| Literature DB >> 11571351 |
A L DeStefano1, L I Golbe, M H Mark, A M Lazzarini, N E Maher, M Saint-Hilaire, R G Feldman, M Guttman, R L Watts, O Suchowersky, A L Lafontaine, N Labelle, M F Lew, C H Waters, J H Growdon, C Singer, L J Currie, G F Wooten, P Vieregge, P P Pramstaller, C Klein, J P Hubble, M Stacy, E Montgomery, M E MacDonald, J F Gusella, R H Myers.
Abstract
A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine beta-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11571351 DOI： 10.1212/wnl.57.6.1124
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910