Literature DB >> 11412975

Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration.

S Ben-Shabat1, C A Parish, M Hashimoto, J Liu, K Nakanishi, J R Sparrow.   

Abstract

The major hydrophobic fluorophore of the retinal pigment epithelium (RPE) is A2E, a pyridinium bis-retinoid derived from all-trans-retinal and phosphatidyl-ethanolamine. The accumulation of fluorophores such as A2E is implicated in the pathogenesis of age-related macular degeneration (AMD), a disease associated with the deterioration of central vision and a leading cause of blindness in the elderly. Recent chemical and biological studies have provided insight into the synthesis and biosynthesis of A2E, the spectroscopic properties of this pigment, and the role of A2E and RPE cell death.

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Year:  2001        PMID： 11412975     DOI： 10.1016/s0960-894x(01)00314-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  25 in total

Review 1.  Ageing of the retinal pigment epithelium: implications for transplantation.

Authors:  Mike Boulton; Malgorzata Róanowska; Tim Wess
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2003-12-09       Impact factor: 3.117

2.  How much blue light should an IOL transmit?

Authors:  M A Mainster; J R Sparrow
Journal:  Br J Ophthalmol       Date:  2003-12       Impact factor: 4.638

3.  Deuterium enrichment of vitamin A at the C20 position slows the formation of detrimental vitamin A dimers in wild-type rodents.

Authors:  Yardana Kaufman; Li Ma; Ilyas Washington
Journal:  J Biol Chem       Date:  2010-11-12       Impact factor: 5.157

4.  The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice.

Authors:  Xiaoguang Cao; Melissa Liu; Jingsheng Tuo; Defen Shen; Chi-Chao Chan
Journal:  Exp Eye Res       Date:  2010-03-31       Impact factor: 3.467

5.  Sublethal photic stress and the motility of RPE phagosomes and melanosomes.

Authors:  Janice M Burke; Mariusz Zareba
Journal:  Invest Ophthalmol Vis Sci       Date:  2008-12-13       Impact factor: 4.799

6.  A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration.

Authors:  Jingsheng Tuo; Robert J Ross; Alexandra A Herzlich; Defen Shen; Xiaoyan Ding; Min Zhou; Steven L Coon; Nahed Hussein; Norman Salem; Chi-Chao Chan
Journal:  Am J Pathol       Date:  2009-07-16       Impact factor: 4.307

7.  Immunochemical recognition of A2E, a pigment in the lipofuscin of retinal pigment epithelial cells.

Authors:  Chandima Abeywickrama; Hiroko Matsuda; Steffen Jockusch; Jilin Zhou; Young P Jang; Bi-Xing Chen; Yasuhiro Itagaki; Bernard F Erlanger; Koji Nakanishi; Nicholas J Turro; Janet R Sparrow
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-05       Impact factor: 11.205

8.  Synthesis of antioxidants for prevention of age-related macular degeneration.

Authors:  Dharati Joshi; James Field; John Murphy; Mohammed Abdelrahim; Heike Schönherr; Janet R Sparrow; George Ellestad; Koji Nakanishi; Arie Zask
Journal:  J Nat Prod       Date:  2013-01-24       Impact factor: 4.050

Review 9.  Genetics and molecular pathology of Stargardt-like macular degeneration.

Authors:  Vidyullatha Vasireddy; Paul Wong; Radha Ayyagari
Journal:  Prog Retin Eye Res       Date:  2010-01-21       Impact factor: 21.198

10.  Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration.

Authors:  Jingsheng Tuo; Christine M Bojanowski; Min Zhou; Defen Shen; Robert J Ross; Kevin I Rosenberg; D Joshua Cameron; Chunyue Yin; Jeffrey A Kowalak; Zhengping Zhuang; Kang Zhang; Chi-Chao Chan
Journal:  Invest Ophthalmol Vis Sci       Date:  2007-08       Impact factor: 4.799
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