Literature DB >> 1132317

[Inhibition of pentagastrin-induced gastric-acid secretion by somatostatin in man (author's transl)].

R Arnold, W Creutzfeldt.   

Abstract

The effect of somatostatin on pentagastrin-induced gastric-acid secretion was measured in three healthy volunteers and four patients with duodenal ulcer. Somatostatin (100, 200 and 400 mug/h) inhibited secretory volume and acid concentration simulated by pentagastrin infusion (2 mug/kg - h), the effect being dose-dependent. In the patients with duodenal ulcer somatostatin given as a bolus (50 mug) and by subsequent infusion (150 mug/h) reduced maximal acid output after subcutaneous injection of 2.0 mug/kg pentagastrin by 68-96%.

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Year:  1975        PMID： 1132317

Source DB:  PubMed          Journal:  Dtsch Med Wochenschr        ISSN： 0012-0472            Impact factor:   0.628


  10 in total

1.  Immuno-fluorescent reactivity to anti-somatostatin in the gastro-intestinal mucosa of the dog.

Authors:  C Rufener; M P Dubois; F Malaisse Lagae; L Oric
Journal:  Diabetologia       Date:  1975-08       Impact factor: 10.122

2.  Effect of somatostatin on meal-induced gastric secretion in duodenal ulcer patients.

Authors:  S J Konturek; J Swierczek; N Kwiecień; E Mikoś; J Oleksy; Z Wierzbicki
Journal:  Am J Dig Dis       Date:  1977-11

3.  Comparison of the inhibition of histamine- and pentagastrin-stimulated gastric acid secretion by somatostatin in the cat.

Authors:  M Albinus; J D Reed; A Gomez-Pan; A V Schally; D H Coy
Journal:  Agents Actions       Date:  1977-12

4.  [Somatostatin -- a review (author's transl)].

Authors:  C Lucke; H J Mitzkat; A von zur Mühlen
Journal:  Klin Wochenschr       Date:  1976-04-01

5.  Topography of somatostatin cells in the stomach of the rat: possible functional significance.

Authors:  J Alumets; M Ekelund; H A El Munshid; R Håkanson; I Lorén; F Sundler
Journal:  Cell Tissue Res       Date:  1979-11       Impact factor: 5.249

6.  Prevention of stress ulcer by somatostatin in rats.

Authors:  P Mattes; H H Lauterbach; S Raptis
Journal:  Langenbecks Arch Chir       Date:  1976-11-12

7.  Effect of intravenous infusion of somatostatin on gastric, pancreatic and biliary secretion in the rat.

Authors:  M Moriga; K Kojima; M Aono; H Uchino; H Yajima
Journal:  Gastroenterol Jpn       Date:  1978

8.  Inhibition by somatostatin (growth-hormone release-inhibiting hormone, GH-RIH) of gastric acid and pepsin and G-cell release of gastrin.

Authors:  A A Barros D'sa; S R Bloom; J H Baron
Journal:  Gut       Date:  1978-04       Impact factor: 23.059

9.  Gastrointestinal somatostatin: extraction and radioimmunoassay in different species.

Authors:  C McIntosh; R Arnold; E Bothe; H Becker; J Köbberling; W Creutzfeldt
Journal:  Gut       Date:  1978-07       Impact factor: 23.059

10.  Prevention of stress ulcer by cimetidine and somatostatin in rats.

Authors:  R Vara-Thorbeck; C Garcia-Blanque; A Villen
Journal:  Langenbecks Arch Chir       Date:  1980
  10 in total

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