OBJECTIVE: To evaluate the efficacy of blastocyst culture and transfer in human in vitro fertilization (IVF) as compared to day 3 embryo transfer. DESIGN: Prospective randomized trial. SETTING: Private assisted reproduction unit. PATIENT(S): A total of 162 IVF patients were included in the day 3 embryo transfer (n = 82) and blastocyst transfer (n = 80) groups. INTERVENTION(S): Embryo transfer on day 3 after culture in the standard culture media and blastocyst transfer on day 5 or 6 after culture in the sequential culture media. MAIN OUTCOME MEASURE(S): Implantation and pregnancy rates, multiple gestation rate. RESULT(S): The implantation rate for embryos transferred at the blastocyst stage was significantly higher than that for embryos transferred on day 3 (26% vs. 13%). The viable pregnancy rate was similar in both groups (29% vs. 26%). Significantly fewer embryos were required for transfer at the blastocyst stage compared with day 3 embryo transfer (2.0 +/- 0.1 vs. 3.5 +/- 0.63). The high-order multiple gestation rate was significantly less with the blastocyst transfer than with the day 3 embryo transfer (4% vs. 19%). CONCLUSION(S): With the use of blastocyst culture, a few embryos can be transferred without decreasing the overall pregnancy rate. This may reduce multiple gestations and improve human IVF outcome.
RCT Entities:
OBJECTIVE: To evaluate the efficacy of blastocyst culture and transfer in human in vitro fertilization (IVF) as compared to day 3 embryo transfer. DESIGN: Prospective randomized trial. SETTING: Private assisted reproduction unit. PATIENT(S): A total of 162 IVFpatients were included in the day 3 embryo transfer (n = 82) and blastocyst transfer (n = 80) groups. INTERVENTION(S): Embryo transfer on day 3 after culture in the standard culture media and blastocyst transfer on day 5 or 6 after culture in the sequential culture media. MAIN OUTCOME MEASURE(S): Implantation and pregnancy rates, multiple gestation rate. RESULT(S): The implantation rate for embryos transferred at the blastocyst stage was significantly higher than that for embryos transferred on day 3 (26% vs. 13%). The viable pregnancy rate was similar in both groups (29% vs. 26%). Significantly fewer embryos were required for transfer at the blastocyst stage compared with day 3 embryo transfer (2.0 +/- 0.1 vs. 3.5 +/- 0.63). The high-order multiple gestation rate was significantly less with the blastocyst transfer than with the day 3 embryo transfer (4% vs. 19%). CONCLUSION(S): With the use of blastocyst culture, a few embryos can be transferred without decreasing the overall pregnancy rate. This may reduce multiple gestations and improve humanIVF outcome.
Authors: Stephanie J Estes; Linda M Hoover; Scott E Smith; Stephen G Somkuti; Jay S Schinfeld; Larry I Barmat Journal: J Assist Reprod Genet Date: 2003-10 Impact factor: 3.412
Authors: Kate Devine; Sunni L Mumford; Mae Wu; Alan H DeCherney; Micah J Hill; Anthony Propst Journal: Fertil Steril Date: 2015-06-11 Impact factor: 7.329
Authors: B Almog; I Levin; I Wagman; R Kapustiansky; T Schwartz; N Mey-Raz; A Amit; F Azem Journal: J Assist Reprod Genet Date: 2008-08-14 Impact factor: 3.412
Authors: Eric D Levens; Brian W Whitcomb; Sasha Hennessy; Aidita N James; Belinda J Yauger; Frederick W Larsen Journal: Fertil Steril Date: 2008-01-07 Impact factor: 7.329