Literature DB >> 2552764

The pharmacology of arachidonic acid-induced rat PMN leukocyte infiltration.

M J DiMartino1, C E Wolff, G K Campbell, N Hanna.   

Abstract

Arachidonic Acid (AA) injected into a hindpaw of Lewis rats produces high levels of tissue myeloperoxidase (MPO), a biochemical marker for PMN leukocytes. Treatment with a corticosteroid (prednisolone) or dual 5-LO/CO inhibitors of AA metabolism (phenidone, SKF 86002) produced dose-related inhibition of AA-induced elevations in paw tissue MPO levels. In contrast, administration of high pharmacologic doses of selective cyclooxygenase inhibitors (indomethacin, ibuprofen, naproxen), anti-histamine/serotonin agents (cyproheptadine, chlorpheniramine) or an anti-arthritic gold compound (auranofin) produced only slight or moderate effects. Thus, AA-induced hindpaw inflammation is a useful method for determining pharmacologic effects of 5-LO/CO inhibitors on PMN leukocyte infiltration in vivo.

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Year:  1989        PMID： 2552764     DOI： 10.1007/BF01972812

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  7 in total

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2.  SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.

Authors:  D E Griswold; P J Marshall; E F Webb; R Godfrey; J Newton; M J DiMartino; H M Sarau; J G Gleason; G Poste; N Hanna
Journal:  Biochem Pharmacol       Date:  1987-10-15       Impact factor: 5.858

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Journal:  Lab Invest       Date:  1982-10       Impact factor: 5.662

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Authors:  K Suzuki; H Ota; S Sasagawa; T Sakatani; T Fujikura
Journal:  Anal Biochem       Date:  1983-07-15       Impact factor: 3.365

7.  The pharmacology of arachidonic acid-induced rat paw edema.

Authors:  M J DiMartino; G K Campbell; C E Wolff; N Hanna
Journal:  Agents Actions       Date:  1987-08
  7 in total
  4 in total

1.  Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut.

Authors:  E Kankuri; K Vaali; R Korpela; I Paakkari; H Vapaatalo; E Moilanen
Journal:  Inflammation       Date:  2001-10       Impact factor: 4.092

2.  The role of migrating leukocytes in IL-1 beta-induced up-regulation of kinin B(1) receptors in rats.

Authors:  Maria M Campos; Glória E P de Souza; Natasha D Ricci; Jorge L Pesquero; Mauro M Teixeira; João B Calixto
Journal:  Br J Pharmacol       Date:  2002-03       Impact factor: 8.739

3.  Leukotriene B4-induced granulocyte trafficking in guinea pig dermis. Effect of second-generation leukotriene B4 receptor antagonists, SC-50605 and SC-51146.

Authors:  D J Fretland; D L Widomski; C P Anglin; T D Penning; S Yu; S W Djuric
Journal:  Inflammation       Date:  1993-06       Impact factor: 4.092

4.  Antiinflammatory effects of second-generation leukotriene B4 receptor antagonist, SC-53228: impact upon leukotriene B4- and 12(R)-HETE-mediated events.

Authors:  D J Fretland; C P Anglin; M Bremer; P Isakson; D L Widomski; S K Paulson; S H Docter; S W Djuric; T D Penning; S Yu
Journal:  Inflammation       Date:  1995-04       Impact factor: 4.092
  4 in total

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