Literature DB >> 11283588

The potential of nucleic acid repair in functional genomics.

M C Rice1, K Czymmek, E B Kmiec.   

Abstract

Chimeric RNA/DNA oligonucleotides have been used successfully to correct point and frameshift mutations in cells as well as in animal and plant models. This approach is one of several nucleic acid repair technologies that will help elucidate the function of newly discovered genes. Understanding the mechanisms by which these different technologies direct gene alteration is essential for progress in their application to functional genomics.

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Year:  2001        PMID： 11283588     DOI： 10.1038/86701

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


  12 in total

1.  Quantitative assessment of chimeraplast stability in biological fluids by polyacrylamide gel electrophoresis and laser-assisted fluorescence analysis.

Authors:  David de Semir; Anna Avinyó; Sara Larriba; Virginia Nunes; Teresa Casals; Xavier Estivill; Josep M Aran
Journal:  Pharm Res       Date:  2002-06       Impact factor: 4.200

2.  Transcription affects formation and processing of intermediates in oligonucleotide-mediated gene alteration.

Authors:  Olga Igoucheva; Vitali Alexeev; Melissa Pryce; Kyonggeun Yoon
Journal:  Nucleic Acids Res       Date:  2003-05-15       Impact factor: 16.971

Review 3.  Targeted gene repair -- in the arena.

Authors:  Eric B Kmiec
Journal:  J Clin Invest       Date:  2003-09       Impact factor: 14.808

4.  Reaction parameters of targeted gene repair in mammalian cells.

Authors:  Yiling Hu; Hetal Parekh-Olmedo; Miya Drury; Michael Skogen; Eric B Kmiec
Journal:  Mol Biotechnol       Date:  2005-03       Impact factor: 2.695

5.  Correction of the neuropathogenic human apolipoprotein E4 (APOE4) gene to APOE3 in vitro using synthetic RNA/DNA oligonucleotides (chimeraplasts).

Authors:  Aristides D Tagalakis; J George Dickson; James S Owen; J Paul Simons
Journal:  J Mol Neurosci       Date:  2005       Impact factor: 3.444

Review 6.  Gene replacement by homologous recombination in plants.

Authors:  Holger Puchta
Journal:  Plant Mol Biol       Date:  2002-01       Impact factor: 4.076

7.  Oligonucleotide-directed gene repair in wheat using a transient plasmid gene repair assay system.

Authors:  Chongmei Dong; Peter Beetham; Kate Vincent; Peter Sharp
Journal:  Plant Cell Rep       Date:  2006-01-11       Impact factor: 4.570

8.  In vivo gene repair of point and frameshift mutations directed by chimeric RNA/DNA oligonucleotides and modified single-stranded oligonucleotides.

Authors:  L Liu; M C Rice; E B Kmiec
Journal:  Nucleic Acids Res       Date:  2001-10-15       Impact factor: 16.971

9.  Short tetracysteine tags to beta-tubulin demonstrate the significance of small labels for live cell imaging.

Authors:  Martin Andresen; Rita Schmitz-Salue; Stefan Jakobs
Journal:  Mol Biol Cell       Date:  2004-10-06       Impact factor: 4.138

10.  Rad51p and Rad54p, but not Rad52p, elevate gene repair in Saccharomyces cerevisiae directed by modified single-stranded oligonucleotide vectors.

Authors:  Li Liu; Shuqiu Cheng; Anja J van Brabant; Eric B Kmiec
Journal:  Nucleic Acids Res       Date:  2002-07-01       Impact factor: 16.971
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