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Literature DB >> 12208857

Cholesterol modification of Hedgehog family proteins.

Juhee Jeong¹, Andrew P McMahon.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2002 PMID： 12208857 PMCID： PMC151115 DOI： 10.1172/JCI16506

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

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57 in total

Review 1. The Hedgehog and Wnt signalling pathways in cancer.

Authors: J Taipale; P A Beachy
Journal: Nature Date: 2001-05-17 Impact factor: 49.962

Review 2. Multiple roles of cholesterol in hedgehog protein biogenesis and signaling.

Authors: P A Beachy; M K Cooper; K E Young; D P von Kessler; W J Park; T M Hall; D J Leahy; J A Porter
Journal: Cold Spring Harb Symp Quant Biol Date: 1997

3. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells.

Authors: R Burke; D Nellen; M Bellotto; E Hafen; K A Senti; B J Dickson; K Basler
Journal: Cell Date: 1999-12-23 Impact factor: 41.582

4. Dual roles for patched in sequestering and transducing Hedgehog.

Authors: Y Chen; G Struhl
Journal: Cell Date: 1996-11-01 Impact factor: 41.582

5. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1.

Authors: P M Lewis; M P Dunn; J A McMahon; M Logan; J F Martin; B St-Jacques; A P McMahon
Journal: Cell Date: 2001-06-01 Impact factor: 41.582

6. Enhanced potency of human Sonic hedgehog by hydrophobic modification.

Authors: F R Taylor; D Wen; E A Garber; A N Carmillo; D P Baker; R M Arduini; K P Williams; P H Weinreb; P Rayhorn; X Hronowski; A Whitty; E S Day; A Boriack-Sjodin; R I Shapiro; A Galdes; R B Pepinsky
Journal: Biochemistry Date: 2001-04-10 Impact factor: 3.162

Cholesterol modification of Hedgehog family proteins.

Review 1. The Hedgehog and Wnt signalling pathways in cancer.

Review 2. Multiple roles of cholesterol in hedgehog protein biogenesis and signaling.

3. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells.

4. Dual roles for patched in sequestering and transducing Hedgehog.

5. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1.

6. Enhanced potency of human Sonic hedgehog by hydrophobic modification.

7. Proteolytic processing yields two secreted forms of sonic hedgehog.

8. Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling.

9. Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing.

10. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.

Review 1. Cholesterol, lipid rafts, and disease.

Review 2. Malformation syndromes due to inborn errors of cholesterol synthesis.

3. Intramolecular disulfide bond between catalytic cysteines in an intein precursor.

Review 4. Dynamic signaling for neural stem cell fate determination.

Review 5. New paradigms in the establishment and maintenance of gradients during directed cell migration.

6. The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans.

Review 7. Developmental and extrahepatic physiological functions of SREBP pathway genes in mice.

8. Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein Kinase.

Review 9. Regulation of Hedgehog signaling: a complex story.

10. Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse.