Literature DB >> 14660465

How much blue light should an IOL transmit?

M A Mainster1, J R Sparrow.   

Abstract

Older, and even some modern, intraocular lenses (IOLs) transmit potentially hazardous ultraviolet radiation (UVR) to the retina. In addition, IOLs transmit more blue and green light to the retina for scotopic vision than the crystalline lenses they replace, light that is also potentially hazardous. The severity of UVR-blue type phototoxicity increases with decreasing wavelength, unlike the action spectrum of blue-green type retinal phototoxicity and the luminous efficiency of scotopic vision which both peak in the blue-green part of the optical spectrum around 500 nm. Theoretically, UVR+blue absorbing IOLs provide better retinal protection but worse scotopic sensitivity than UVR-only absorbing IOLs, but further study is needed to test this analysis. UVR is potentially hazardous and not useful for vision, so it is prudent to protect the retina from it with chromophores in IOLs. Determining authoritatively how much blue light an optimal IOL should block requires definitive studies to determine (1) the action spectrum of the retinal phototoxicity potentially involved in human retinal ageing, and (2) the amount of shorter wavelength blue light required for older adults to perform essential activities in dimly lit environments.

Entities:  

Mesh:

Year:  2003        PMID: 14660465      PMCID: PMC1920564          DOI: 10.1136/bjo.87.12.1523

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN: 0007-1161            Impact factor:   4.638


  151 in total

1.  Cataract surgery in patients with cataract and age related macular degeneration: do the benefits outweigh the risks?

Authors:  T Y Wong
Journal:  Br J Ophthalmol       Date:  2000-12       Impact factor: 4.638

2.  Is cataract surgery justified in patients with age related macular degeneration? A visual function and quality of life assessment.

Authors:  A M Armbrecht; C Findlay; S Kaushal; P Aspinall; A R Hill; B Dhillon
Journal:  Br J Ophthalmol       Date:  2000-12       Impact factor: 4.638

3.  Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl-2.

Authors:  J R Sparrow; B Cai
Journal:  Invest Ophthalmol Vis Sci       Date:  2001-05       Impact factor: 4.799

4.  Rhodopsin-mediated blue-light damage to the rat retina: effect of photoreversal of bleaching.

Authors:  C Grimm; A Wenzel; T Williams; P Rol; F Hafezi; C Remé
Journal:  Invest Ophthalmol Vis Sci       Date:  2001-02       Impact factor: 4.799

5.  Circadian-dependent retinal light damage in rats.

Authors:  D T Organisciak; R M Darrow; L Barsalou; R K Kutty; B Wiggert
Journal:  Invest Ophthalmol Vis Sci       Date:  2000-11       Impact factor: 4.799

6.  Blue light's effects on rhodopsin: photoreversal of bleaching in living rat eyes.

Authors:  C Grimm; C E Remé; P O Rol; T P Williams
Journal:  Invest Ophthalmol Vis Sci       Date:  2000-11       Impact factor: 4.799

7.  Gene expression in the mouse retina: the effect of damaging light.

Authors:  C Grimm; A Wenzel; F Hafezi; C E Remé
Journal:  Mol Vis       Date:  2000-12-13       Impact factor: 2.367

8.  Age-related macular degeneration. The lipofusion component N-retinyl-N-retinylidene ethanolamine detaches proapoptotic proteins from mitochondria and induces apoptosis in mammalian retinal pigment epithelial cells.

Authors:  M Suter; C Remé; C Grimm; A Wenzel; M Jäättela; P Esser; N Kociok; M Leist; C Richter
Journal:  J Biol Chem       Date:  2000-12-15       Impact factor: 5.157

9.  Sunlight and the 5-year incidence of early age-related maculopathy: the beaver dam eye study.

Authors:  K J Cruickshanks; R Klein; B E Klein; D M Nondahl
Journal:  Arch Ophthalmol       Date:  2001-02

Review 10.  The role of oxidative stress in the pathogenesis of age-related macular degeneration.

Authors:  S Beatty; H Koh; M Phil; D Henson; M Boulton
Journal:  Surv Ophthalmol       Date:  2000 Sep-Oct       Impact factor: 6.048

View more
  25 in total

1.  Blue light and the circadian clock.

Authors:  R N Van Gelder
Journal:  Br J Ophthalmol       Date:  2004-10       Impact factor: 4.638

2.  Measurements of transmission spectrums and estimation of retinal blue-light irradiance values of currently available clear and yellow-tinted intraocular lenses.

Authors:  Masaki Tanito; Tsutomu Okuno; Yoshihisa Ishiba; Akihiro Ohira
Journal:  Jpn J Ophthalmol       Date:  2011-11-19       Impact factor: 2.447

3.  Visual function in patients with yellow tinted intraocular lenses compared with vision in patients with non-tinted intraocular lenses.

Authors:  K Hayashi; H Hayashi
Journal:  Br J Ophthalmol       Date:  2006-04-05       Impact factor: 4.638

Review 4.  Blocking the blue.

Authors:  P Hawse
Journal:  Br J Ophthalmol       Date:  2006-08       Impact factor: 4.638

5.  Spectral transmission of intraocular lenses expressed as a virtual age.

Authors:  Dirk van Norren; Jan van de Kraats
Journal:  Br J Ophthalmol       Date:  2007-10       Impact factor: 4.638

6.  Scotopic sensitivity and color vision with a blue-light-absorbing intraocular lens.

Authors:  Vivienne C Greenstein; Flavia Chiosi; Paul Baker; William Seiple; Karen Holopigian; Richard E Braunstein; Janet R Sparrow
Journal:  J Cataract Refract Surg       Date:  2007-04       Impact factor: 3.351

7.  All-distance visual acuity in eyes with a nontinted or a yellow-tinted diffractive multifocal intraocular lens.

Authors:  Ken Hayashi; Miki Masumoto; Hideyuki Hayashi
Journal:  Jpn J Ophthalmol       Date:  2009-03-31       Impact factor: 2.447

8.  Blue-blocking intraocular implants should be used routinely during phacoemulsification surgery--yes.

Authors:  R J Symes; F M Cuthbertson
Journal:  Eye (Lond)       Date:  2012-09-07       Impact factor: 3.775

9.  Blue-blocking intraocular implants should be used routinely during phacoemulsification surgery--no.

Authors:  R M H Lee; F C Lam; C S C Liu
Journal:  Eye (Lond)       Date:  2012-09-07       Impact factor: 3.775

10.  A model of spectral filtering to reduce photochemical damage in age-related macular degeneration.

Authors:  Sanford M Meyers; Mikhail A Ostrovsky; Robert F Bonner
Journal:  Trans Am Ophthalmol Soc       Date:  2004
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.