Literature DB >> 4395428

The stereochemistry of hydrogen transfer from reduced nicotinamide-adenine dinucleotide phosphate in the reduction of ethylenic linkages during cholesterol biosynthesis.

D C Wilton, I A Watkinson, M Akhtar.   

Abstract

It is shown that during the saturation of steroid carbon-carbon double bonds at Delta(24,25) and Delta(14,15) the ;hydride ion' originates from the 4B side of the NADPH.

Entities:  

Mesh：

Substances：

Year:  1970        PMID： 4395428      PMCID： PMC1179453          DOI： 10.1042/bj1190673

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  5 in total

1.  The biological conversion of 7-dehydrocholesterol into cholesterol and comments on the reduction of double bonds.

Authors:  D C Wilton; K A Munday; S J Skinner; M Akhtar
Journal:  Biochem J       Date:  1968-02       Impact factor: 3.857

2.  Trans reduction of delta24 of lanosterol in the biosynthesis of cholesterol by rat liver enzymes.

Authors:  E Caspi; M G Kienle; K R Varma; L J Mulheirn
Journal:  J Am Chem Soc       Date:  1970-04-08       Impact factor: 15.419

3.  The status of C-6, C-7, C-15 and C-16 hydrogen atoms in cholesterol biosynthesis.

Authors:  M Akhtar; A D Rahimtula; I A Watkinson; D C Wilton; K A Munday
Journal:  Eur J Biochem       Date:  1969-05-01

4.  Mechamism and stereochemistry of the enzymatic conversion of a delta 4-3-oxosteroid into a 3-oxo-5alpha-steroid.

Authors:  I Björkhem
Journal:  Eur J Biochem       Date:  1969-04

5.  Enzymatic conversion of a delta-4-3-ketosteroid into a 3-alpha-hydroxy-5-beta steroid: mechanism and stereochemistry of hydrogen transfer from NADPH. Bile acids and steroids 190.

Authors:  O Berséus; L Björkhem
Journal:  Eur J Biochem       Date:  1967-11
  5 in total
  4 in total

1.  4,4'-dimethylcholesta-7,9,14-trienol is an intermediate in the demethylation of dihydroagnosterol.

Authors:  I A Tavares; K A Munday; D C Wilton
Journal:  Biochem J       Date:  1977-07-15       Impact factor: 3.857

2.  Inhibition of enzymatic reduction of delta 14-double bond of 5 alpha-cholesta-8,14-dien-3 beta-ol and 5 alpha-cholesta-7,14-dien-3 beta-ol by AY-9944.

Authors:  B N Lutsky; H M Hsiung; G J Schroepfer
Journal:  Lipids       Date:  1975-01       Impact factor: 1.880

3.  The formation and reduction of the 14,15-double bond in cholesterol biosynthesis.

Authors:  I A Watkinson; D C Wilton; K A Munday; M Akhtar
Journal:  Biochem J       Date:  1971-01       Impact factor: 3.857

4.  Studies on the mechanism and regulation of C-4 demethylation in cholesterol biosynthesis. The role of adenosine 3':5'-cyclic monophosphate.

Authors:  D P Bloxham; D C Wilton; M Akhtar
Journal:  Biochem J       Date:  1971-11       Impact factor: 3.857
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.