Literature DB >> 11729305

Hedgehog signaling: a tale of two lipids.

P W Ingham1.   

Abstract

Hedgehog proteins constitute one of the major classes of intercellular signals that control inductive interactions during animal development. These proteins undergo unusual lipid modifications and signal through an unconventional transmembrane protein receptor that is characterized by a sequence motif implicated in sterol sensing. Recent studies suggest that the lipid adducts regulate the range and potency of the signals, whereas the sterol-sensing domain is essential for receptor activity.

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Year:  2001        PMID： 11729305     DOI： 10.1126/science.1064115

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  14 in total

1.  From gallstones to genes: two hundred years of sterol research. A tribute to George J. Schroepfer Jr.

Authors:  Geoffrey F Gibbons
Journal:  Lipids       Date:  2002-12       Impact factor: 1.880

Review 2.  Cholesterol modification of Hedgehog family proteins.

Authors:  Juhee Jeong; Andrew P McMahon
Journal:  J Clin Invest       Date:  2002-09       Impact factor: 14.808

Review 3.  Malformation syndromes due to inborn errors of cholesterol synthesis.

Authors:  Forbes D Porter
Journal:  J Clin Invest       Date:  2002-09       Impact factor: 14.808

Review 4.  Genetic and epigenetic mechanisms in the early development of the vascular system.

Authors:  Domenico Ribatti
Journal:  J Anat       Date:  2006-02       Impact factor: 2.610

5.  GLI1, CTNNB1 and NOTCH1 protein expression in a thymic epithelial malignancy tissue microarray.

Authors:  Jonathan W Riess; Robert West; Michelle Dean; Alex C Klimowicz; Joel W Neal; Chuong Hoang; Heather A Wakelee
Journal:  Anticancer Res       Date:  2015-02       Impact factor: 2.480

6.  SHH E176/E177-Zn2+ conformation is required for signaling at endogenous sites.

Authors:  Diana S Himmelstein; Ivelisse Cajigas; Chunming Bi; Brian S Clark; Grant Van Der Voort; Jhumku D Kohtz
Journal:  Dev Biol       Date:  2017-03-02       Impact factor: 3.582

7.  DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism.

Authors:  Martina Zikova; Alicia Corlett; Zdenka Bendova; Petr Pajer; Petr Bartunek
Journal:  Mol Endocrinol       Date:  2009-01-29

8.  Defective TGF-β signaling in bone marrow-derived cells prevents hedgehog-induced skin tumors.

Authors:  Qipeng Fan; Dongsheng Gu; Hailan Liu; Ling Yang; Xiaoli Zhang; Mervin C Yoder; Mark H Kaplan; Jingwu Xie
Journal:  Cancer Res       Date:  2013-11-26       Impact factor: 12.701

Review 9.  Role of perlecan in skeletal development and diseases.

Authors:  John Hassell; Yoshihiko Yamada; Eri Arikawa-Hirasawa
Journal:  Glycoconj J       Date:  2002 May-Jun       Impact factor: 2.916

Review 10.  Molecular pathology and genetics of congenital hepatorenal fibrocystic syndromes.

Authors:  C A Johnson; P Gissen; C Sergi
Journal:  J Med Genet       Date:  2003-05       Impact factor: 6.318
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