Literature DB >> 14663593

Ageing of the retinal pigment epithelium: implications for transplantation.

Mike Boulton1, Malgorzata Róanowska, Tim Wess.   

Abstract

This review will discuss some of the implications for using cells from aged donors for retinal pigment epithelium (RPE) transplantation. It will consider age-related changes in the structure and function of RPE cells and the accumulation of potentially damaging photoreactive constituents. The review will focus on the role of the ocular pigments lipofuscin and melanin in respect to age-related changes in composition, photoreactivity and potential role in retinal ageing and age-related macular degeneration. The article concludes by considering the suitability of senescent RPE cells for transplantation and whether such cells can be rejuvenated.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 14663593     DOI： 10.1007/s00417-003-0812-8

Source DB:  PubMed          Journal:  Graefes Arch Clin Exp Ophthalmol        ISSN： 0721-832X            Impact factor:   3.117


  66 in total

Review 1.  Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration.

Authors:  S Ben-Shabat; C A Parish; M Hashimoto; J Liu; K Nakanishi; J R Sparrow
Journal:  Bioorg Med Chem Lett       Date:  2001-06-18       Impact factor: 2.823

2.  Photochemical studies of A2-E.

Authors:  A Cantrell; D J McGarvey; J Roberts; T Sarna; T G Truscott
Journal:  J Photochem Photobiol B       Date:  2001-11-15       Impact factor: 6.252

3.  Spectroscopic and morphological studies of human retinal lipofuscin granules.

Authors:  Nicole M Haralampus-Grynaviski; Laura E Lamb; Christine M R Clancy; Christine Skumatz; Janice M Burke; Tadeusz Sarna; John D Simon
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-28       Impact factor: 11.205

4.  Antioxidant enzymes in the aging human retinal pigment epithelium.

Authors:  M R Liles; D A Newsome; P D Oliver
Journal:  Arch Ophthalmol       Date:  1991-09

Review 5.  Senescence of the retinal pigmented epithelium.

Authors:  L M Hjelmeland
Journal:  Invest Ophthalmol Vis Sci       Date:  1999-01       Impact factor: 4.799

6.  Retinal age pigments generated by self-assembling lysosomotropic detergents.

Authors:  G E Eldred; M R Lasky
Journal:  Nature       Date:  1993-02-25       Impact factor: 49.962

7.  The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.

Authors:  J R Sparrow; K Nakanishi; C A Parish
Journal:  Invest Ophthalmol Vis Sci       Date:  2000-06       Impact factor: 4.799

8.  Age-related macular degeneration. The lipofusion component N-retinyl-N-retinylidene ethanolamine detaches proapoptotic proteins from mitochondria and induces apoptosis in mammalian retinal pigment epithelial cells.

Authors:  M Suter; C Remé; C Grimm; A Wenzel; M Jäättela; P Esser; N Kociok; M Leist; C Richter
Journal:  J Biol Chem       Date:  2000-12-15       Impact factor: 5.157

Review 9.  The role of oxidative stress in the pathogenesis of age-related macular degeneration.

Authors:  S Beatty; H Koh; M Phil; D Henson; M Boulton
Journal:  Surv Ophthalmol       Date:  2000 Sep-Oct       Impact factor: 6.048

10.  AAV-Mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa.

Authors:  Alexander J Smith; Frank C Schlichtenbrede; Marion Tschernutter; James W Bainbridge; Adrian J Thrasher; Robin R Ali
Journal:  Mol Ther       Date:  2003-08       Impact factor: 11.454
View more
  17 in total

Review 1.  Roles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degeneration.

Authors:  Fu Shang; Allen Taylor
Journal:  Mol Aspects Med       Date:  2012-04-10

2.  Epidermal growth factor: the driving force in initiation of RPE cell proliferation.

Authors:  Kerstin Steindl-Kuscher; Michael E Boulton; Paulina Haas; Astrid Dossenbach-Glaninger; Hans Feichtinger; Susanne Binder
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2011-04-15       Impact factor: 3.117

3.  Differential behavioral outcomes following neonatal versus fetal human retinal pigment epithelial cell striatal implants in parkinsonian rats.

Authors:  Kaspar Russ; Joseph Flores; Tomasz Brudek; Doris J Doudet
Journal:  J Neural Transm (Vienna)       Date:  2017-02-04       Impact factor: 3.575

4.  Enhanced retinal pigment epithelium regeneration after injury in MRL/MpJ mice.

Authors:  Huiming Xia; Mark P Krebs; Shalesh Kaushal; Edward W Scott
Journal:  Exp Eye Res       Date:  2011-10-06       Impact factor: 3.467

5.  Multiplex analysis of age-related protein and lipid modifications in human Bruch's membrane.

Authors:  J Renwick Beattie; Anna M Pawlak; Michael E Boulton; Jianye Zhang; Vincent M Monnier; John J McGarvey; Alan W Stitt
Journal:  FASEB J       Date:  2010-08-04       Impact factor: 5.191

6.  Proteasome-dependent regulation of signal transduction in retinal pigment epithelial cells.

Authors:  Alexandre F Fernandes; Weimin Guo; Xinyu Zhang; Matthew Gallagher; Mircea Ivan; Allen Taylor; Paulo Pereira; Fu Shang
Journal:  Exp Eye Res       Date:  2006-10-05       Impact factor: 3.467

Review 7.  The ubiquitin-proteasome system in retinal health and disease.

Authors:  Laura Campello; Julián Esteve-Rudd; Nicolás Cuenca; José Martín-Nieto
Journal:  Mol Neurobiol       Date:  2013-01-22       Impact factor: 5.590

8.  Proteasome inactivation promotes p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation and increases interleukin-8 production in retinal pigment epithelial cells.

Authors:  Alexandre F Fernandes; Qingning Bian; Jian-Kang Jiang; Craig J Thomas; Allen Taylor; Paulo Pereira; Fu Shang
Journal:  Mol Biol Cell       Date:  2009-07-01       Impact factor: 4.138

9.  Oxidative inactivation of the proteasome in retinal pigment epithelial cells. A potential link between oxidative stress and up-regulation of interleukin-8.

Authors:  Alexandre F Fernandes; Jilin Zhou; Xinyu Zhang; Qingning Bian; Janet Sparrow; Allen Taylor; Paulo Pereira; Fu Shang
Journal:  J Biol Chem       Date:  2008-05-23       Impact factor: 5.157

10.  Reduction of iatrogenic RPE lesions in AMD patients: evidence for wound healing?

Authors:  Doris Rabenlehner; Boris V Stanzel; Ilse Krebs; Susanne Binder; Alexandra Goll
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2007-08-18       Impact factor: 3.117
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.