Literature DB >> 11408239

Molecular characterization of a novel plasmid-encoded cefotaximase (CTX-M-12) found in clinical Klebsiella pneumoniae isolates from Kenya.

S Kariuki1, J E Corkill, G Revathi, R Musoke, C A Hart.   

Abstract

Nine Klebsiella pneumoniae isolates, six from blood and three from cerebrospinal fluid of newborn babies at Kenyatta National Hospital, Nairobi, Kenya, were analyzed for the mechanism of cephalosporin resistance. By using pulsed-field gel electrophoresis of XbaI-digested chromosomal DNA, all the nine isolates were found to be clonal. PCR and direct sequencing revealed a novel extended-spectrum beta-lactamase, which we designated CTX-M-12. It has a more potent hydrolytic activity against cefotaxime than against ceftazidime and a pI of 9.0 and is encoded on a large self-transferable ca. 160-kbp plasmid.

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Year:  2001        PMID： 11408239      PMCID： PMC90616          DOI： 10.1128/AAC.45.7.2141-2143.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

Review 1.  Evolution and spread of SHV extended-spectrum beta-lactamases in gram-negative bacteria.

Authors:  J Heritage; F H M'Zali; D Gascoyne-Binzi; P M Hawkey
Journal:  J Antimicrob Chemother       Date:  1999-09       Impact factor: 5.790

2.  Nucleotide sequence and characterization of a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-10) isolated in Spain.

Authors:  A Oliver; J C Pérez-Díaz; T M Coque; F Baquero; R Cantón
Journal:  Antimicrob Agents Chemother       Date:  2001-02       Impact factor: 5.191

3.  Emergence of multidrug-resistant gram-negative organisms in a neonatal unit and the therapeutic implications.

Authors:  R N Musoke; G Revathi
Journal:  J Trop Pediatr       Date:  2000-04       Impact factor: 1.165

4.  Cloning and sequence of the gene encoding a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-9) from Escherichia coli in Spain.

Authors:  M Sabaté; R Tarragó; F Navarro; E Miró; C Vergés; J Barbé; G Prats
Journal:  Antimicrob Agents Chemother       Date:  2000-07       Impact factor: 5.191

5.  A standard numbering scheme for the class A beta-lactamases.

Authors:  R P Ambler; A F Coulson; J M Frère; J M Ghuysen; B Joris; M Forsman; R C Levesque; G Tiraby; S G Waley
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

6.  A guide to sensitivity testing. Report of the Working Party on Antibiotic Sensitivity Testing of the British Society for Antimicrobial Chemotherapy.

Authors: 
Journal:  J Antimicrob Chemother       Date:  1991-06       Impact factor: 5.790

7.  Characterization of self-transmissible plasmids determining lactose fermentation and multiple antibiotic resistance in clinical strains of Klebsiella pneumoniae.

Authors:  S K Walia; T Madhavan; T D Chugh; K B Sharma
Journal:  Plasmid       Date:  1987-01       Impact factor: 3.466

8.  A novel CTX-M beta-lactamase (CTX-M-8) in cefotaxime-resistant Enterobacteriaceae isolated in Brazil.

Authors:  R Bonnet; J L Sampaio; R Labia; C De Champs; D Sirot; C Chanal; J Sirot
Journal:  Antimicrob Agents Chemother       Date:  2000-07       Impact factor: 5.191

9.  Analysis of Salmonella enterica serotype Typhimurium by phage typing, antimicrobial susceptibility and pulsed-field gel electrophoresis.

Authors:  S Kariuki; C Gilks; J Kimari; J Muyodi; P Waiyaki; C A Hart
Journal:  J Med Microbiol       Date:  1999-11       Impact factor: 2.472

10.  Occurrence and detection of AmpC beta-lactamases among Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates at a veterans medical center.

Authors:  P E Coudron; E S Moland; K S Thomson
Journal:  J Clin Microbiol       Date:  2000-05       Impact factor: 5.948
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  34 in total

1.  Characterization of a chromosomally encoded extended-spectrum class A beta-lactamase from Kluyvera cryocrescens.

Authors:  J W Decousser; L Poirel; P Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

2.  Countrywide spread of CTX-M-3 extended-spectrum beta-lactamase-producing microorganisms of the family Enterobacteriaceae in Poland.

Authors:  Anna Baraniak; Janusz Fiett; Agnieszka Sulikowska; Waleria Hryniewicz; Marek Gniadkowski
Journal:  Antimicrob Agents Chemother       Date:  2002-01       Impact factor: 5.191

3.  Plasmidic extended-spectrum beta-lactamases in Vibrio cholerae O1 El Tor isolates in Argentina.

Authors:  Alejandro Petroni; Alejandra Corso; Roberto Melano; María Luisa Cacace; Ana María Bru; Alicia Rossi; Marcelo Galas
Journal:  Antimicrob Agents Chemother       Date:  2002-05       Impact factor: 5.191

4.  Three cefotaximases, CTX-M-9, CTX-M-13, and CTX-M-14, among Enterobacteriaceae in the People's Republic of China.

Authors:  Aroonwadee Chanawong; Fatima Hannachi M'Zali; John Heritage; Jian-Hui Xiong; Peter Michael Hawkey
Journal:  Antimicrob Agents Chemother       Date:  2002-03       Impact factor: 5.191

Review 5.  Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes.

Authors:  R Bonnet
Journal:  Antimicrob Agents Chemother       Date:  2004-01       Impact factor: 5.191

6.  Beta-lactamases of Kluyvera ascorbata, probable progenitors of some plasmid-encoded CTX-M types.

Authors:  Christel Humeniuk; Guillaume Arlet; Valerie Gautier; Patrick Grimont; Roger Labia; Alain Philippon
Journal:  Antimicrob Agents Chemother       Date:  2002-09       Impact factor: 5.191

7.  High-level resistance to ceftazidime conferred by a novel enzyme, CTX-M-32, derived from CTX-M-1 through a single Asp240-Gly substitution.

Authors:  Monica Cartelle; Maria del Mar Tomas; Francisca Molina; Rita Moure; Rosa Villanueva; German Bou
Journal:  Antimicrob Agents Chemother       Date:  2004-06       Impact factor: 5.191

8.  High Diversity of CTX-M Extended-Spectrum β-Lactamases in Municipal Wastewater and Urban Wetlands.

Authors:  Timothy R Borgogna; Joanna-Lynn Borgogna; Jenna A Mielke; Celeste J Brown; Eva M Top; Ryan T Botts; David E Cummings
Journal:  Microb Drug Resist       Date:  2015-12-15       Impact factor: 3.431

9.  Molecular epidemiological analysis of Escherichia coli isolates producing extended-spectrum beta-lactamases for identification of nosocomial outbreaks in Stockholm, Sweden.

Authors:  Hong Fang; Christina Lundberg; Barbro Olsson-Liljequist; Göran Hedin; Emma Lindbäck; Asa Rosenberg; Johan Struwe
Journal:  J Clin Microbiol       Date:  2004-12       Impact factor: 5.948

10.  Recent Emergence of Escherichia coli with Cephalosporin Resistance Conferred by blaCTX-M on Washington State Dairy Farms.

Authors:  Margaret A Davis; William M Sischo; Lisa P Jones; Dale A Moore; Sara Ahmed; Diana M Short; Thomas E Besser
Journal:  Appl Environ Microbiol       Date:  2015-04-24       Impact factor: 4.792
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