Literature DB >> 15155242

High-level resistance to ceftazidime conferred by a novel enzyme, CTX-M-32, derived from CTX-M-1 through a single Asp240-Gly substitution.

Monica Cartelle1, Maria del Mar Tomas, Francisca Molina, Rita Moure, Rosa Villanueva, German Bou.   

Abstract

A clinical strain of Escherichia coli isolated from pleural liquid with high levels of resistance to cefotaxime, ceftazidime, and aztreonam harbors a novel CTX-M gene (bla(CTX-M-32)) whose amino acid sequence differs from that of CTX-M-1 by a single Asp240-Gly substitution. Moreover, by site-directed mutagenesis we demonstrated that this replacement is a key event in ceftazidime hydrolysis

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Year:  2004        PMID： 15155242      PMCID： PMC415568          DOI： 10.1128/AAC.48.6.2308-2313.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  Nucleotide sequence and characterization of a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-10) isolated in Spain.

Authors:  A Oliver; J C Pérez-Díaz; T M Coque; F Baquero; R Cantón
Journal:  Antimicrob Agents Chemother       Date:  2001-02       Impact factor: 5.191

2.  Salmonella enterica serovar virchow with CTX-M-like beta-lactamase in Spain.

Authors:  E Simarro; F Navarro; J Ruiz; E Miró; J Gómez; B Mirelis
Journal:  J Clin Microbiol       Date:  2000-12       Impact factor: 5.948

Review 3.  Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.

Authors:  P A Bradford
Journal:  Clin Microbiol Rev       Date:  2001-10       Impact factor: 26.132

4.  Molecular characterization of a novel plasmid-encoded cefotaximase (CTX-M-12) found in clinical Klebsiella pneumoniae isolates from Kenya.

Authors:  S Kariuki; J E Corkill; G Revathi; R Musoke; C A Hart
Journal:  Antimicrob Agents Chemother       Date:  2001-07       Impact factor: 5.191

5.  Sequences of beta-lactamase genes encoding CTX-M-1 (MEN-1) and CTX-M-2 and relationship of their amino acid sequences with those of other beta-lactamases.

Authors:  A Bauernfeind; I Stemplinger; R Jungwirth; S Ernst; J M Casellas
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

6.  A novel CTX-M beta-lactamase (CTX-M-8) in cefotaxime-resistant Enterobacteriaceae isolated in Brazil.

Authors:  R Bonnet; J L Sampaio; R Labia; C De Champs; D Sirot; C Chanal; J Sirot
Journal:  Antimicrob Agents Chemother       Date:  2000-07       Impact factor: 5.191

7.  CTX-M-1, CTX-M-3, and CTX-M-14 beta-lactamases from Enterobacteriaceae isolated in France.

Authors:  C Dutour; R Bonnet; H Marchandin; M Boyer; C Chanal; D Sirot; J Sirot
Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

8.  Genes encoding TEM-4, SHV-2, and CTX-M-10 extended-spectrum beta-lactamases are carried by multiple Klebsiella pneumoniae clones in a single hospital (Madrid, 1989 to 2000).

Authors:  Teresa M Coque; Antonio Oliver; José Claudio Pérez-Díaz; Fernando Baquero; Rafael Cantón
Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

9.  Novel cefotaximase (CTX-M-16) with increased catalytic efficiency due to substitution Asp-240-->Gly.

Authors:  R Bonnet; C Dutour; J L Sampaio; C Chanal; D Sirot; R Labia; C De Champs; J Sirot
Journal:  Antimicrob Agents Chemother       Date:  2001-08       Impact factor: 5.191

10.  CTX-M-type extended-spectrum beta-lactamase that hydrolyzes ceftazidime through a single amino acid substitution in the omega loop.

Authors:  L Poirel; T Naas; I Le Thomas; A Karim; E Bingen; P Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191
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  32 in total

1.  Characterization of IncA/C conjugative plasmid harboring bla TEM-52 and bla CTX-M-15 extended-spectrum β-lactamases in clinical isolates of Escherichia coli in Tunisia.

Authors:  C Chouchani; A El Salabi; R Marrakchi; L Ferchichi; T R Walsh
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2011-09-22       Impact factor: 3.267

2.  Monitoring and characterization of extended-spectrum beta-lactamases in Escherichia coli strains from healthy and sick animals in Spain in 2003.

Authors:  Laura Briñas; Miguel Angel Moreno; Tirushet Teshager; Yolanda Sáenz; María Concepción Porrero; Lucas Domínguez; Carmen Torres
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

3.  Transcriptional analysis of the bla(CTX-M-2) gene in Salmonella enterica serovar Infantis.

Authors:  José A Di Conza; Gabriel O Gutkind; Marta E Mollerach; Juan A Ayala
Journal:  Antimicrob Agents Chemother       Date:  2005-07       Impact factor: 5.191

4.  Detection of CTX-M-1, CTX-M-15, and CTX-M-2 in clinical isolates of Enterobacteriaceae in Bogota, Colombia.

Authors:  Emilia María Valenzuela de Silva; José Ramón Mantilla Anaya; María Teresa Reguero Reza; Elsa Beatriz González Mejía; Ingrid Yamile Pulido Manrique; Iván Darío Llerena; Daniel Velandia
Journal:  J Clin Microbiol       Date:  2006-05       Impact factor: 5.948

5.  Emergence and dissemination of Enterobacteriaceae isolates producing CTX-M-1-like enzymes in Spain are associated with IncFII (CTX-M-15) and broad-host-range (CTX-M-1, -3, and -32) plasmids.

Authors:  Angela Novais; Rafael Cantón; Raquel Moreira; Luísa Peixe; Fernando Baquero; Teresa M Coque
Journal:  Antimicrob Agents Chemother       Date:  2006-12-04       Impact factor: 5.191

6.  Prediction of the evolution of ceftazidime resistance in extended-spectrum beta-lactamase CTX-M-9.

Authors:  J Delmas; F Robin; F Carvalho; C Mongaret; R Bonnet
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

7.  Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance.

Authors:  Angela Novais; Rafael Cantón; Teresa M Coque; Andrés Moya; Fernando Baquero; Juan Carlos Galán
Journal:  Antimicrob Agents Chemother       Date:  2008-04-28       Impact factor: 5.191

8.  CTX-M-type extended-spectrum beta-lactamases in Italy: molecular epidemiology of an emerging countrywide problem.

Authors:  Claudia Mugnaioli; Francesco Luzzaro; Filomena De Luca; Gioconda Brigante; Mariagrazia Perilli; Gianfranco Amicosante; Stefania Stefani; Antonio Toniolo; Gian Maria Rossolini
Journal:  Antimicrob Agents Chemother       Date:  2006-08       Impact factor: 5.191

9.  Distant and new mutations in CTX-M-1 beta-lactamase affect cefotaxime hydrolysis.

Authors:  Francisco José Pérez-Llarena; Frédéric Kerff; Olga Abián; Susana Mallo; María Carmen Fernández; Moreno Galleni; Javier Sancho; Germán Bou
Journal:  Antimicrob Agents Chemother       Date:  2011-07-05       Impact factor: 5.191

10.  Molecular characterization of CTX-M β-lactamase and associated addiction systems in Escherichia coli circulating among cattle, farm workers, and the farm environment.

Authors:  Migma Dorji Tamang; Hyang-Mi Nam; Mamata Gurung; Geum-Chan Jang; Su-Ran Kim; Suk-Chan Jung; Yong Ho Park; Suk-Kyung Lim
Journal:  Appl Environ Microbiol       Date:  2013-04-12       Impact factor: 4.792
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