Literature DB >> 30443084

Synthesis of Bioactive Natural Products by Asymmetric syn- and anti-Aldol Reactions.

Arun K Ghosh1, Zachary L Dawson1.   

Abstract

The use of several variants of the asymmetric aldol reaction as key steps in the syntheses of bioactive target molecules is described.

Entities:  

Keywords:  anti-aldol; asymmetric synthesis; chiral auxiliary; indanolamine; natural products; syn-aldol

Year:  2009        PMID： 30443084      PMCID： PMC6233898          DOI： 10.1055/s-0029-1216941

Source DB:  PubMed          Journal:  Synthesis (Stuttg)        ISSN： 0039-7881            Impact factor:   3.157


  49 in total

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2.  Stereoselective synthesis of the C(1)-C(11) fragment of peloruside A.

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4.  Highly Enantioselective Aldol Reaction: Development of a New Chiral Auxiliary from cis-1-Amino-2-hydroxyindan.

Authors:  Arun K Ghosh; Tien T Duong; Sean P McKee
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6.  A Convergent, Enantioselective Total Synthesis of Hapalosin: A Drug with Multidrug-Resistance Reversing Activity.

Authors:  Arun K Ghosh; Wenming Liu; Yibo Xu; Zhidong Chen
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7.  Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines.

Authors:  N Kartner; J R Riordan; V Ling
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8.  The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase.

Authors:  P Hadváry; W Sidler; W Meister; W Vetter; H Wolfer
Journal:  J Biol Chem       Date:  1991-02-05       Impact factor: 5.157

9.  Cryptophycin: a new antimicrotubule agent active against drug-resistant cells.

Authors:  C D Smith; X Zhang; S L Mooberry; G M Patterson; R E Moore
Journal:  Cancer Res       Date:  1994-07-15       Impact factor: 12.701

10.  1H-2-Benzopyran-1-one derivatives, microbial products with pharmacological activity. Conversion into orally active derivatives with antiinflammatory and antiulcer activities.

Authors:  Y Shimojima; T Shirai; T Baba; H Hayashi
Journal:  J Med Chem       Date:  1985-01       Impact factor: 7.446
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  2 in total

1.  Catalytic Reductive Aldol and Mannich Reactions of Enone, Acrylate, and Vinyl Heteroaromatic Pronucleophiles.

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2.  Highly Stereoselective Asymmetric Aldol Routes to tert-Butyl-2-(3,5-difluorophenyl)-1-oxiran-2-yl)ethyl)carbamates: Building Blocks for Novel Protease Inhibitors.

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  2 in total

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