyt Chem       Date:  2008-03       Impact factor: 12.296

2.  The future of liquid chromatography-mass spectrometry (LC-MS) in metabolic profiling and metabolomic studies for biomarker discovery.

Authors:  Thomas O Metz; Qibin Zhang; Jason S Page; Yufeng Shen; Stephen J Callister; Jon M Jacobs; Richard D Smith
Journal:  Biomark Med       Date:  2007-06       Impact factor: 2.851

3.  Structural relationships between the endogenous volatile urinary metabolites of experimentally diabetic rats and certain neurotoxins (l).

Authors:  G Rhodes; M L Holland; D Wiesler; M Novotny; S A Moore; R G Peterson; D L Felten
Journal:  Experientia       Date:  1982-01-15
  3 in total

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