Literature DB >> 11175771

Interleukin 12 and autoimmune diabetes.

L Adorini1.   

Abstract

Interleukin 12 (IL-12) has been implicated in the pathogenesis of type 1 diabetes in the non-obese diabetic (NOD) mouse. Following this lead, a new locus associated with human type 1 diabetes, IDDM18, has been identified near the gene encoding the p40 subunit of interleukin 12 (IL12B). This finding has potential implications for the prediction of at-risk individuals and, perhaps, for the implementation of prevention strategies relevant to several autoimmune diseases.

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Year:  2001        PMID： 11175771     DOI： 10.1038/84732

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  12 in total

1.  New autoimmune genes and the pathogenesis of type 1 diabetes.

Authors:  Lars Hornum; Helle Markholst
Journal:  Curr Diab Rep       Date:  2004-04       Impact factor: 4.810

2.  Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats.

Authors:  Swarup K Chakrabarti; Yeshao Wen; Anca D Dobrian; Banumathi K Cole; Qian Ma; Hong Pei; Michael D Williams; Melissa H Bevard; George E Vandenhoff; Susanna R Keller; Jiali Gu; Jerry L Nadler
Journal:  Am J Physiol Endocrinol Metab       Date:  2010-10-26       Impact factor: 4.310

3.  Differential gene expression in pancreatic tissues of streptozocin-induced diabetic rats and genetically-diabetic mice in response to hypoglycemic dipeptide cyclo (His-Pro) treatment.

Authors:  Song Ah Choi; Hyung Joo Suh; Jong Won Yun; Jang Won Choi
Journal:  Mol Biol Rep       Date:  2012-06-17       Impact factor: 2.316

4.  IL18 Gene Polymorphism Influences Age of Onset of DM1 in African Ancestry Brazilians.

Authors:  Alejandro Boëchat-Fernandes; Rosângela Roginski Réa; Nicole Balster Romanzini; Marilia Brito Gomes; Lupe Furtado-Alle; Ricardo L R Souza
Journal:  J Pediatr Genet       Date:  2019-01-30

Review 5.  Nanomedicines for dysfunctional macrophage-associated diseases.

Authors:  Hongliang He; Shobha Ghosh; Hu Yang
Journal:  J Control Release       Date:  2017-01-03       Impact factor: 9.776

Review 6.  Dissecting autoimmune diabetes through genetic manipulation of non-obese diabetic mice.

Authors:  Y Yang; P Santamaria
Journal:  Diabetologia       Date:  2003-10-28       Impact factor: 10.122

7.  12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes.

Authors:  Swarup K Chakrabarti; Banumathi K Cole; Yeshao Wen; Susanna R Keller; Jerry L Nadler
Journal:  Obesity (Silver Spring)       Date:  2009-06-11       Impact factor: 5.002

8.  Elevated levels of serum IL-12 and IL-18 are associated with lower frequencies of CD4(+)CD25 (high)FOXP3 (+) regulatory t cells in young patients with type 1 diabetes.

Authors:  Monika Ryba-Stanisławowska; Karolina Rybarczyk-Kapturska; Małgorzata Myśliwiec; Jolanta Myśliwska
Journal:  Inflammation       Date:  2014-10       Impact factor: 4.092

9.  High Interleukin-12 Levels May Prevent an Increase in the Amount of Fungi in the Gastrointestinal Tract during the First Years of Diabetes Mellitus Type 1.

Authors:  Beata Kowalewska; Katarzyna Zorena; Małgorzata Szmigiero-Kawko; Piotr Wąż; Małgorzata Myśliwiec
Journal:  Dis Markers       Date:  2016-12-29       Impact factor: 3.434

10.  Recombinant Lactococcus lactis Carrying IL-4 and IL-10 Coding Vectors Protects against Type 1 Diabetes in NOD Mice and Attenuates Insulitis in the STZ-Induced Model.

Authors:  Tatiane M Preisser; Vanessa P da Cunha; Mariana P Santana; Vanessa B Pereira; Denise C Cara; Bianca M Souza; Anderson Miyoshi
Journal:  J Diabetes Res       Date:  2021-02-02       Impact factor: 4.011
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