Literature DB >> 7056362

Structural relationships between the endogenous volatile urinary metabolites of experimentally diabetic rats and certain neurotoxins (l).

G Rhodes, M L Holland, D Wiesler, M Novotny, S A Moore, R G Peterson, D L Felten.   

Abstract

High resolution glass capillary gas chromatography and GC/MS were utilized to examine qualitative and quantitative variations from normal of urinary volatile metabolites of long-term alloxan and streptozotocin diabetic rats. Volatile metabolites were structurally compared with known neurotoxins to examine any possible relationship between these metabolites and the development of the diabetic polyneuropathy.

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Year:  1982        PMID： 7056362     DOI： 10.1007/bf01944536

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

1.  Automated high-resolution gas chromatographic system for recording and evaluation of metabolic profiles.

Authors:  M L McConnell; M Novotný
Journal:  J Chromatogr       Date:  1975-10-29

2.  Degeneration in central and peripheral nervous systems produced by pure n-hexane: an experimental study.

Authors:  H H Schaumburg; P S Spencer
Journal:  Brain       Date:  1976-06       Impact factor: 13.501

3.  Axonal dysfunction in the neuropathy of diabetes mellitus: a quantitative electrophysiological study.

Authors:  S Hansen; J P Ballantyne
Journal:  J Neurol Neurosurg Psychiatry       Date:  1977-06       Impact factor: 10.154

Review 4.  Diabetic neuropathy--new concepts of its etiology.

Authors:  R S Clements
Journal:  Diabetes       Date:  1979-06       Impact factor: 9.461

5.  Peripheral nerve structure and function in experimental diabetes.

Authors:  A K Sharma; P K Thomas
Journal:  J Neurol Sci       Date:  1974-09       Impact factor: 3.181

6.  On the specific molecular configuration of neurotoxic aliphatic hexacarbon compounds causing central--peripheral distal axonopathy.

Authors:  P S Spencer; M C Bischoff; H H Schaumburg
Journal:  Toxicol Appl Pharmacol       Date:  1978-04       Impact factor: 4.219

7.  Experimental neuropathy produced by 2,5-hexanedione--a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone.

Authors:  P S Spencer; H H Schaumburg
Journal:  J Neurol Neurosurg Psychiatry       Date:  1975-08       Impact factor: 10.154

8.  Gas chromatographic-mass spectrometric study of volatile organic metabolites in urines of patients with diabetes mellitus.

Authors:  H M Liebich; O Al-Babbili
Journal:  J Chromatogr       Date:  1975-10-29

9.  Does a defect of energy metabolism in the nerve fiber underlie axonal degeneration in polyneuropathies?

Authors:  P S Spencer; M I Sabri; H H Schaumburg; C L Moore
Journal:  Ann Neurol       Date:  1979-06       Impact factor: 10.422

10.  Axonal dwindling in early experimental diabetes. II. A study of isolated nerve fibres.

Authors:  J Jakobsen
Journal:  Diabetologia       Date:  1976-12       Impact factor: 10.122
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  1 in total

Review 1.  Biochemical individuality reflected in chromatographic, electrophoretic and mass-spectrometric profiles.

Authors:  Milos V Novotny; Helena A Soini; Yehia Mechref
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2008-04-15       Impact factor: 3.205
  1 in total

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