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Literature DB >> 12169225

The genetics of Parkinson's disease.

Kah Leong Lim¹, Valina L Dawson, Ted M Dawson.

Abstract

The recent identification of several genes and gene loci linked to familial forms of Parkinson's disease (PD) has contributed significantly to our understanding of the genetic contribution in PD. Although the etiology of sporadic PD remains unknown, it is currently assumed that genetic susceptibilities may be involved. The advent of genome-wide scanning techniques has now made it possible to conduct complete genome screens for linkage in PD in multigenerational parkinsonian kindreds. Such studies undoubtedly will be instrumental in establishing the susceptibility genes involved in idiopathic PD. This article reviews the recent advances in the genetics of PD.

Entities: Disease

Mesh：

Substances：

Year: 2002 PMID： 12169225 DOI： 10.1007/s11910-002-0071-9

Source DB: PubMed Journal: Curr Neurol Neurosci Rep ISSN： 1528-4042 Impact factor: 5.081

46 in total

1. Identifying genetic factors in Parkinson disease.

Authors: Matt Farrer; John Hardy; Mike Hutton; Demetrius Maraganore; Yoshio Tsuboi; Zbigniew K Wszolek
Journal: JAMA Date: 2002-02-13 Impact factor: 56.272

2. The ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism does not confer protection against idiopathic Parkinson's disease.

Authors: G D Mellick; P A Silburn
Journal: Neurosci Lett Date: 2000-10-27 Impact factor: 3.046

3. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.

Authors: R Krüger; W Kuhn; T Müller; D Woitalla; M Graeber; S Kösel; H Przuntek; J T Epplen; L Schöls; O Riess
Journal: Nat Genet Date: 1998-02 Impact factor: 38.330

4. Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27.

Authors: H Matsumine; M Saito; S Shimoda-Matsubayashi; H Tanaka; A Ishikawa; Y Nakagawa-Hattori; M Yokochi; T Kobayashi; S Igarashi; H Takano; K Sanpei; R Koike; H Mori; T Kondo; Y Mizutani; A A Schäffer; Y Yamamura; S Nakamura; S Kuzuhara; S Tsuji; Y Mizuno
Journal: Am J Hum Genet Date: 1997-03 Impact factor: 11.025

5. Complete genomic screen in Parkinson disease: evidence for multiple genes.

Authors: W K Scott; M A Nance; R L Watts; J P Hubble; W C Koller; K Lyons; R Pahwa; M B Stern; A Colcher; B C Hiner; J Jankovic; W G Ondo; F H Allen; C G Goetz; G W Small; D Masterman; F Mastaglia; N G Laing; J M Stajich; B Slotterbeck; M W Booze; R C Ribble; E Rampersaud; S G West; R A Gibson; L T Middleton; A D Roses; J L Haines; B L Scott; J M Vance; M A Pericak-Vance
Journal: JAMA Date: 2001-11-14 Impact factor: 56.272

6. Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36.

Authors: C M van Duijn; M C Dekker; V Bonifati; R J Galjaard; J J Houwing-Duistermaat; P J Snijders; L Testers; G J Breedveld; M Horstink; L A Sandkuijl; J C van Swieten; B A Oostra; P Heutink
Journal: Am J Hum Genet Date: 2001-07-02 Impact factor: 11.025

7. Lewy bodies and parkinsonism in families with parkin mutations.

Authors: M Farrer; P Chan; R Chen; L Tan; S Lincoln; D Hernandez; L Forno; K Gwinn-Hardy; L Petrucelli; J Hussey; A Singleton; C Tanner; J Hardy; J W Langston
Journal: Ann Neurol Date: 2001-09 Impact factor: 10.422

8. Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease.

Authors: K K Chung; Y Zhang; K L Lim; Y Tanaka; H Huang; J Gao; C A Ross; V L Dawson; T M Dawson
Journal: Nat Med Date: 2001-10 Impact factor: 53.440

9. Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease.

Authors: D M Maraganore; M J Farrer; J A Hardy; S J Lincoln; S K McDonnell; W A Rocca
Journal: Neurology Date: 1999-11-10 Impact factor: 9.910

10. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase.

Authors: H Shimura; N Hattori; S i Kubo; Y Mizuno; S Asakawa; S Minoshima; N Shimizu; K Iwai; T Chiba; K Tanaka; T Suzuki
Journal: Nat Genet Date: 2000-07 Impact factor: 38.330

7 in total

Review 1. The role of parkin in familial and sporadic Parkinson's disease.

Authors: Ted M Dawson; Valina L Dawson
Journal: Mov Disord Date: 2010 Impact factor: 10.338

2. Differential expression of splice variant and wild-type parkin in sporadic Parkinson's disease.

Authors: E K Tan; H Shen; J M M Tan; K L Lim; S Fook-Chong; W P Hu; M C Paterson; V R Chandran; K Yew; C Tan; Y Yuen; R Pavanni; M C Wong; K Puvan; Y Zhao
Journal: Neurogenetics Date: 2005-08-06 Impact factor: 2.660

Review 3. The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system.

Authors: Eliseo A Eugenin; Daniel Basilio; Juan C Sáez; Juan A Orellana; Cedric S Raine; Feliksas Bukauskas; Michael V L Bennett; Joan W Berman
Journal: J Neuroimmune Pharmacol Date: 2012-03-23 Impact factor: 4.147

4. Loss of locus coeruleus neurons and reduced startle in parkin null mice.

Authors: Rainer Von Coelln; Bobby Thomas; Joseph M Savitt; Kah Leong Lim; Masayuki Sasaki; Ellen J Hess; Valina L Dawson; Ted M Dawson
Journal: Proc Natl Acad Sci U S A Date: 2004-07-12 Impact factor: 11.205

Review 5. Disturbance of iron metabolism as a contributing factor to SN hyperechogenicity in Parkinson's disease: implications for idiopathic and monogenetic forms.

Authors: Daniela Berg
Journal: Neurochem Res Date: 2007-04-28 Impact factor: 3.996

6. Biology of Parkinson's disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder.

Authors: Garrett E Alexander
Journal: Dialogues Clin Neurosci Date: 2004-09 Impact factor: 5.986

7. Neurofilamentopathy in neurodegenerative diseases.

Authors: Quan Liu; Fang Xie; Abdiel Alvarado-Diaz; Mark A Smith; Paula I Moreira; Xiongwei Zhu; George Perry
Journal: Open Neurol J Date: 2011-08-26

7 in total