| Literature DB >> 12183268 |
Christel Humeniuk1, Guillaume Arlet, Valerie Gautier, Patrick Grimont, Roger Labia, Alain Philippon.
Abstract
Kluyvera ascorbata produces a beta-lactamase that results in an atypical susceptibility pattern, including low-level resistance to penicillins, cephalothin, and cefuroxime, but this resistance is reversed by clavulanate. Ten nucleotide sequences of the corresponding gene, bla(KLUA), were obtained and were found to have minor variations (96 to 100%). Otherwise, bla(KLUA) was found to be similar (95 to 100%) to some plasmid-encoded CTX-M-type beta-lactamases. Finally, mobilization of bla(KLUA) on a plasmid was found to be mediated probably by a genetic mobile element like ISEcp1.Entities:
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Year: 2002 PMID: 12183268 PMCID: PMC127423 DOI: 10.1128/AAC.46.9.3045-3049.2002
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191