Literature DB >> 11425562

Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents.

M L Barreca1, A Chimirri, L De Luca, A M Monforte, P Monforte, A Rao, M Zappalà, J Balzarini, E De Clercq, C Pannecouque, M Witvrouw.   

Abstract

Design, synthesis and anti-HIV activity of a series of 2,3-diaryl-1,3-thiazolidin-4-ones are reported. Some derivatives proved to be highly effective in inhibiting HIV-1 replication at nanomolar concentrations thereby acting as non-nucleoside HIV-1 RT inhibitors (NNRTIs). SAR studies evidenced that the nature of the substituents at the 2 and 3 positions of the thiazolidinone nucleus largely influenced the in vitro anti-HIV activity of this new class of potent antiviral agents.

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Year:  2001        PMID： 11425562     DOI： 10.1016/s0960-894x(01)00304-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  21 in total

1.  Synthesis, Spectroscopic Properties and Antioxidant Activity of Bis-Hydrazones and Schiff's bases Derived from Terephthalic Dihydrazide.

Authors:  H S Vidyashree Jois; Balakrishna Kalluraya; T Vishwanath
Journal:  J Fluoresc       Date:  2015-03-29       Impact factor: 2.217

2.  8-Methyl-4-morpholinoethyl-1-thia-4-aza-spiro-[4.5]decan-3-one.

Authors:  Mehmet Akkurt; Serife Pınar Yalçın; Nalan Terzioğlu Klip; Orhan Büyükgüngör
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-07-23

3.  Synthesis and in vitro antiproliferative activity against human cancer cell lines of novel 5-(4-methyl-benzylidene)-thiazolidine-2,4-diones.

Authors:  S Chandrappa; S B Benaka Prasad; K Vinaya; C S Ananda Kumar; N R Thimmegowda; K S Rangappa
Journal:  Invest New Drugs       Date:  2008-05-13       Impact factor: 3.850

4.  Antimicrobial and antiurease activities of newly synthesized morpholine derivatives containing an azole nucleus.

Authors:  Hakan Bektaş; Sule Ceylan; Neslihan Demirbaş; Sengül Alpay-Karaoğlu; Bahar Bilgin Sökmen
Journal:  Med Chem Res       Date:  2012-11-29       Impact factor: 1.965

5.  2-Imino-3-(2-nitro-phen-yl)-1,3-thia-zolidin-4-one.

Authors:  Muhammad Zia-Ur-Rehman; Mark R J Elsegood; Muhammad Nadeem Arshad; Abdullah M Asiri
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-09-14

6.  3-Benzyl-2-phenyl-1,3-thia-zolidin-4-one.

Authors:  Hoong-Kun Fun; Madhukar Hemamalini; Poovan Shanmugavelan; Alagusundaram Ponnuswamy; Rathinavel Jagatheesan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-09-30

7.  3-Benzyl-2-(furan-2-yl)-1,3-thia-zolidin-4-one.

Authors:  Hoong-Kun Fun; Madhukar Hemamalini; Poovan Shanmugavelan; Alagusundaram Ponnuswamy; Rathinavel Jagatheesan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-09-30

8.  Synthesis of novel inhibitors of α-amylase based on the thiazolidine-4-one skeleton containing a pyrazole moiety and their configurational studies.

Authors:  Parvin Kumar; Meenakshi Duhan; Kulbir Kadyan; Jayant Sindhu; Sunil Kumar; Hitender Sharma
Journal:  Medchemcomm       Date:  2017-05-16       Impact factor: 3.597

9.  Non-nucleoside inhibitors of the hepatitis C virus NS5B RNA-dependant RNA polymerase: 2-aryl-3-heteroaryl-1,3-thiazolidin-4-one derivatives.

Authors:  Ravindra K Rawal; S B Katti; Neerja Kaushik-Basu; Payal Arora; Zhenhua Pan
Journal:  Bioorg Med Chem Lett       Date:  2008-10-08       Impact factor: 2.823

10.  Synthesis of functionalized imidazo[4,5-e]thiazolo[3,2-b]triazines by condensation of imidazo[4,5-e]triazinethiones with DMAD or DEAD and rearrangement to imidazo[4,5-e]thiazolo[2,3-c]triazines.

Authors:  Alexei N Izmest'ev; Dmitry B Vinogradov; Natalya G Kolotyrkina; Angelina N Kravchenko; Galina A Gazieva
Journal:  Beilstein J Org Chem       Date:  2021-05-14       Impact factor: 2.883
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