Literature DB >> 23346866

Synthesis of antioxidants for prevention of age-related macular degeneration.

Dharati Joshi1, James Field, John Murphy, Mohammed Abdelrahim, Heike Schönherr, Janet R Sparrow, George Ellestad, Koji Nakanishi, Arie Zask.   

Abstract

Photooxidation of A2E may be involved in diseases of the macula, and antioxidants could serve as therapeutic agents for these diseases. Inhibitors of A2E photooxidation were prepared by Mannich reaction of the antioxidant quercetin. These compounds contain water-solubilizing amine groups, and several were more potent inhibitors of A2E photooxidation than quercetin.

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Year:  2013        PMID： 23346866      PMCID： PMC4069254          DOI： 10.1021/np300769c

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  13 in total

1.  A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture.

Authors:  J R Sparrow; C A Parish; M Hashimoto; K Nakanishi
Journal:  Invest Ophthalmol Vis Sci       Date:  1999-11       Impact factor: 4.799

Review 2.  Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration.

Authors:  S Ben-Shabat; C A Parish; M Hashimoto; J Liu; K Nakanishi; J R Sparrow
Journal:  Bioorg Med Chem Lett       Date:  2001-06-18       Impact factor: 2.823

3.  Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin.

Authors:  Shimon Ben-Shabat; Craig A Parish; Heidi R Vollmer; Yasuhiro Itagaki; Nathan Fishkin; Koji Nakanishi; Janet R Sparrow
Journal:  J Biol Chem       Date:  2001-12-26       Impact factor: 5.157

4.  Deuterium enrichment of vitamin A at the C20 position slows the formation of detrimental vitamin A dimers in wild-type rodents.

Authors:  Yardana Kaufman; Li Ma; Ilyas Washington
Journal:  J Biol Chem       Date:  2010-11-12       Impact factor: 5.157

5.  Superoxidation of bisretinoids.

Authors:  Ilyas Washington; Steffen Jockusch; Yasuhiro Itagaki; Nicholas J Turro; Koji Nakanishi
Journal:  Angew Chem Int Ed Engl       Date:  2005-11-04       Impact factor: 15.336

6.  Predicting the activity of phenolic antioxidants: theoretical method, analysis of substituent effects, and application to major families of antioxidants.

Authors:  J S Wright; E R Johnson; G A DiLabio
Journal:  J Am Chem Soc       Date:  2001-02-14       Impact factor: 15.419

7.  The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.

Authors:  J R Sparrow; K Nakanishi; C A Parish
Journal:  Invest Ophthalmol Vis Sci       Date:  2000-06       Impact factor: 4.799

8.  Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE.

Authors:  Janet R Sparrow; Jilin Zhou; Shimon Ben-Shabat; Heidi Vollmer; Yasuhiro Itagaki; Koji Nakanishi
Journal:  Invest Ophthalmol Vis Sci       Date:  2002-04       Impact factor: 4.799

9.  A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation.

Authors:  Janet R Sparrow; Heidi R Vollmer-Snarr; Jilin Zhou; Young P Jang; Steffen Jockusch; Yasuhiro Itagaki; Koji Nakanishi
Journal:  J Biol Chem       Date:  2003-03-19       Impact factor: 5.157

10.  Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium.

Authors:  C A Parish; M Hashimoto; K Nakanishi; J Dillon; J Sparrow
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-08       Impact factor: 11.205
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  6 in total

1.  Therapeutic Benefits from Nanoparticles: The Potential Significance of Nanoscience in Retinal Degenerative Diseases.

Authors:  Raju V S Rajala
Journal:  J Mol Biol Ther       Date:  2019

2.  Validation of genome-wide association study (GWAS)-identified disease risk alleles with patient-specific stem cell lines.

Authors:  Jin Yang; Yao Li; Lawrence Chan; Yi-Ting Tsai; Wen-Hsuan Wu; Huy V Nguyen; Chun-Wei Hsu; Xiaorong Li; Lewis M Brown; Dieter Egli; Janet R Sparrow; Stephen H Tsang
Journal:  Hum Mol Genet       Date:  2014-02-04       Impact factor: 6.150

Review 3.  Mannich bases in medicinal chemistry and drug design.

Authors:  Gheorghe Roman
Journal:  Eur J Med Chem       Date:  2014-10-30       Impact factor: 6.514

4.  Synthesis and antiproliferative activity of pterostilbene and 3′-methoxy pterostilbene Mannich base derivatives against Hela cells.

Authors:  Chongyang Liu; Linpei Dong; Shengchun Wang; Qiuan Wang
Journal:  Mol Divers       Date:  2015-07-11       Impact factor: 2.943

5.  Synthesis and Biological Evaluation of Novel Alkyl Amine Substituted Icariside II Derivatives as Potential Anticancer Agents.

Authors:  Tong Wu; Ting Li; Ya-Nan Kang; Li Liu; Xi-Man Wang; Jin-Shuai Lan; Yue Ding; Tong Zhang
Journal:  Molecules       Date:  2018-08-27       Impact factor: 4.411

6.  Anti-angiogenic effect of quercetin and its 8-methyl pentamethyl ether derivative in human microvascular endothelial cells.

Authors:  Gabriella Lupo; Maria Teresa Cambria; Melania Olivieri; Concetta Rocco; Nunzia Caporarello; Anna Longo; Guido Zanghì; Mario Salmeri; Mario C Foti; Carmelina Daniela Anfuso
Journal:  J Cell Mol Med       Date:  2019-08-01       Impact factor: 5.310
  6 in total

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