Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Two efflux systems expressed simultaneously in multidrug-resistant Pseudomonas aeruginosa.

Literature DB >> 10991874

Two efflux systems expressed simultaneously in multidrug-resistant Pseudomonas aeruginosa.

Abstract

Simultaneous overexpression of MexAB-OprM and MexEF-OprN was demonstrated for a multiply antibiotic-resistant clinical isolate of Pseudomonas aeruginosa (G49). G49 also had decreased expression of OprF. No mutations in mexR or its upstream promoter region, mexT, oprM, oprF, or sigX were revealed, suggesting regulation by a hitherto undescribed locus.

Entities: Species

Mesh：

Substances：

Year: 2000 PMID： 10991874 PMCID： PMC90165 DOI： 10.1128/AAC.44.10.2861-2864.2000

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

24 in total

1. A pleiotropic, posttherapy, enoxacin-resistant mutant of Pseudomonas aeruginosa.

Authors: L J Piddock; M C Hall; F Bellido; M Bains; R E Hancock
Journal: Antimicrob Agents Chemother Date: 1992-05 Impact factor: 5.191

2. marA locus causes decreased expression of OmpF porin in multiple-antibiotic-resistant (Mar) mutants of Escherichia coli.

Authors: S P Cohen; L M McMurry; S B Levy
Journal: J Bacteriol Date: 1988-12 Impact factor: 3.490

3. Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides.

Authors: J R Aires; T Köhler; H Nikaido; P Plésiat
Journal: Antimicrob Agents Chemother Date: 1999-11 Impact factor: 5.191

4. Quinolone/ureidopenicillin cross-resistance.

Authors: L J Piddock; W J Wijnands; R Wise
Journal: Lancet Date: 1987-10-17 Impact factor: 79.321

5. The accumulation of five antibacterial agents in porin-deficient mutants of Escherichia coli.

Authors: P G Mortimer; L J Piddock
Journal: J Antimicrob Chemother Date: 1993-08 Impact factor: 5.790

6. A rapid and versatile method to synthesize internal standards for competitive PCR.

Authors: F S Celi; M E Zenilman; A R Shuldiner
Journal: Nucleic Acids Res Date: 1993-02-25 Impact factor: 16.971

7. The outer membrane protein OprM of Pseudomonas aeruginosa is encoded by oprK of the mexA-mexB-oprK multidrug resistance operon.

Authors: N Gotoh; H Tsujimoto; K Poole; J Yamagishi; T Nishino
Journal: Antimicrob Agents Chemother Date: 1995-11 Impact factor: 5.191

8. nalB-type mutations causing the overexpression of the MexAB-OprM efflux pump are located in the mexR gene of the Pseudomonas aeruginosa chromosome.

Authors: K Saito; H Yoneyama; T Nakae
Journal: FEMS Microbiol Lett Date: 1999-10-01 Impact factor: 2.742

9. Role of gyrA mutation and loss of OprF in the multiple antibiotic resistance phenotype of Pseudomonas aeruginosa G49.

Authors: L Pumbwe; M J Everett; R E Hancock; L J Piddock
Journal: FEMS Microbiol Lett Date: 1996-09-15 Impact factor: 2.742

10. Purification of a 54-kilodalton protein (OprJ) produced in NfxB mutants of Pseudomonas aeruginosa and production of a monoclonal antibody specific to OprJ.

Authors: M Hosaka; N Gotoh; T Nishino
Journal: Antimicrob Agents Chemother Date: 1995-08 Impact factor: 5.191

25 in total

1. Clinical strains of Pseudomonas aeruginosa overproducing MexAB-OprM and MexXY efflux pumps simultaneously.

Authors: Catherine Llanes; Didier Hocquet; Christelle Vogne; Dounia Benali-Baitich; Catherine Neuwirth; Patrick Plésiat
Journal: Antimicrob Agents Chemother Date: 2004-05 Impact factor: 5.191

2. Amino Acid Substitutions Account for Most MexS Alterations in Clinical nfxC Mutants of Pseudomonas aeruginosa.

Authors: Charlotte Richardot; Paulo Juarez; Katy Jeannot; Isabelle Patry; Patrick Plésiat; Catherine Llanes
Journal: Antimicrob Agents Chemother Date: 2016-03-25 Impact factor: 5.191

Review 3. Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria.

Authors: Laura J V Piddock
Journal: Clin Microbiol Rev Date: 2006-04 Impact factor: 26.132

Review 4. Molecular mechanisms of antibiotic resistance.

Authors: Jessica M A Blair; Mark A Webber; Alison J Baylay; David O Ogbolu; Laura J V Piddock
Journal: Nat Rev Microbiol Date: 2014-12-01 Impact factor: 60.633

Review 5. The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Authors: Xian-Zhi Li; Patrick Plésiat; Hiroshi Nikaido
Journal: Clin Microbiol Rev Date: 2015-04 Impact factor: 26.132

6. Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It.

Authors: Helen I Zgurskaya; Cesar A Löpez; S Gnanakaran
Journal: ACS Infect Dis Date: 2015 Impact factor: 5.084

7. Reverse engineering antibiotic sensitivity in a multidrug-resistant Pseudomonas aeruginosa isolate.

Authors: Julie M Struble; Ryan T Gill
Journal: Antimicrob Agents Chemother Date: 2006-07 Impact factor: 5.191

8. Absence of mutations in marRAB or soxRS in acrB-overexpressing fluoroquinolone-resistant clinical and veterinary isolates of Escherichia coli.

Authors: M A Webber; L J Piddock
Journal: Antimicrob Agents Chemother Date: 2001-05 Impact factor: 5.191

9. Role of the MexEF-OprN efflux system in low-level resistance of Pseudomonas aeruginosa to ciprofloxacin.

Authors: Catherine Llanes; Thilo Köhler; Isabelle Patry; Barbara Dehecq; Christian van Delden; Patrick Plésiat
Journal: Antimicrob Agents Chemother Date: 2011-09-12 Impact factor: 5.191

10. Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa.

Authors: Juan F Linares; Juan A López; Emilio Camafeita; Juan P Albar; Fernando Rojo; Jose L Martínez
Journal: J Bacteriol Date: 2005-02 Impact factor: 3.490