Literature DB >> 1123977

Inhibition of enzymatic reduction of delta 14-double bond of 5 alpha-cholesta-8,14-dien-3 beta-ol and 5 alpha-cholesta-7,14-dien-3 beta-ol by AY-9944.

B N Lutsky, H M Hsiung, G J Schroepfer.   

Abstract

AY-994 (trans-1,4-bis-(2-chlorobenzyl-aminomethyl) cyclohexane dihydrochloride), a potent inhibitor of the enzymatic reduction of the delta 7-double bond of delta 5,7-sterols, has been shown to inhibit, at higher concentrations (10-4 M), the enzymatic reduction of the delta 14-double bond of cholesta-8,14-dien-3 beta-ol and cholesta-7,14-dien-3 beta-ol.

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Year:  1975        PMID： 1123977     DOI： 10.1007/bf02532186

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  11 in total

Review 1.  Recent investigations on the nature of sterol intermediates in the biosynthesis of cholesterol.

Authors:  G J Schroepfer; B N Lutsky; J A Martin; S Huntoon; B Fourcans; W H Lee; J Vermilion
Journal:  Proc R Soc Lond B Biol Sci       Date:  1972-02-15

2.  Stereospecificity in the enzymatic conversion of delta-7-cholesten-3-beta-ol to 7-dehydrocholesterol.

Authors:  A M Paliokas; G J Schroepfer
Journal:  J Biol Chem       Date:  1968-02-10       Impact factor: 5.157

3.  Evidence for the biological conversion of delta 8,14 sterol dienes into cholesterol.

Authors:  L Canonica; A Fiecchi; M G Kienle; A Scala; G Galli; E G Paoletti; R Paoletti
Journal:  J Am Chem Soc       Date:  1968-11-06       Impact factor: 15.419

4.  Studies on the enzymatic conversion of 5 alpha-cholesta-8, 14-dien-3 beta-ol to cholesterol.

Authors:  B N Lutsky; G J Schroepfer
Journal:  J Biol Chem       Date:  1970-12-10       Impact factor: 5.157

5.  Enzymatic conversion of delta8, 14-cholestadien-3beta-ol to cholesterol.

Authors:  B N Lutsky; G J Schroepfer
Journal:  Biochem Biophys Res Commun       Date:  1968-11-08       Impact factor: 3.575

6.  Agents affecting lipid metabolism. 28. A 7-dehydrocholesterol delta-7-reductase inhibitor (AY-9944) as tool in studies of delta-7-sterol metabolism.

Authors:  D Dvornik; M Kraml; J F Bagli
Journal:  Biochemistry       Date:  1966-03       Impact factor: 3.162

7.  The stereochemistry of hydrogen transfer from reduced nicotinamide-adenine dinucleotide phosphate in the reduction of ethylenic linkages during cholesterol biosynthesis.

Authors:  D C Wilton; I A Watkinson; M Akhtar
Journal:  Biochem J       Date:  1970-10       Impact factor: 3.857

8.  Enzymatic conversion of 5alpha-cholest-8(14)-en-3beta-o1 to 5alpha-cholesta-8,14-dien-3beta-o1.

Authors:  B N Lutsky; G J Schroepfer
Journal:  Lipids       Date:  1971-12       Impact factor: 1.880

9.  Studies on the mechanism of the enzymatic conversion of delta 8-cholesten-3 beta-ol to delta 7-cholesten-3 beta-ol.

Authors:  W H Lee; R Kammereck; B N Lutsky; J A McCloskey; G J Schroepfer
Journal:  J Biol Chem       Date:  1969-04-25       Impact factor: 5.157

10.  Studies of the metabolism of 5 -cholesta-8,14-dien-3 -ol and 5 -cholesta-7,14-dien-3 -ol in rat liver homogenate preparations.

Authors:  B N Lutsky; J A Martin; G J Schroepfer
Journal:  J Biol Chem       Date:  1971-11-25       Impact factor: 5.157
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  2 in total

1.  Enzymatic conversion of 5alpha-cholesta-7, 14-dien-3beta-ol to 5alpha-cholesta-8, 14-dien-3beta-ol.

Authors:  H M Hsiung; T E Spike; G J Schroepfer
Journal:  Lipids       Date:  1975-10       Impact factor: 1.880

2.  Accumulation of ergosta-8,14-dien-3beta-ol by Saccharomyces cerevisiae cultured with an azasterol antimycotic agent.

Authors:  P R Hays; L W Parks; H D Pierce; A C Oehlschlager
Journal:  Lipids       Date:  1977-08       Impact factor: 1.880
  2 in total

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