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Literature DB >> 12975604

Role of perlecan in skeletal development and diseases.

John Hassell¹, Yoshihiko Yamada, Eri Arikawa-Hirasawa.

Abstract

Perlecan, a large heparan sulfate proteoglycan (HSPG), is present in the basement membrane and other extracellular matrices. Its protein core is 400 kDa in size and consists of five distinct structural domains. A number of in vitro studies suggest multiple functions of perlecan in cell growth and differentiation and tissue organization. Recent studies with gene knockout mice and human diseases revealed critical in vivo roles of perlecan in cartilage development and neuromuscular junction activity.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2002 PMID： 12975604 DOI： 10.1023/A:1025340215261

Source DB: PubMed Journal: Glycoconj J ISSN： 0282-0080 Impact factor: 2.916

64 in total

Review 1. UNC-52/perlecan isoform diversity and function in Caenorhabditis elegans.

Authors: T M Rogalski; G P Mullen; J A Bush; E J Gilchrist; D G Moerman
Journal: Biochem Soc Trans Date: 2001-05 Impact factor: 5.407

2. Structural and functional characterization of the human perlecan gene promoter. Transcriptional activation by transforming growth factor-beta via a nuclear factor 1-binding element.

Authors: R V Iozzo; J Pillarisetti; B Sharma; A D Murdoch; K G Danielson; J Uitto; A Mauviel
Journal: J Biol Chem Date: 1997-02-21 Impact factor: 5.157

3. Isolation of a heparan sulfate-containing proteoglycan from basement membrane.

Authors: J R Hassell; P G Robey; H J Barrach; J Wilczek; S I Rennard; G R Martin
Journal: Proc Natl Acad Sci U S A Date: 1980-08 Impact factor: 11.205

4. The C-terminal domain V of perlecan promotes beta1 integrin-mediated cell adhesion, binds heparin, nidogen and fibulin-2 and can be modified by glycosaminoglycans.

Authors: J C Brown; T Sasaki; W Göhring; Y Yamada; R Timpl
Journal: Eur J Biochem Date: 1997-11-15

5. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1.

Authors: P M Lewis; M P Dunn; J A McMahon; M Logan; J F Martin; B St-Jacques; A P McMahon
Journal: Cell Date: 2001-06-01 Impact factor: 41.582

6. Amino acid determinants that drive heparan sulfate assembly in a proteoglycan.

Authors: L Zhang; J D Esko
Journal: J Biol Chem Date: 1994-07-29 Impact factor: 5.157

7. The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases.

Authors: J M Whitelock; A D Murdoch; R V Iozzo; P A Underwood
Journal: J Biol Chem Date: 1996-04-26 Impact factor: 5.157

8. Mechanisms of chain initiation in the biosynthesis of connective tissue polysaccharides.

Authors: L Rodén; T Koerner; C Olson; N B Schwartz
Journal: Fed Proc Date: 1985-02

9. Acetylcholinesterase clustering at the neuromuscular junction involves perlecan and dystroglycan.

Authors: H B Peng; H Xie; S G Rossi; R L Rotundo
Journal: J Cell Biol Date: 1999-05-17 Impact factor: 10.539

10. Perlecan maintains the integrity of cartilage and some basement membranes.

Authors: M Costell; E Gustafsson; A Aszódi; M Mörgelin; W Bloch; E Hunziker; K Addicks; R Timpl; R Fässler
Journal: J Cell Biol Date: 1999-11-29 Impact factor: 10.539

25 in total

1. Comparative spatial and temporal localisation of perlecan, aggrecan and type I, II and IV collagen in the ovine meniscus: an ageing study.

Authors: James Melrose; Susan Smith; Martin Cake; Richard Read; John Whitelock
Journal: Histochem Cell Biol Date: 2005-10-28 Impact factor: 4.304

Review 2. Endostatin and endorepellin: A common route of action for similar angiostatic cancer avengers.

Authors: Chiara Poluzzi; Renato V Iozzo; Liliana Schaefer
Journal: Adv Drug Deliv Rev Date: 2015-10-27 Impact factor: 15.470

3. Spatiotemporal distribution of heparan sulfate epitopes during murine cartilage growth plate development.

Authors: Ronald R Gomes; Toin H Van Kuppevelt; Mary C Farach-Carson; Daniel D Carson
Journal: Histochem Cell Biol Date: 2006-07-12 Impact factor: 4.304

4. Chondrogenic differentiation on perlecan domain I, collagen II, and bone morphogenetic protein-2-based matrices.

Authors: Weidong Yang; Ronald R Gomes; Anissa J Brown; Ashley R Burdett; Michael Alicknavitch; Mary C Farach-Carson; Daniel D Carson
Journal: Tissue Eng Date: 2006-07

Review 5. Border patrol: insights into the unique role of perlecan/heparan sulfate proteoglycan 2 at cell and tissue borders.

Authors: Mary C Farach-Carson; Curtis R Warren; Daniel A Harrington; Daniel D Carson
Journal: Matrix Biol Date: 2013-08-31 Impact factor: 11.583