Literature DB >> 15035974

New autoimmune genes and the pathogenesis of type 1 diabetes.

Lars Hornum1, Helle Markholst.   

Abstract

Type 1 diabetes is an autoimmune disease with a complex polygenic inheritance. Until recently, only three susceptibility genes had been reproducibly identified, namely HLA, INS-VNTR, and CTLA4. During the past 7 years, a number of new putative susceptibility genes have been isolated from both human and animal models of the disease. We present eight genes implicated in type 1 diabetes etiology and discuss them in relation to the pathogenesis of the disease: VDR, IL6, IL12B, AIRE, FOXP3, B2m, Cblb, and Lyp/Ian4l1.

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Year:  2004        PMID： 15035974     DOI： 10.1007/s11892-004-0069-6

Source DB:  PubMed          Journal:  Curr Diab Rep        ISSN： 1534-4827            Impact factor:   4.810


  65 in total

1.  Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b.

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Journal:  Nature       Date:  2000-01-13       Impact factor: 49.962

2.  Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation.

Authors:  C F Terry; V Loukaci; F R Green
Journal:  J Biol Chem       Date:  2000-06-16       Impact factor: 5.157

3.  Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin.

Authors:  D V Serreze; M Bridgett; H D Chapman; E Chen; S D Richard; E H Leiter
Journal:  J Immunol       Date:  1998-02-01       Impact factor: 5.422

4.  Two genetic loci regulate T cell-dependent islet inflammation and drive autoimmune diabetes pathogenesis.

Authors:  C J Fox; A D Paterson; S M Mortin-Toth; J S Danska
Journal:  Am J Hum Genet       Date:  2000-06-09       Impact factor: 11.025

5.  Positional cloning of the APECED gene.

Authors:  K Nagamine; P Peterson; H S Scott; J Kudoh; S Minoshima; M Heino; K J Krohn; M D Lalioti; P E Mullis; S E Antonarakis; K Kawasaki; S Asakawa; F Ito; N Shimizu
Journal:  Nat Genet       Date:  1997-12       Impact factor: 38.330

6.  Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele.

Authors:  G Morahan; D Huang; S I Ymer; M R Cancilla; K Stephen; P Dabadghao; G Werther; B D Tait; L C Harrison; P G Colman
Journal:  Nat Genet       Date:  2001-02       Impact factor: 38.330

7.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.

Authors:  Jason D Fontenot; Marc A Gavin; Alexander Y Rudensky
Journal:  Nat Immunol       Date:  2003-03-03       Impact factor: 25.606

8.  Cuttine edge: diabetes-associated quantitative trait locus, Idd4, is responsible for the IL-12p40 overexpression defect in nonobese diabetic (NOD) mice.

Authors:  Pedro B Simpson; Monica S Mistry; Richard A Maki; Weidong Yang; David A Schwarz; Eric B Johnson; Francisco M Lio; David G Alleva
Journal:  J Immunol       Date:  2003-10-01       Impact factor: 5.422

9.  Genetics of the BB rat: association of autoimmune disorders (diabetes, insulitis, and thyroiditis) with lymphopenia and major histocompatibility complex class II.

Authors:  T Awata; D L Guberski; A A Like
Journal:  Endocrinology       Date:  1995-12       Impact factor: 4.736

10.  A male-female bias in type 1 diabetes and linkage to chromosome Xp in MHC HLA-DR3-positive patients.

Authors:  F Cucca; J V Goy; Y Kawaguchi; L Esposito; M E Merriman; A J Wilson; H J Cordell; S C Bain; J A Todd
Journal:  Nat Genet       Date:  1998-07       Impact factor: 38.330
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  6 in total

1.  Mycobacterium avium subsp. paratuberculosis as a trigger of type-1 diabetes: destination Sardinia, or beyond?

Authors:  Pittu Sandhya Rani; Leonardo A Sechi; Niyaz Ahmed
Journal:  Gut Pathog       Date:  2010-03-29       Impact factor: 4.181

2.  Reversal of diabetes in mice by intrahepatic injection of bone-derived GFP-murine mesenchymal stem cells infected with the recombinant retrovirus-carrying human insulin gene.

Authors:  Jian Xu; Yuhua Lu; Fei Ding; Xi Zhan; Mingyan Zhu; Zhiwei Wang
Journal:  World J Surg       Date:  2007-09       Impact factor: 3.352

3.  Foxp3 and Treg cells in HIV-1 infection and immuno-pathogenesis.

Authors:  Derek Holmes; Qi Jiang; Liguo Zhang; Lishan Su
Journal:  Immunol Res       Date:  2008       Impact factor: 2.829

4.  FoxP3 enhances HIV-1 gene expression by modulating NFkappaB occupancy at the long terminal repeat in human T cells.

Authors:  Derek Holmes; Geoffry Knudsen; Stephanie Mackey-Cushman; Lishan Su
Journal:  J Biol Chem       Date:  2007-04-06       Impact factor: 5.157

5.  Delayed functional maturation of natural regulatory T cells in the medulla of postnatal thymus: role of TSLP.

Authors:  Qi Jiang; Hua Su; Geoffry Knudsen; Whitney Helms; Lishan Su
Journal:  BMC Immunol       Date:  2006-04-03       Impact factor: 3.615

6.  An important step towards a prevascularized islet microencapsulation device: in vivo prevascularization by combination of mesenchymal stem cells on micropatterned membranes.

Authors:  Milou Groot Nibbelink; Katarzyna Skrzypek; Lisanne Karbaat; Sanne Both; Jacqueline Plass; Bettie Klomphaar; Jéré van Lente; Sieger Henke; Marcel Karperien; Dimitrios Stamatialis; Aart van Apeldoorn
Journal:  J Mater Sci Mater Med       Date:  2018-11-09       Impact factor: 3.896
  6 in total

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