Literature DB >> 11347961

Structure-based design of non-peptide HIV protease inhibitors.

A K Ghosh1, D Shin, L Swanson, K Krishnan, H Cho, K A Hussain, D E Walters, L Holland, J Buthod.   

Abstract

A number of structurally novel P2-ligands have been designed and synthesized. Incorporation of these ligands in the (R)-(hydroxyethyl)sulfonamide isostere provided a series of potent non-peptidyl HIV protease inhibitors.

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Year:  2001        PMID： 11347961     DOI： 10.1016/s0014-827x(01)01025-4

Source DB:  PubMed          Journal:  Farmaco        ISSN： 0014-827X


  11 in total

1.  MULTICOMPONENT REACTIONS: SYNTHESIS OF SPIROCYCLIC TETRAHYDROPYRAN DERIVATIVES BY PRINS CYCLIZATION.

Authors:  Arun K Ghosh; Dongwoo Shin; Gary Schiltz
Journal:  Heterocycles       Date:  2002       Impact factor: 0.831

2.  Synthesis of Spirocyclic Ethers by Enantioselective Copper-Catalyzed Carboetherification of Alkenols.

Authors:  Shuklendu D Karyakarte; Chanchamnan Um; Ilyas A Berhane; Sherry R Chemler
Journal:  Angew Chem Int Ed Engl       Date:  2018-09-03       Impact factor: 15.336

3.  A Stereoselective Anti-Aldol Route to (3R,3aS,6aR)-Hexahydrofuro[2,3-b] furan-3-ol: A Key Ligand for a New Generation of HIV Protease Inhibitors.

Authors:  Arun K Ghosh; Jianfeng Li; Ramu Sridhar Perali
Journal:  Synthesis (Stuttg)       Date:  2006-09       Impact factor: 3.157

4.  Synthesis of Bioactive Natural Products by Asymmetric syn- and anti-Aldol Reactions.

Authors:  Arun K Ghosh; Zachary L Dawson
Journal:  Synthesis (Stuttg)       Date:  2009-09       Impact factor: 3.157

5.  Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV-1 Protease Inhibitors.

Authors:  Arun K Ghosh; Margherita Brindisi
Journal:  Asian J Org Chem       Date:  2018-06-08       Impact factor: 3.319

6.  Capturing the essence of organic synthesis: from bioactive natural products to designed molecules in today's medicine.

Authors:  Arun K Ghosh
Journal:  J Org Chem       Date:  2010-10-11       Impact factor: 4.354

7.  Probing multidrug-resistance and protein-ligand interactions with oxatricyclic designed ligands in HIV-1 protease inhibitors.

Authors:  Arun K Ghosh; Chun-Xiao Xu; Kalapala Venkateswara Rao; Abigail Baldridge; Johnson Agniswamy; Yuan-Fang Wang; Irene T Weber; Manabu Aoki; Salcedo Gomez Pedro Miguel; Masayuki Amano; Hiroaki Mitsuya
Journal:  ChemMedChem       Date:  2010-11-08       Impact factor: 3.466

8.  Selective Targeting of Cells via Bispecific Molecules That Exploit Coexpression of Two Intracellular Proteins.

Authors:  Bryan M Dunyak; Robert L Nakamura; Alan D Frankel; Jason E Gestwicki
Journal:  ACS Chem Biol       Date:  2015-09-02       Impact factor: 5.100

Review 9.  Harnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease.

Authors:  Arun K Ghosh
Journal:  J Med Chem       Date:  2009-04-23       Impact factor: 7.446

10.  Design of HIV-1 protease inhibitors with pyrrolidinones and oxazolidinones as novel P1'-ligands to enhance backbone-binding interactions with protease: synthesis, biological evaluation, and protein-ligand X-ray studies.

Authors:  Arun K Ghosh; Sofiya Leshchenko-Yashchuk; David D Anderson; Abigail Baldridge; Marcus Noetzel; Heather B Miller; Yunfeng Tie; Yuan-Fang Wang; Yasuhiro Koh; Irene T Weber; Hiroaki Mitsuya
Journal:  J Med Chem       Date:  2009-07-09       Impact factor: 7.446
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