Literature DB >> 20936876

Capturing the essence of organic synthesis: from bioactive natural products to designed molecules in today's medicine.

Arun K Ghosh1.   

Abstract

In this Perspective, I outline my group's research involving the chemical syntheses of medicinally important natural products, exploration of their bioactivity, and the development of new asymmetric carbon-carbon bond-forming reactions. This paper also highlights our approach to molecular design and synthesis of conceptually novel inhibitors against target proteins involved in the pathogenesis of human diseases, including AIDS and Alzheimer's disease.

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Year:  2010        PMID： 20936876      PMCID： PMC2993809          DOI： 10.1021/jo101606g

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  108 in total

1.  A Convergent, Enantioselective Total Synthesis of Streptogramin Antibiotic (-)-Madumycin II.

Authors:  Arun K. Ghosh; Wenming Liu
Journal:  J Org Chem       Date:  1997-11-14       Impact factor: 4.354

2.  Counterions of BINAP-Pt(II) and -Pd(II) complexes: novel catalysts for highly enantioselective Diels-Alder reaction.

Authors:  A K Ghosh; H Matsuda
Journal:  Org Lett       Date:  1999-12-30       Impact factor: 6.005

3.  Biosynthetic studies of platensimycin.

Authors:  Kithsiri B Herath; Athula B Attygalle; Sheo B Singh
Journal:  J Am Chem Soc       Date:  2007-11-23       Impact factor: 15.419

4.  Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.

Authors:  A K Ghosh; J F Kincaid; W Cho; D E Walters; K Krishnan; K A Hussain; Y Koo; H Cho; C Rudall; L Holland; J Buthod
Journal:  Bioorg Med Chem Lett       Date:  1998-03-17       Impact factor: 2.823

5.  Platensimycin is a selective FabF inhibitor with potent antibiotic properties.

Authors:  Jun Wang; Stephen M Soisson; Katherine Young; Wesley Shoop; Srinivas Kodali; Andrew Galgoci; Ronald Painter; Gopalakrishnan Parthasarathy; Yui S Tang; Richard Cummings; Sookhee Ha; Karen Dorso; Mary Motyl; Hiranthi Jayasuriya; John Ondeyka; Kithsiri Herath; Chaowei Zhang; Lorraine Hernandez; John Allocco; Angela Basilio; José R Tormo; Olga Genilloud; Francisca Vicente; Fernando Pelaez; Lawrence Colwell; Sang Ho Lee; Bruce Michael; Thomas Felcetto; Charles Gill; Lynn L Silver; Jeffery D Hermes; Ken Bartizal; John Barrett; Dennis Schmatz; Joseph W Becker; Doris Cully; Sheo B Singh
Journal:  Nature       Date:  2006-05-18       Impact factor: 49.962

6.  Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: isolation, structure, total synthesis, and bioactivity.

Authors:  A Jonathan Singh; Chun-Xiao Xu; Xiaoming Xu; Lyndon M West; Anja Wilmes; Ariane Chan; Ernest Hamel; John H Miller; Peter T Northcote; Arun K Ghosh
Journal:  J Org Chem       Date:  2010-01-01       Impact factor: 4.354

7.  Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents.

Authors:  S L Mooberry; G Tien; A H Hernandez; A Plubrukarn; B S Davidson
Journal:  Cancer Res       Date:  1999-02-01       Impact factor: 12.701

8.  Cryptophycin: a new antimicrotubule agent active against drug-resistant cells.

Authors:  C D Smith; X Zhang; S L Mooberry; G M Patterson; R E Moore
Journal:  Cancer Res       Date:  1994-07-15       Impact factor: 12.701

Review 9.  Memapsin 2 (beta-secretase) inhibitors: drug development.

Authors:  Arun K Ghosh; Nagaswamy Kumaragurubaran; Ling Hong; Gerald Koelsh; Jordan Tang
Journal:  Curr Alzheimer Res       Date:  2008-04       Impact factor: 3.498

10.  Iriomoteolide-1a, a potent cytotoxic 20-membered macrolide from a benthic dinoflagellate amphidinium species.

Authors:  Masashi Tsuda; Keiko Oguchi; Rie Iwamoto; Yumiko Okamoto; Jun'ichi Kobayashi; Eri Fukushi; Jun Kawabata; Tomoko Ozawa; Atsunori Masuda; Yoshiaki Kitaya; Kenji Omasa
Journal:  J Org Chem       Date:  2007-05-15       Impact factor: 4.354
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  4 in total

1.  Cu(II)-catalyzed olefin migration and Prins cyclization: highly diastereoselective synthesis of substituted tetrahydropyrans.

Authors:  Arun K Ghosh; Daniel R Nicponski
Journal:  Org Lett       Date:  2011-07-28       Impact factor: 6.005

2.  Addressing Structural Flexibility at the A-Ring on Salvinorin A: Discovery of a Potent Kappa-Opioid Agonist with Enhanced Metabolic Stability.

Authors:  Alexander M Sherwood; Rachel Saylor Crowley; Kelly F Paton; Andrew Biggerstaff; Benjamin Neuenswander; Victor W Day; Bronwyn M Kivell; Thomas E Prisinzano
Journal:  J Med Chem       Date:  2017-04-19       Impact factor: 7.446

3.  Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV-1 Protease Inhibitors.

Authors:  Arun K Ghosh; Margherita Brindisi
Journal:  Asian J Org Chem       Date:  2018-06-08       Impact factor: 3.319

4.  Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.

Authors:  Arun K Ghosh; Margherita Brindisi; Prasanth R Nyalapatla; Jun Takayama; Jean-Rene Ella-Menye; Sofiya Yashchuk; Johnson Agniswamy; Yuan-Fang Wang; Manabu Aoki; Masayuki Amano; Irene T Weber; Hiroaki Mitsuya
Journal:  Bioorg Med Chem       Date:  2017-04-09       Impact factor: 3.641
  4 in total

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