Literature DB >> 16024878

Neurodegenerative disorders: Parkinson's disease and Huntington's disease.

S M Hague1, S Klaffke, O Bandmann.   

Abstract

Parkinson's disease and Huntington's disease are both model diseases. Parkinson's disease is the most common of several akinetic-rigid syndromes and Huntington's disease is only one of an ever growing number of trinucleotide repeat disorders. Molecular genetic studies and subsequent molecular biological studies have provided fascinating new insights into the pathogenesis of both disorders and there is now real hope for disease modifying treatment in the not too distant future for patients with Parkinson's disease or Huntington's disease.

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Year:  2005        PMID： 16024878      PMCID： PMC1739745          DOI： 10.1136/jnnp.2004.060186

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  70 in total

1.  Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation.

Authors:  P J Spira; D M Sharpe; G Halliday; J Cavanagh; G A Nicholson
Journal:  Ann Neurol       Date:  2001-03       Impact factor: 10.422

Review 2.  Loss of normal huntingtin function: new developments in Huntington's disease research.

Authors:  E Cattaneo; D Rigamonti; D Goffredo; C Zuccato; F Squitieri; S Sipione
Journal:  Trends Neurosci       Date:  2001-03       Impact factor: 13.837

3.  The ubiquitin pathway in Parkinson's disease.

Authors:  E Leroy; R Boyer; G Auburger; B Leube; G Ulm; E Mezey; G Harta; M J Brownstein; S Jonnalagada; T Chernova; A Dehejia; C Lavedan; T Gasser; P J Steinbach; K D Wilkinson; M H Polymeropoulos
Journal:  Nature       Date:  1998-10-01       Impact factor: 49.962

4.  Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.

Authors:  R Krüger; W Kuhn; T Müller; D Woitalla; M Graeber; S Kösel; H Przuntek; J T Epplen; L Schöls; O Riess
Journal:  Nat Genet       Date:  1998-02       Impact factor: 38.330

5.  Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.

Authors:  M H Polymeropoulos; C Lavedan; E Leroy; S E Ide; A Dehejia; A Dutra; B Pike; H Root; J Rubenstein; R Boyer; E S Stenroos; S Chandrasekharappa; A Athanassiadou; T Papapetropoulos; W G Johnson; A M Lazzarini; R C Duvoisin; G Di Iorio; L I Golbe; R L Nussbaum
Journal:  Science       Date:  1997-06-27       Impact factor: 47.728

6.  Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release.

Authors:  N R Jana; E A Zemskov; N Nukina
Journal:  Hum Mol Genet       Date:  2001-05-01       Impact factor: 6.150

Review 7.  Therapeutic opportunities in polyglutamine disease.

Authors:  R E Hughes; J M Olson
Journal:  Nat Med       Date:  2001-04       Impact factor: 53.440

8.  Clinical genetic analysis of Parkinson's disease in the Contursi kindred.

Authors:  L I Golbe; G Di Iorio; G Sanges; A M Lazzarini; S La Sala; V Bonavita; R C Duvoisin
Journal:  Ann Neurol       Date:  1996-11       Impact factor: 10.422

9.  Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein/apolipoprotein E genotype.

Authors:  R Krüger; A M Vieira-Saecker; W Kuhn; D Berg; T Müller; N Kühnl; G A Fuchs; A Storch; M Hungs; D Woitalla; H Przuntek; J T Epplen; L Schöls; O Riess
Journal:  Ann Neurol       Date:  1999-05       Impact factor: 10.422

10.  Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease.

Authors:  Coro Paisán-Ruíz; Shushant Jain; E Whitney Evans; William P Gilks; Javier Simón; Marcel van der Brug; Adolfo López de Munain; Silvia Aparicio; Angel Martínez Gil; Naheed Khan; Janel Johnson; Javier Ruiz Martinez; David Nicholl; Itxaso Martí Carrera; Amets Saénz Pena; Rohan de Silva; Andrew Lees; José Félix Martí-Massó; Jordi Pérez-Tur; Nick W Wood; Andrew B Singleton
Journal:  Neuron       Date:  2004-11-18       Impact factor: 17.173
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  19 in total

1.  Expression by midbrain dopamine neurons of Sema3A and 3F receptors is associated with chemorepulsion in vitro but a mild in vivo phenotype.

Authors:  Enrique R Torre; Claire-Anne Gutekunst; Robert E Gross
Journal:  Mol Cell Neurosci       Date:  2010-03-16       Impact factor: 4.314

2.  Alpha-Synuclein conformation affects its tyrosine-dependent oxidative aggregation.

Authors:  Rebecca A S Ruf; Evan A Lutz; Imola G Zigoneanu; Gary J Pielak
Journal:  Biochemistry       Date:  2008-12-23       Impact factor: 3.162

3.  Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells.

Authors:  Min-fang Xu; Yu-yun Xiong; Jian-kang Liu; Jin-jun Qian; Li Zhu; Jing Gao
Journal:  Acta Pharmacol Sin       Date:  2012-03-26       Impact factor: 6.150

4.  Discovery of sultam-containing small-molecule disruptors of the huntingtin-calmodulin protein-protein interaction.

Authors:  Nicholas J Klus; Khushboo Kapadia; Peter McDonald; Anuradha Roy; Kevin J Frankowski; Nancy A Muma; Jeffrey Aubé
Journal:  Med Chem Res       Date:  2020-06-12       Impact factor: 1.965

Review 5.  Redox proteomics in selected neurodegenerative disorders: from its infancy to future applications.

Authors:  D Allan Butterfield; Marzia Perluigi; Tanea Reed; Tasneem Muharib; Christopher P Hughes; Renã A S Robinson; Rukhsana Sultana
Journal:  Antioxid Redox Signal       Date:  2012-01-18       Impact factor: 8.401

Review 6.  The interrelationship of metabolic syndrome and neurodegenerative diseases with focus on brain-derived neurotrophic factor (BDNF): Kill two birds with one stone.

Authors:  Shima Motamedi; Isaac Karimi; Fariba Jafari
Journal:  Metab Brain Dis       Date:  2017-03-30       Impact factor: 3.584

Review 7.  Emerging roles of epigenetic mechanisms in Parkinson's disease.

Authors:  Ehsan Habibi; Ali Masoudi-Nejad; Hamid Mostafavi Abdolmaleky; Stephen J Haggarty
Journal:  Funct Integr Genomics       Date:  2011-09-04       Impact factor: 3.410

8.  Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study.

Authors:  N Klepac; M Relja; R Klepac; S Hećimović; T Babić; V Trkulja
Journal:  J Neurol       Date:  2007-11-09       Impact factor: 4.849

Review 9.  Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases.

Authors:  Xiao-xia Dong; Yan Wang; Zheng-hong Qin
Journal:  Acta Pharmacol Sin       Date:  2009-04       Impact factor: 6.150

10.  Possible role of Epoxyeicosatrienoic acid in prevention of oxidative stress mediated neuroinflammation in Parkinson disorders.

Authors:  Navya Lakkappa; Praveen T Krishnamurthy; Bruce D Hammock; D Velmurugan; M M Srinivas Bharath
Journal:  Med Hypotheses       Date:  2016-06-05       Impact factor: 1.538
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