Literature DB >> 16189130

Contribution of mutation at amino acid 45 of AcrR to acrB expression and ciprofloxacin resistance in clinical and veterinary Escherichia coli isolates.

Mark A Webber1, Ashraf Talukder, Laura J V Piddock.   

Abstract

Fluoroquinolone-resistant Escherichia coli isolates which overexpressed acrB and had a substitution at amino acid 45 of AcrR were complemented with wild-type acrR. Complementation led to increased sensitivity to ciprofloxacin and to ethidium bromide, suggesting that mutation at amino acid 45 of AcrR contributes to ciprofloxacin resistance.

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Year:  2005        PMID： 16189130      PMCID： PMC1251554          DOI： 10.1128/AAC.49.10.4390-4392.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

Review 1.  The mar regulon: multiple resistance to antibiotics and other toxic chemicals.

Authors:  M N Alekshun; S B Levy
Journal:  Trends Microbiol       Date:  1999-10       Impact factor: 17.079

2.  Determination of minimum inhibitory concentrations.

Authors:  J M Andrews
Journal:  J Antimicrob Chemother       Date:  2001-07       Impact factor: 5.790

3.  Absence of mutations in marRAB or soxRS in acrB-overexpressing fluoroquinolone-resistant clinical and veterinary isolates of Escherichia coli.

Authors:  M A Webber; L J Piddock
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

4.  Genetic characterization of highly fluoroquinolone-resistant clinical Escherichia coli strains from China: role of acrR mutations.

Authors:  H Wang; J L Dzink-Fox; M Chen; S B Levy
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

5.  Increased expression of the multidrug efflux genes acrAB occurs during slow growth of Escherichia coli.

Authors:  Jonathan D Rand; Simon G Danby; David L A Greenway; Reg R England
Journal:  FEMS Microbiol Lett       Date:  2002-01-22       Impact factor: 2.742

6.  AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants.

Authors:  H Okusu; D Ma; H Nikaido
Journal:  J Bacteriol       Date:  1996-01       Impact factor: 3.490

7.  Role of an acrR mutation in multidrug resistance of in vitro-selected fluoroquinolone-resistant mutants of Salmonella enterica serovar Typhimurium.

Authors:  Anne Olliver; Michel Vallé; Elisabeth Chaslus-Dancla; Axel Cloeckaert
Journal:  FEMS Microbiol Lett       Date:  2004-09-01       Impact factor: 2.742

8.  Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.

Authors:  T Schneiders; S G B Amyes; S B Levy
Journal:  Antimicrob Agents Chemother       Date:  2003-09       Impact factor: 5.191

9.  The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signals.

Authors:  D Ma; M Alberti; C Lynch; H Nikaido; J E Hearst
Journal:  Mol Microbiol       Date:  1996-01       Impact factor: 3.501

10.  Amplifiable resistance to tetracycline, chloramphenicol, and other antibiotics in Escherichia coli: involvement of a non-plasmid-determined efflux of tetracycline.

Authors:  A M George; S B Levy
Journal:  J Bacteriol       Date:  1983-08       Impact factor: 3.490
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  23 in total

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Authors:  Laura J V Piddock
Journal:  Clin Microbiol Rev       Date:  2006-04       Impact factor: 26.132

Review 2.  Molecular mechanisms of antibiotic resistance.

Authors:  Jessica M A Blair; Mark A Webber; Alison J Baylay; David O Ogbolu; Laura J V Piddock
Journal:  Nat Rev Microbiol       Date:  2014-12-01       Impact factor: 60.633

3.  Mechanisms of fluoroquinolone resistance in Escherichia coli isolates from food-producing animals.

Authors:  Maria Karczmarczyk; Marta Martins; Teresa Quinn; Nola Leonard; Séamus Fanning
Journal:  Appl Environ Microbiol       Date:  2011-08-19       Impact factor: 4.792

4.  AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity.

Authors:  Jessica M A Blair; Vassiliy N Bavro; Vito Ricci; Niraj Modi; Pierpaolo Cacciotto; Ulrich Kleinekathӧfer; Paolo Ruggerone; Attilio V Vargiu; Alison J Baylay; Helen E Smith; Yvonne Brandon; David Galloway; Laura J V Piddock
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-03       Impact factor: 11.205

5.  Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria.

Authors:  Ilyas Alav; Jessica Kobylka; Miriam S Kuth; Klaas M Pos; Martin Picard; Jessica M A Blair; Vassiliy N Bavro
Journal:  Chem Rev       Date:  2021-04-28       Impact factor: 60.622

Review 6.  Efflux pumps of the resistance-nodulation-division family: a perspective of their structure, function, and regulation in gram-negative bacteria.

Authors:  Mathew D Routh; Yaramah Zalucki; Chih-Chia Su; Qijing Zhang; William M Shafer; Edward W Yu
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  2011

7.  In vitro selection of ramR and soxR mutants overexpressing efflux systems by fluoroquinolones as well as cefoxitin in Klebsiella pneumoniae.

Authors:  Suzanne Bialek-Davenet; Estelle Marcon; Véronique Leflon-Guibout; Jean-Philippe Lavigne; Frédéric Bert; Richard Moreau; Marie-Hélène Nicolas-Chanoine
Journal:  Antimicrob Agents Chemother       Date:  2011-04-04       Impact factor: 5.191

8.  Inducible Expression of a Resistance-Nodulation-Division-Type Efflux Pump in Staphylococcus aureus Provides Resistance to Linoleic and Arachidonic Acids.

Authors:  Heba Alnaseri; Benjamin Arsic; James E T Schneider; Julienne C Kaiser; Zachariah C Scinocca; David E Heinrichs; Martin J McGavin
Journal:  J Bacteriol       Date:  2015-03-23       Impact factor: 3.490

9.  Constitutive SoxS expression in a fluoroquinolone-resistant strain with a truncated SoxR protein and identification of a new member of the marA-soxS-rob regulon, mdtG.

Authors:  Anna Fàbrega; Robert G Martin; Judah L Rosner; M Mar Tavio; Jordi Vila
Journal:  Antimicrob Agents Chemother       Date:  2009-12-14       Impact factor: 5.191

10.  Whole-Genome Sequencing and Genetic Analysis Reveal Novel Stress Responses to Individual Constituents of Essential Oils in Escherichia coli.

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Journal:  Appl Environ Microbiol       Date:  2018-03-19       Impact factor: 4.792
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