Literature DB >> 1186448

Enzymatic conversion of 5alpha-cholesta-7, 14-dien-3beta-ol to 5alpha-cholesta-8, 14-dien-3beta-ol.

H M Hsiung, T E Spike, G J Schroepfer.   

Abstract

5alpha-Cholesta-7, 14-dien-3beta-ol, previously shown to be efficiently converted to cholesterol upon incubation with rat liver homogenate preparations under aerobic conditions, has been studied as to its possible conversion to 5alpha-cholesta-8, 14-dien-3beta-ol. Efficient conversion was observed upon incubation in the presence of washed mictosomes of rat liver under anaerobic conditions. This observation is of importance in consideration of possible metabolic pathways in the biosythesis of cholesterol.

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 1186448     DOI： 10.1007/bf02532727

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  13 in total

1.  THE SKIN STEROLS OF NORMAL AND TRIPARANOL-TREATED RATS.

Authors:  R B CLAYTON; A N NELSON; I D FRANTZ
Journal:  J Lipid Res       Date:  1963-04       Impact factor: 5.922

2.  Biosynthesis of skin sterols. V. Effect of arsenite inhibition and the accumulation of labeled lanosta-7, 24-dien-3 beta-ol in rat skin.

Authors:  J L GAYLOR
Journal:  Arch Biochem Biophys       Date:  1963-06       Impact factor: 4.013

3.  Biosynthesis of skin sterols. IV. Identification of labeled lanosta-7, 24-dien-3 beta-ol from rat skin.

Authors:  J L GAYLOR
Journal:  J Biol Chem       Date:  1963-05       Impact factor: 5.157

Review 4.  Recent investigations on the nature of sterol intermediates in the biosynthesis of cholesterol.

Authors:  G J Schroepfer; B N Lutsky; J A Martin; S Huntoon; B Fourcans; W H Lee; J Vermilion
Journal:  Proc R Soc Lond B Biol Sci       Date:  1972-02-15

5.  Stereospecificity in the enzymatic conversion of delta-7-cholesten-3-beta-ol to 7-dehydrocholesterol.

Authors:  A M Paliokas; G J Schroepfer
Journal:  J Biol Chem       Date:  1968-02-10       Impact factor: 5.157

6.  The origin of lanosta-7,24-dienol in rat skin.

Authors:  G M Hornby; G S Boyd
Journal:  Biochem J       Date:  1971-10       Impact factor: 3.857

7.  Studies on the enzymatic conversion of 5 alpha-cholesta-8, 14-dien-3 beta-ol to cholesterol.

Authors:  B N Lutsky; G J Schroepfer
Journal:  J Biol Chem       Date:  1970-12-10       Impact factor: 5.157

8.  Inhibition of enzymatic reduction of delta 14-double bond of 5 alpha-cholesta-8,14-dien-3 beta-ol and 5 alpha-cholesta-7,14-dien-3 beta-ol by AY-9944.

Authors:  B N Lutsky; H M Hsiung; G J Schroepfer
Journal:  Lipids       Date:  1975-01       Impact factor: 1.880

9.  Studies on the mechanism of the enzymatic conversion of delta 8-cholesten-3 beta-ol to delta 7-cholesten-3 beta-ol.

Authors:  W H Lee; R Kammereck; B N Lutsky; J A McCloskey; G J Schroepfer
Journal:  J Biol Chem       Date:  1969-04-25       Impact factor: 5.157

10.  Studies of the metabolism of 5 -cholesta-8,14-dien-3 -ol and 5 -cholesta-7,14-dien-3 -ol in rat liver homogenate preparations.

Authors:  B N Lutsky; J A Martin; G J Schroepfer
Journal:  J Biol Chem       Date:  1971-11-25       Impact factor: 5.157
View more
  1 in total

1.  Silver ion high pressure liquid chromatography provides unprecedented separation of sterols: application to the enzymatic formation of cholesta-5,8-dien-3 beta-ol.

Authors:  B Ruan; J Shey; N Gerst; W K Wilson; G J Schroepfer
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-15       Impact factor: 11.205
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.