Literature DB >> 30775053

IL18 Gene Polymorphism Influences Age of Onset of DM1 in African Ancestry Brazilians.

Alejandro Boëchat-Fernandes1, Rosângela Roginski Réa2, Nicole Balster Romanzini2, Marilia Brito Gomes3, Lupe Furtado-Alle1, Ricardo L R Souza1.   

Abstract

The aim of this study was to investigate the relationship of two single nucleotide polymorphisms (SNPs) in the interleukin-18 ( IL18 ) gene (rs187238, g.-137G > C; rs1946518, g.-607C > A) and one SNP of the IL12B gene (rs3212227 g.*159A > C, 3'UTR) with the age of onset for type 1 diabetes mellitus (DM1). A total of 1,101 patients with DM1 enrolled in 13 centers from different regions of Brazil were genotyped with TaqMan assay and classified according to the ancestry. Our results show that an SNP in IL18 gene could be associated with DM1 age onset, taking into account that this studied variation affects gene expression.

Entities:  

Keywords:  IL12B; IL18; polymorphism analysis; type 1 diabetes mellitus

Year:  2019        PMID： 30775053      PMCID： PMC6375717          DOI： 10.1055/s-0039-1677749

Source DB:  PubMed          Journal:  J Pediatr Genet        ISSN： 2146-460X


  13 in total

Review 1.  Interleukin 18: a pleiotropic participant in chronic inflammation.

Authors:  I B McInnes; J A Gracie; B P Leung; X Q Wei; F Y Liew
Journal:  Immunol Today       Date:  2000-07

2.  Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1.

Authors:  Masakiyo Nakahira; Hyun-Jong Ahn; Woong-Ryeon Park; Ping Gao; Michio Tomura; Cheung-Seog Park; Toshiyuki Hamaoka; Tsunetaka Ohta; Masashi Kurimoto; Hiromi Fujiwara
Journal:  J Immunol       Date:  2002-02-01       Impact factor: 5.422

Review 3.  Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu.

Authors:  K Nakanishi; T Yoshimoto; H Tsutsui; H Okamura
Journal:  Cytokine Growth Factor Rev       Date:  2001-03       Impact factor: 7.638

4.  Prevalence of adults with type 1 diabetes who meet the goals of care in daily clinical practice: a nationwide multicenter study in Brazil.

Authors:  Marilia B Gomes; Marisa Coral; Roberta A Cobas; Sergio Atala Dib; Luis Henrique Canani; Márcia Nery; Maria Cristina Foss de Freitas; Manuel Faria; João Soares Felício; Saulo Cavalcanti da Silva; Hermelinda Pedrosa; Adriana Costa e Forti; Rosangela Roginski Rea; Antonio Carlos Pires; Renan Montenegro Junior; José Egídio Oliveira; Nelson Rassi; Carlos Antonio Negrato
Journal:  Diabetes Res Clin Pract       Date:  2012-03-06       Impact factor: 5.602

5.  Genetic, autoimmune, and clinical characteristics of childhood- and adult-onset type 1 diabetes.

Authors:  E Sabbah; K Savola; T Ebeling; P Kulmala; P Vähäsalo; J Ilonen; P I Salmela; M Knip
Journal:  Diabetes Care       Date:  2000-09       Impact factor: 19.112

6.  Interleukin 12 and autoimmune diabetes.

Authors:  L Adorini
Journal:  Nat Genet       Date:  2001-02       Impact factor: 38.330

7.  Effects of insulin and glucose on cytokine production from peripheral blood mononuclear cells.

Authors:  Huang-Pin Wu; Chih-Hung Chen; Hul-Chen Hsieh; Yu-Chih Liu
Journal:  Chang Gung Med J       Date:  2008 May-Jun

8.  Polymorphisms in the IL-18 and IL-12B genes and their association with the clinical outcome in Croatian patients with Type 1 diabetes.

Authors:  Marijana Popović Hadžija; Marina Korolija; Nikolina Jemin; Iva Pavković; Pajica Pavković; Edita Pape Medvidović; Mirko Hadžija
Journal:  Gene       Date:  2012-11-06       Impact factor: 3.688

9.  The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age.

Authors:  Jamie R J Inshaw; Neil M Walker; Chris Wallace; Leonardo Bottolo; John A Todd
Journal:  Diabetologia       Date:  2017-10-05       Impact factor: 10.122

10.  Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.

Authors:  Daniel J Perry; Clive H Wasserfall; Richard A Oram; MacKenzie D Williams; Amanda Posgai; Andrew B Muir; Michael J Haller; Desmond A Schatz; Mark A Wallet; Clayton E Mathews; Mark A Atkinson; Todd M Brusko
Journal:  Sci Rep       Date:  2018-03-14       Impact factor: 4.379
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